pI: 5.1263 |
Length (AA): 745 |
MW (Da): 82324 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 743 | 5kvu (A) | 5 | 743 | 89.00 | 0 | 1 | 2.11675 | -1.45 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126691)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G35830 | aconitate hydratase 1 |
Arabidopsis thaliana | AT2G05710 | aconitate hydratase 3 |
Arabidopsis thaliana | AT4G26970 | aconitase 2 |
Babesia bovis | BBOV_III011790 | aconitate hydratase 1 family protein |
Brugia malayi | Bm1_07420 | aconitate hydratase, mitochondrial |
Candida albicans | CaO19.13953 | likely mitochondrial aconitase family protein similar to S. cerevisiae YJL200C |
Candida albicans | CaO19.6632 | likely mitochondrial aconitase family protein similar to S. cerevisiae YJL200C |
Candida albicans | CaO19.6385 | similar to S. cerevisiae ACO1 (YLR304C) mitochondrial aconitate hydratase |
Candida albicans | CaO19.13742 | similar to S. cerevisiae ACO1 (YLR304C) mitochondrial aconitate hydratase |
Caenorhabditis elegans | CELE_ZK455.1 | Protein ACO-1 |
Caenorhabditis elegans | CELE_F54H12.1 | Protein ACO-2, isoform C |
Dictyostelium discoideum | DDB_G0278779 | aconitase, mitochondrial |
Dictyostelium discoideum | DDB_G0279159 | aconitate hydratase |
Drosophila melanogaster | Dmel_CG4900 | Iron regulatory protein 1A |
Drosophila melanogaster | Dmel_CG4706 | CG4706 gene product from transcript CG4706-RA |
Drosophila melanogaster | Dmel_CG6342 | Iron regulatory protein 1B |
Drosophila melanogaster | Dmel_CG9244 | Aconitase |
Escherichia coli | b0771 | putative hydratase |
Escherichia coli | b1276 | aconitate hydratase 1 |
Echinococcus granulosus | EgrG_000158240 | aconitate hydratase mitochondrial |
Echinococcus multilocularis | EmuJ_000158800 | aconitate hydratase, mitochondrial |
Homo sapiens | ENSG00000100412 | aconitase 2, mitochondrial |
Homo sapiens | ENSG00000122729 | aconitase 1, soluble |
Homo sapiens | ENSG00000136381 | iron-responsive element binding protein 2 |
Leishmania braziliensis | LbrM.18.0570 | aconitase, putative |
Leishmania donovani | LdBPK_180510.1 | aconitase, putative |
Leishmania infantum | LinJ.18.0510 | aconitase, putative |
Leishmania major | LmjF.18.0510 | aconitase, putative |
Leishmania mexicana | LmxM.18.0510 | aconitase, putative |
Mycobacterium leprae | ML2672c | PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD2 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) |
Mycobacterium leprae | ML1814 | PROBABLE IRON-REGULATED ACONITATE HYDRATASE ACN (Citrate hydro-lyase) (Aconitase) |
Mus musculus | ENSMUSG00000028405 | aconitase 1 |
Mus musculus | ENSMUSG00000022477 | aconitase 2, mitochondrial |
Mus musculus | ENSMUSG00000032293 | iron responsive element binding protein 2 |
Mycobacterium tuberculosis | Rv0066c | Probable isocitrate dehydrogenase [NADP] Icd2 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) |
Mycobacterium tuberculosis | Rv1475c | Probable iron-regulated aconitate hydratase Acn (citrate hydro-lyase) (aconitase) |
Mycobacterium ulcerans | MUL_1484 | aconitate hydratase |
Mycobacterium ulcerans | MUL_4939 | isocitrate dehydrogenase [NADP] Icd2 |
Neospora caninum | NCLIV_046260 | Iron regulatory protein-like protein, related |
Oryza sativa | 4331547 | Os03g0136900 |
Oryza sativa | 4340833 | Os06g0303400 |
Oryza sativa | 9266421 | Os09g0449600 |
Plasmodium berghei | PBANKA_1355200 | aconitate hydratase, putative |
Plasmodium falciparum | PF3D7_1342100 | aconitate hydratase |
Plasmodium knowlesi | PKNH_1259300 | aconitate hydratase, putative |
Plasmodium vivax | PVX_083005 | aconitate hydratase I, putative |
Plasmodium yoelii | PY00319 | aconitate hydratase 1 |
Saccharomyces cerevisiae | YLR304C | aconitate hydratase ACO1 |
Saccharomyces cerevisiae | YJL200C | aconitate hydratase ACO2 |
Schistosoma japonicum | Sjp_0067360 | ko:K01680 aconitate hydratase [EC4.2.1.3], putative |
Schistosoma mansoni | Smp_063090 | aconitate hydratase |
Schmidtea mediterranea | mk4.000109.03 | Aconitate hydratase, mitochondrial |
Schmidtea mediterranea | mk4.089615.01 | Probable aconitate hydratase, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.10.17200 | aconitase, putative |
Trypanosoma brucei | Tb927.10.14000 | aconitase |
Trypanosoma congolense | TcIL3000_10_11690 | aconitase |
Trypanosoma cruzi | TcCLB.511277.290 | aconitase, putative |
Toxoplasma gondii | TGME49_226730 | aconitate hydratase ACN/IRP |
Theileria parva | TP01_1050 | aconitate hydratase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0540 | aconitate hydratase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu66 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.10.14000 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14000 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14000 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.14000 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0771 | Escherichia coli | non-essential | goodall |
b1276 | Escherichia coli | non-essential | goodall |
CELE_F54H12.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F54H12.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F54H12.1 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1355200 | Plasmodium berghei | Essential | plasmo |
TGME49_226730 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.