Detailed view for MUL_2033

Basic information

TDR Targets ID: 954689
Mycobacterium ulcerans, chromosome partition protein Smc
Source Database / ID:  KEGG  

pI: 4.845 | Length (AA): 1200 | MW (Da): 130713 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02463   RecF/RecN/SMC N terminal domain
PF06470   SMC proteins Flexible Hinge Domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0007062   sister chromatid cohesion  
GO:0005694   chromosome  
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0051276   chromosome organization and biogenesis  
GO:0030261   chromosome condensation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 169 5h68 (A) 1 1031 61.00 0 1 0.889933 -0.47
389 767 4rsi (B) 565 942 16.00 0 1 0.421733 0.74
688 830 5cwj (A) 22 161 30.00 0.49 0.75 0.492267 -0.96
956 1180 3zgx (A) 155 1175 42.00 0 1 0.6389 0.14
983 1184 5xns (A) 184 1154 40.00 0 1 0.620433 0.1
1135 1189 5h68 (A) 1126 1180 42.00 0.00000036 0.62 0.428833 0.63
1136 1187 1e69 (A) 1114 1164 39.00 0.072 0.77 0.399333 0.65

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127360)

Species Accession Gene Product
Arabidopsis thaliana AT5G62410   structural maintenance of chromosome 2
Arabidopsis thaliana AT3G47460   structural maintenance of chromosomes protein 2-2
Babesia bovis BBOV_II001730   smc family/structural maintenance of chromosome
Brugia malayi Bm1_43270   SMC proteins Flexible Hinge Domain containing protein
Candida albicans CaO19.3623   potential SMC chromosomal ATPase similar to S. cerevisiae SMC2 (YFR031C) nuclear condensin complex ATPase
Candida albicans CaO19.11106   potential SMC chromosomal ATPase similar to S. cerevisiae SMC2 (YFR031C) nuclear condensin complex ATPase
Caenorhabditis elegans CELE_M106.1   Protein MIX-1
Cryptosporidium hominis Chro.40250   SMC2 protein
Cryptosporidium parvum cgd4_2200   SMC2 protein
Dictyostelium discoideum DDB_G0284499   structural maintenance of chromosome protein
Drosophila melanogaster Dmel_CG10212   CG10212 gene product from transcript CG10212-RA
Echinococcus granulosus EgrG_000602100   structural maintenance of chromosomes protein 2
Entamoeba histolytica EHI_049770   mitotic chromosome and X-chromosome-associated protein, putative
Echinococcus multilocularis EmuJ_000602100   structural maintenance of chromosomes protein 2
Giardia lamblia GL50803_23185   Hypothetical protein, similar to SMC2
Homo sapiens ENSG00000136824   structural maintenance of chromosomes 2
Leishmania braziliensis LbrM.05.0410   structural maintenance of chromosome (SMC), putative
Leishmania donovani LdBPK_050400.1   structural maintenance of chromosome (SMC), putative
Leishmania infantum LinJ.05.0400   structural maintenance of chromosome (SMC), putative
Leishmania major LmjF.05.0400   structural maintenance of chromosome (SMC), putative
Leishmania mexicana LmxM.05.0400   structural maintenance of chromosome (SMC), putative
Loa Loa (eye worm) LOAG_05577   hypothetical protein
Loa Loa (eye worm) LOAG_12292   hypothetical protein
Loa Loa (eye worm) LOAG_08510   hypothetical protein
Mus musculus ENSMUSG00000028312   structural maintenance of chromosomes 2
Mycobacterium tuberculosis Rv2922c   Probable chromosome partition protein Smc
Mycobacterium ulcerans MUL_2033   chromosome partition protein Smc
Neospora caninum NCLIV_006710   SMC2 protein, related
Oryza sativa 4325020   Os01g0904400
Plasmodium berghei PBANKA_1416900   structural maintenance of chromosomes protein 2, putative
Plasmodium falciparum PF3D7_1318400   structural maintenance of chromosomes protein 2, putative
Plasmodium knowlesi PKNH_1419200   structural maintenance of chromosomes protein 2, putative
Plasmodium vivax PVX_122740   structural maintenance of chromosome 2, putative
Plasmodium yoelii PY01780   protein mix-1, putative
Saccharomyces cerevisiae YFR031C   condensin subunit SMC2
Schistosoma japonicum Sjp_0216510   ko:K06674 structural maintenance of chromosome 2, putative
Schistosoma japonicum Sjp_0093150   ko:K06674 structural maintenance of chromosome 2, putative
Schistosoma mansoni Smp_171710   structural maintenance of chromosomes smc2
Schmidtea mediterranea mk4.003369.02   Structural maintenance of chromosomes protein 2
Schmidtea mediterranea mk4.013535.00   Mitotic chromosome and X-chromosome-associated protein mix-1
Trypanosoma brucei gambiense Tbg972.10.12590   structural maintenance of chromosome 2, putative
Trypanosoma brucei Tb11.v5.0811   structural maintenance of chromosome 2, putative
Trypanosoma brucei Tb927.10.10340   structural maintenance of chromosome 2, putative
Trypanosoma congolense TcIL3000_10_8800   structural maintenance of chromosome 2, putative
Trypanosoma cruzi TcCLB.511633.60   structural maintenance of chromosome (SMC), putative
Toxoplasma gondii TGME49_297800   RecF/RecN/SMC N terminal domain-containing protein
Theileria parva TP04_0409   condensin subunit, putative
Trichomonas vaginalis TVAG_313860   condensin subunit Smc2

Essentiality

MUL_2033 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.10340 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.10340 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.10340 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.10340 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_M106.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_M106.1 Caenorhabditis elegans larval lethal wormbase
YFR031C Saccharomyces cerevisiae inviable yeastgenome
TGME49_297800 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier MUL_2033 (Mycobacterium ulcerans), chromosome partition protein Smc
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