pI: 9.7501 |
Length (AA): 281 |
MW (Da): 30012 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 181 | 3enn (A) | 5 | 187 | 30.00 | 0 | 1 | 1.10715 | -1.07 |
4 | 244 | 3m1a (A) | 4 | 251 | 38.00 | 0 | 1 | 1.36335 | -0.79 |
5 | 169 | 4dyv (A) | 28 | 200 | 36.00 | 0 | 1 | 1.07889 | -0.85 |
7 | 277 | 1gz6 (A) | 11 | 288 | 23.00 | 0 | 1 | 1.13291 | 0.39 |
17 | 51 | 4zqb (A) | 148 | 185 | 54.00 | 0.91 | 0.85 | 0.585255 | 0.7 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126778)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G65205 | Rossmann-fold NAD(P)-binding domain-containing protein |
Arabidopsis thaliana | AT5G10050 | Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain-containing protein |
Arabidopsis thaliana | AT5G50700 | hydroxysteroid dehydrogenase 1 |
Arabidopsis thaliana | AT5G50600 | hydroxysteroid dehydrogenase 1 |
Candida albicans | CaO19.5615 | one of three genes similar to S. cerevisiae AYR1 (YIL124W) 1-Acyl dihydroxyacetone phosphate reductase involved in phosphatidic |
Candida albicans | CaO19.5879 | one of three genes similar to S. cerevisiae AYR1 (YIL124W) 1-Acyl dihydroxyacetone phosphate reductase involved in phosphatidic |
Candida albicans | CaO19.13300 | one of three genes similar to S. cerevisiae AYR1 (YIL124W) 1-Acyl dihydroxyacetone phosphate reductase involved in phosphatidic |
Candida albicans | CaO19.6167 | one of three genes similar to S. cerevisiae AYR1 (YIL124W) 1-Acyl dihydroxyacetone phosphate reductase involved in phosphatidic |
Caenorhabditis elegans | CELE_F28H7.2 | Protein F28H7.2 |
Dictyostelium discoideum | DDB_G0294589 | short-chain dehydrogenase/reductase family protein |
Dictyostelium discoideum | DDB_G0278655 | glucose/ribitol dehydrogenase family protein |
Dictyostelium discoideum | DDB_G0284209 | short-chain dehydrogenase/reductase family protein |
Dictyostelium discoideum | DDB_G0289127 | glucose/ribitol dehydrogenase family protein |
Dictyostelium discoideum | DDB_G0281673 | short-chain dehydrogenase/reductase family protein |
Dictyostelium discoideum | DDB_G0284277 | hypothetical protein |
Dictyostelium discoideum | DDB_G0295807 | glucose/ribitol dehydrogenase family protein |
Dictyostelium discoideum | DDB_G0284429 | glucose/ribitol dehydrogenase family protein |
Dictyostelium discoideum | DDB_G0289129 | glucose/ribitol dehydrogenase family protein |
Dictyostelium discoideum | DDB_G0283935 | hypothetical protein |
Dictyostelium discoideum | DDB_G0286861 | hypothetical protein |
Dictyostelium discoideum | DDB_G0289259 | hypothetical protein |
Dictyostelium discoideum | DDB_G0291674 | hypothetical protein |
Dictyostelium discoideum | DDB_G0285753 | hypothetical protein |
Dictyostelium discoideum | DDB_G0271802 | hypothetical protein |
Dictyostelium discoideum | DDB_G0279545 | hypothetical protein |
Dictyostelium discoideum | DDB_G0275559 | glucose/ribitol dehydrogenase family protein |
Dictyostelium discoideum | DDB_G0269340 | short-chain dehydrogenase/reductase family protein |
Dictyostelium discoideum | DDB_G0292574 | glucose/ribitol dehydrogenase family protein |
Dictyostelium discoideum | DDB_G0289167 | hypothetical protein |
Dictyostelium discoideum | DDB_G0288591 | short-chain dehydrogenase/reductase family protein |
Dictyostelium discoideum | DDB_G0286845 | glucose/ribitol dehydrogenase family protein |
Dictyostelium discoideum | DDB_G0271748 | hypothetical protein |
Dictyostelium discoideum | DDB_G0279783 | hypothetical protein |
Dictyostelium discoideum | DDB_G0284207 | short-chain dehydrogenase/reductase family protein |
Dictyostelium discoideum | DDB_G0272466 | glucose/ribitol dehydrogenase family protein |
Dictyostelium discoideum | DDB_G0290659 | short-chain dehydrogenase/reductase family protein |
Dictyostelium discoideum | DDB_G0291676 | hypothetical protein |
Dictyostelium discoideum | DDB_G0290329 | glucose/ribitol dehydrogenase family protein |
Dictyostelium discoideum | DDB_G0286849 | hypothetical protein |
Escherichia coli | b0493 | putative oxidoreductase |
Homo sapiens | ENSG00000080511 | retinol dehydrogenase 8 (all-trans) |
Mus musculus | ENSMUSG00000053773 | retinol dehydrogenase 8 |
Mycobacterium tuberculosis | Rv1882c | Probable short-chain type dehydrogenase/reductase |
Mycobacterium tuberculosis | Rv3530c | Possible oxidoreductase |
Mycobacterium ulcerans | MUL_2977 | short chain dehydrogenase |
Mycobacterium ulcerans | MUL_4092 | short chain dehydrogenase |
Mycobacterium ulcerans | MUL_3423 | short chain dehydrogenase |
Mycobacterium ulcerans | MUL_2794 | short chain dehydrogenase |
Oryza sativa | 4335679 | Os04g0390800 |
Oryza sativa | 4336030 | Os04g0457200 |
Saccharomyces cerevisiae | YIL124W | acylglycerone-phosphate reductase |
Schmidtea mediterranea | mk4.052776.00 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Mycobacterium tuberculosis | non-essential | nmpdr | |
mtu3591 | Mycobacterium tuberculosis | non-essential | nmpdr |
b0493 | Escherichia coli | non-essential | goodall |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Trypanosoma brucei | pteridine reductase 1 | 268 aa | 28.0% | 225 aa | Compounds | References |
Macaca mulatta | Hydroxysteroid 11-beta dehydrogenase 1 | 140 aa | 26.7% | 135 aa | Compounds | References |