pI: 5.2985 |
Length (AA): 406 |
MW (Da): 45334 |
Paralog Number:
16
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 406 | 1cpt (A) | 1 | 428 | 27.00 | 0 | 1 | 1.3033 | -0.69 |
6 | 402 | 2wm5 (A) | 18 | 426 | 31.00 | 0 | 1 | 1.39863 | -0.75 |
8 | 403 | 3r9b (A) | 16 | 414 | 34.00 | 0 | 1 | 1.41817 | -0.55 |
11 | 405 | 3buj (A) | 3 | 395 | 28.00 | 0 | 1 | 1.33921 | -1.02 |
87 | 374 | 5mnv (I) | 94 | 376 | 40.00 | 0 | 1 | 0.83316 | 0.69 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_132455)
Species | Accession | Gene Product |
---|---|---|
Escherichia coli | b1803 | putative YeaWX dioxygenase beta subunit, reductase component |
Mycobacterium leprae | ML2088c | putative cytochrome p450 |
Mycobacterium tuberculosis | Rv3121 | Probable cytochrome P450 141 Cyp141 |
Mycobacterium tuberculosis | Rv3545c | Probable cytochrome P450 125 Cyp125 |
Mycobacterium tuberculosis | Rv2776c | Probable oxidoreductase |
Mycobacterium tuberculosis | Rv0766c | Probable cytochrome P450 123 Cyp123 |
Mycobacterium tuberculosis | Rv0778 | Possible cytochrome P450 126 Cyp126 |
Mycobacterium tuberculosis | Rv2266 | Probable cytochrome P450 124 Cyp124 |
Mycobacterium tuberculosis | Rv2268c | Probable cytochrome P450 128 Cyp128 |
Mycobacterium tuberculosis | Rv1256c | Probable cytochrome P450 130 Cyp130 |
Mycobacterium tuberculosis | Rv3518c | Probable cytochrome P450 monooxygenase 142 Cyp142 |
Mycobacterium tuberculosis | Rv1785c | Probable cytochrome P450 143 Cyp143 |
Mycobacterium tuberculosis | Rv1880c | Probable cytochrome P450 140 Cyp140 |
Mycobacterium ulcerans | MUL_3872 | cytochrome P450 187A5 Cyp187A5 |
Mycobacterium ulcerans | MUL_1282 | cytochrome P450 124A1, Cyp124A1 |
Mycobacterium ulcerans | MUL_3106 | cytochrome P450 143A3 Cyp143A3 |
Mycobacterium ulcerans | MUL_0491 | cytochrome P450 126A3 Cyp126A3 |
Mycobacterium ulcerans | MUL_3863 | cytochrome P450 108B4 Cyp108B4 |
Mycobacterium ulcerans | MUL_0324 | cytochrome P450 189A7 Cyp189A7 |
Mycobacterium ulcerans | MUL_2159 | oxidoreductase |
Mycobacterium ulcerans | MUL_0333 | cytochrome P450 105Q4 Cyp105Q4 |
Mycobacterium ulcerans | MUL_0475 | cytochrome P450 123A3 Cyp123A3 |
Mycobacterium ulcerans | MUL_4106 | cytochrome P450 125A7 Cyp125A7 |
Mycobacterium ulcerans | MUL_4077 | cytochrome P450 142A3 Cyp142A3 |
Mycobacterium ulcerans | MUL_3091 | cytochrome P450 143A4 Cyp143A4 |
Mycobacterium ulcerans | MUL_1049 | cytochrome P450 191A3 Cyp191A3 |
Mycobacterium ulcerans | MUL_0317 | cytochrome P450 188A3 Cyp188A3 |
Mycobacterium ulcerans | MUL_2979 | cytochrome P450 140A5 Cyp140A5 |
Mycobacterium ulcerans | MUL_3860 | cytochrome P450 187A4 Cyp187A4 |
Mycobacterium ulcerans | MUP053c | cytochrome p450 150 cyp150 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2301 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2303 | Mycobacterium tuberculosis | essential | nmpdr |
mtu3579 | Mycobacterium tuberculosis | non-essential | nmpdr |
Mycobacterium tuberculosis | non-essential | nmpdr | |
b1803 | Escherichia coli | non-essential | goodall |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | Compounds | References |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | Compounds | References |
Pseudomonas putida | Cytochrome P450-cam | Compounds | References |
Amycolatopsis orientalis | Cytochrome P450 165B3 | Compounds | References |