Detailed view for MUL_1627

Basic information

TDR Targets ID: 954000
Mycobacterium ulcerans, initiation factor IF-3 InfC

Source Database / ID:  KEGG  

pI: 9.7707 | Length (AA): 178 | MW (Da): 19949 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00707   Translation initiation factor IF-3, C-terminal domain
PF05198   Translation initiation factor IF-3, N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003743   translation initiation factor activity  
GO:0006413   translational initiation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
67 153 2ife (A) 92 179 46.00 0.000000000021 1 1.16176 -1.3
67 152 1i96 (V) 83 168 55.00 0.00000000012 0.34 0.929146 1.31
68 150 1tig (A) 85 167 51.00 0 1 1.29929 -2.32

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129028)

Species Accession Gene Product
Arabidopsis thaliana AT4G30690   translation initiation factor IF-3
Arabidopsis thaliana AT2G24060   translation initiation factor IF-3
Chlamydia trachomatis CT_833   translation initiation factor IF-3
Dictyostelium discoideum DDB_G0288477   hypothetical protein
Escherichia coli b1718   translation initiation factor IF-3
Homo sapiens ENSG00000122033   mitochondrial translational initiation factor 3
Mycobacterium leprae ML1394   PROBABLE INITIATION FACTOR IF-3 INFC
Mus musculus ensembl-mmu:ENSMUSG00000016510   mitochondrial translational initiation factor 3
Mycobacterium tuberculosis Rv1641   Probable initiation factor if-3 InfC
Mycobacterium ulcerans MUL_1627   initiation factor IF-3 InfC
Oryza sativa 4330995   Os02g0794400
Plasmodium berghei PBANKA_0705400   translation initiation factor IF-3, putative
Plasmodium falciparum PF3D7_0825200   translation initiation factor IF-3
Plasmodium knowlesi PKNH_1319200   translation initiation factor IF-3, putative
Plasmodium vivax PVX_089095   translation initiation factor IF-3, putative
Plasmodium yoelii PY05664   hypothetical protein
Schmidtea mediterranea mk4.039025.00  
Toxoplasma gondii TGME49_224235   translation initiation factor IF-3 protein
Treponema pallidum TP0850   translation initiation factor IF-3
Wolbachia endosymbiont of Brugia malayi Wbm0473   translation initiation factor 3, IF-3

Essentiality

MUL_1627 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b1718 Escherichia coli essential goodall
TGME49_224235 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier MUL_1627 (Mycobacterium ulcerans), initiation factor IF-3 InfC
Title for this comment
Comment