pI: 5.15 |
Length (AA): 1806 |
MW (Da): 191593 |
Paralog Number:
12
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 14 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 903 | 4mz0 (A) | 7 | 935 | 38.00 | 0 | 1 | 0.938785 | -0.2 |
36 | 1441 | 2vz8 (B) | 2 | 1459 | 21.00 | 0 | 1 | 0.899516 | 1 |
37 | 892 | 5bp1 (A) | 8 | 880 | 50.00 | 0 | 1 | 0.971176 | -0.27 |
450 | 871 | 3tzy (A) | 600 | 1031 | 32.00 | 0 | 1 | 0.609866 | -0.68 |
561 | 868 | 4rl1 (A) | 27 | 349 | 36.00 | 0 | 1 | 0.598743 | -0.81 |
1157 | 1605 | 5d2e (A) | 9 | 452 | 20.00 | 0.000000018 | 1 | 0.466616 | 0.13 |
1203 | 1673 | 3mje (A) | 13 | 472 | 29.00 | 0 | 1 | 0.530997 | -0.23 |
1426 | 1550 | 2ehd (A) | 4 | 122 | 24.00 | 0.013 | 1 | 0.386214 | -0.56 |
1429 | 1515 | 2hq1 (A) | 7 | 107 | 28.00 | 0.084 | 0.98 | 0.490173 | -1.03 |
1431 | 1502 | 3tl3 (A) | 9 | 68 | 47.00 | 0.54 | 0.99 | 0.389067 | 0 |
1683 | 1770 | 2ju1 (A) | 7 | 94 | 33.00 | 0 | 1 | 0.494926 | -0.8 |
1697 | 1771 | 4hkg (A) | 7 | 81 | 17.00 | 0.000056 | 0.32 | 0.336528 | -1.22 |
1705 | 1770 | 2cg5 (B) | 2131 | 2190 | 35.00 | 0.09 | 1 | 0.443745 | -0.77 |
1718 | 1769 | 5msr (D) | 690 | 742 | 31.00 | 0.28 | 0.84 | 0.486793 | -1.03 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126633)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_08575 | Beta-ketoacyl synthase, N-terminal domain containing protein |
Brugia malayi | Bm1_35180 | oxidoreductase, zinc-binding dehydrogenase family protein |
Caenorhabditis elegans | CELE_F32H2.5 | Protein FASN-1 |
Cryptosporidium hominis | Chro.30258 | hypothetical protein |
Cryptosporidium hominis | Chro.40330 | hypothetical protein |
Cryptosporidium parvum | cgd4_2900 | polyketide synthase |
Cryptosporidium parvum | cgd3_2180 | type I fatty acid synthase |
Dictyostelium discoideum | DDB_G0281475 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0284001 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0271000 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0271614 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0291684 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0290703 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0271530 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0288457 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0275077 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0291614 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0271618 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0271524 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0290709 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0293912 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0290729 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0295667 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0272981 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0275069 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0283931 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0290943 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0271662 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0290853 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0290701 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0290469 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0269364 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0270572 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0287095 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0291604 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0273007 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0290937 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0282029 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0272859 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0282027 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0287119 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0292544 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0295659 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0293902 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0290467 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0290699 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0271520 | beta-ketoacyl synthase family protein |
Dictyostelium discoideum | DDB_G0290737 | beta-ketoacyl synthase family protein |
Drosophila melanogaster | Dmel_CG3523 | CG3523 gene product from transcript CG3523-RA |
Drosophila melanogaster | Dmel_CG17374 | CG17374 gene product from transcript CG17374-RC |
Drosophila melanogaster | Dmel_CG3524 | CG3524 gene product from transcript CG3524-RB |
Homo sapiens | ENSG00000169710 | fatty acid synthase |
Loa Loa (eye worm) | LOAG_12875 | acyl carrier protein |
Loa Loa (eye worm) | LOAG_12856 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05412 | fatty acid synthase |
Loa Loa (eye worm) | LOAG_06344 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05695 | hypothetical protein |
Mycobacterium leprae | ML2353c | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE |
Mycobacterium leprae | ML2356c | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB |
Mycobacterium leprae | ML1229 | PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 |
Mycobacterium leprae | ML2357c | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA |
Mycobacterium leprae | ML2354c | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD |
Mycobacterium leprae | ML0101 | Polyketide synthase Pks13 |
Mycobacterium leprae | ML0139 | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas |
Mycobacterium leprae | ML2355c | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC |
Mycobacterium leprae | ML0135 | Probable polyketide synthase Pks1 |
Mus musculus | ENSMUSG00000025153 | fatty acid synthase |
Mycobacterium tuberculosis | Rv2931 | Phenolpthiocerol synthesis type-I polyketide synthase PpsA |
Mycobacterium tuberculosis | Rv2933 | Phenolpthiocerol synthesis type-I polyketide synthase PpsC |
Mycobacterium tuberculosis | Rv2934 | Phenolpthiocerol synthesis type-I polyketide synthase PpsD |
Mycobacterium tuberculosis | Rv2940c | Probable multifunctional mycocerosic acid synthase membrane-associated Mas |
Mycobacterium tuberculosis | Rv1527c | Probable polyketide synthase Pks5 |
Mycobacterium tuberculosis | Rv1180 | Probable polyketide beta-ketoacyl synthase Pks3 |
Mycobacterium tuberculosis | Rv1181 | Probable polyketide beta-ketoacyl synthase Pks4 |
Mycobacterium tuberculosis | Rv2048c | Polyketide synthase Pks12 |
Mycobacterium tuberculosis | Rv3800c | Polyketide synthase Pks13 |
Mycobacterium tuberculosis | Rv0405 | Probable membrane bound polyketide synthase Pks6 |
Mycobacterium tuberculosis | Rv1661 | Probable polyketide synthase Pks7 |
Mycobacterium tuberculosis | Rv1662 | Probable polyketide synthase Pks8 |
Mycobacterium tuberculosis | Rv2935 | Phenolpthiocerol synthesis type-I polyketide synthase PpsE |
Mycobacterium tuberculosis | Rv2932 | Phenolpthiocerol synthesis type-I polyketide synthase PpsB |
Mycobacterium tuberculosis | Rv1664 | Probable polyketide synthase Pks9 |
Mycobacterium tuberculosis | Rv2947c | Probable polyketide synthase Pks15 |
Mycobacterium tuberculosis | Rv2946c | Probable polyketide synthase Pks1 |
Mycobacterium tuberculosis | Rv3825c | Polyketide synthase Pks2 |
Mycobacterium ulcerans | MUP039c | Type I modular polyketide synthase |
Mycobacterium ulcerans | MUL_2018 | phenolpthiocerol synthesis type-I polyketide synthase PpsB |
Mycobacterium ulcerans | MUP040c | Type I modular polyketide synthase |
Mycobacterium ulcerans | MUL_2005 | polyketide synthase |
Mycobacterium ulcerans | MUL_1655 | polyketide synthase Pks9 |
Mycobacterium ulcerans | MUL_2016 | phenolpthiocerol synthesis type-I polyketide synthase PpsD |
Mycobacterium ulcerans | MUL_2010 | multifunctional mycocerosic acid synthase membrane-associated Mas |
Mycobacterium ulcerans | MUL_2015 | phenolpthiocerol synthesis type-I polyketide synthase PpsE |
Mycobacterium ulcerans | MUP032c | Type I modular polyketide synthase |
Mycobacterium ulcerans | MUL_2266 | polyketide synthase |
Mycobacterium ulcerans | MUL_2019 | phenolpthiocerol synthesis type-I polyketide synthase PpsA |
Mycobacterium ulcerans | MUL_4983 | polyketide synthase Pks13 |
Mycobacterium ulcerans | MUL_2017 | phenolpthiocerol synthesis type-I polyketide synthase PpsC |
Neospora caninum | NCLIV_001690 | Short-chain dehydrogenase/reductase SDR, related |
Neospora caninum | NCLIV_020690 | Soraphen polyketide synthase A, related |
Neospora caninum | NCLIV_050890 | KR domain domain-containing protein, putative |
Onchocerca volvulus | OVOC1839 |
|
Onchocerca volvulus | OVOC5784 | Fatty acid synthase homolog |
Schmidtea mediterranea | mk4.052433.01 | |
Toxoplasma gondii | TGME49_294820 | type I fatty acid synthase, putative |
Toxoplasma gondii | TGME49_204560 | type I fatty acid synthase, putative |
Toxoplasma gondii | TGME49_326200 | type I fatty acid synthase |
Toxoplasma gondii | TGME49_236990 | beta-ketoacyl synthase, N-terminal domain-containing protein |
Toxoplasma gondii | TGME49_236980 | AMP-binding enzyme domain-containing protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2988 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu3867 | Mycobacterium tuberculosis | essential | nmpdr |
mtu408 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1690 | Mycobacterium tuberculosis | essential | nmpdr |
mtu1691 | Mycobacterium tuberculosis | essential | nmpdr |
mtu2981 | Mycobacterium tuberculosis | non-essential | nmpdr |
CELE_F32H2.5 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_F32H2.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F32H2.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F32H2.5 | Caenorhabditis elegans | sterile | wormbase |
TGME49_294820 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_204560 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_236990 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_236980 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_326200 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_294820 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_204560 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_236990 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_236980 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_326200 | Toxoplasma gondii | Probably non-essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | fatty acid synthase | Compounds | References |
Gallus gallus | Fatty acid synthase | Compounds | References |
Rattus norvegicus | Fatty acid synthase | Compounds | References |
Homo sapiens | fatty acid synthase | Compounds | References |