Detailed view for MUL_3402

Basic information

TDR Targets ID: 954738
Mycobacterium ulcerans, cytochrome P450 136A2 Cyp136A2

Source Database / ID:  KEGG  

pI: 7.2245 | Length (AA): 492 | MW (Da): 55991 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00067   Cytochrome P450

Gene Ontology

Mouse over links to read term descriptions.
GO:0016705   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  
GO:0004497   monooxygenase activity  
GO:0020037   heme binding  
GO:0005506   iron ion binding  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
35 492 6c93 (A) 24 500 26.00 0 1 1.24749 -0.56
52 492 2ve3 (A) 9 443 26.00 0 1 1.29594 -0.69
306 344 3nja (A) 40 80 49.00 0.035 0.18 0.580968 -0.54
339 460 3dsk (A) 361 492 28.00 0.71 0.07 0.384667 0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_158762)

Species Accession Gene Product
Mycobacterium tuberculosis Rv3059   Probable cytochrome P450 136 Cyp136
Mycobacterium ulcerans MUL_3402   cytochrome P450 136A2 Cyp136A2
Oryza sativa 4343395   Os07g0518500
Oryza sativa 4343396   Os07g0519300
Oryza sativa 4343391   Os07g0517900
Oryza sativa 4343397   Os07g0519500
Oryza sativa 9268990   Os07g0519100
Oryza sativa 9269865   Os07g0520100

Essentiality

MUL_3402 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3112 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 451 aa 28.6% 430 aa Compounds References
Leishmania major lanosterol 14-alpha-demethylase, putative 479 aa 21.6% 450 aa Compounds References
Trypanosoma cruzi Lanosterol 14-alpha demethylase 481 aa 24.0% 437 aa Compounds References
Oryctolagus cuniculus Cytochrome P450 2B4 491 aa 23.1% 437 aa Compounds References
Rattus norvegicus Cytochrome P450 2B1 491 aa 23.2% 409 aa Compounds References
Trypanosoma cruzi Lanosterol 14-alpha demethylase 481 aa 24.0% 437 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0012 0.5 0.5
0.0023 0.9674 0.5
0.0044 0.6112 0
0.0316 0.2652 0.5702
0.0004 0.5 0.5
0.0046 0.6591 1
0.0173 0.3457 0
0.0004 0.5 0.5
0.0032 1 0.5
0.0217 0.8044 0.5
0.0028 0.5 0.5
0.0004 0.5 0.5
0.0094 0.2887 0
0.0019 0.5 0.5
0.0055 0.5 0.5
0.0012 0.5 0.5
0.0054 1 0.5
0.0012 0.5 0.5
0.0133 0.2787 0.589
0.0108 0.2733 0.265
0.0091 0.2951 0.4172
0.0094 0.5 0.5
0.0262 0.3083 0.7032
0.0045 0.5 0.5
0.0004 0.5 0.5
0.0047 0.6638 0
0.0042 0.5 0.5
0.0004 0.5 0.5
0.0102 0.3061 0.3475
0.0073 1 1
0.00505219 0.5 0.5
0.00213675 0.269186 0
0.0065 1 0.5
0.0023 0.5 0.5
0.007 1 0.5
0.0029 0.5 0.5
0.0036 1 0.5
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0083 1 0.5
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0033 0.2605 0.5
0.0082 0.5 0.5
0.0038 0.5102 0.5
0.0004 0.5 0.5
0.0002 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0569 0.2624 0.6218
0.0003 0.5 0.5
0.0022 0.3789 0.5
0.0286 1 1
0.007 1 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0104 0.5 0.5
0.0184 0.3508 0
0.0018 0.3602 0.5
0.0015 0.5 0.5
0.0018 0.5004 0
0.0056 0.6399 1
0.0037 0.4283 0
0.004 1 0.5
0.00213675 0.269186 0
0.026 0.251 0
0.0075 0.3265 0
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0022 0.3489 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0051 0.5 0.5
0.0059 0.6064 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.008 0.2582 0
0.0037 0.2694 0.9488
0.0079 0.2909 0.5303
0.0025 0.5 0.5
0.0012 0.5 0.5
0.0082 0.5 0.5
0.0018 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0056 0.3577 1
0.0072 1 1
0.0018 0.2876 0
0.0004 0.5 0.5
0.0004 1 0.5
0.0246 0.2667 0
0.0004 0.5 0.5
0.0071 0.9628 0.5
0.0162 0.2769 0.9549
0.0084 1 0.5
0.0193 0.311 0
0.033 0.3723 0.8734
0.0048 0.6634 0
0.0184 0.3352 0.5617
0.0004 0.5 0.5
0.0023 1 1
0.0103 1 0.5
0.0075 0.2816 0
0.0093 0.5 0.5
0.0038 1 0.5
0.0004 0.5 0.5
0.0073 0.5 0.5
0.0004 0.5 0.5
0.0443 0.3118 0.6583
0.0008 0.3317 0.5
0.00213675 0.269186 0
0.0011 1 0.5
0.0004 0.5 0.5
0.0059 0.6064 0.5
0.0047 0.6638 0
0.0004 0.5 0.5
0.0004 0.5 0.5
0.00184047 0.269186 0
0.0114 1 0.5
0.0004 0.5 0.5
0.004 1 1
0.0007 0.5 0.5
0.00109509 1 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.005 0.5 0.5
0.0004 0.5 0.5
0.0007 1 0.5
0.0018 1 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0077 0.5 0.5
0.0004 0.5 0.5
0.0067 0.5 0.5
0.0015 0.5 0.5
0.0004 0.5 0.5
0.0044 0.2627 0
0.0012 0.5 0.5
0.0004 0.5 0.5
0.004 1 0.5
0.0069 0.5 0.5
0.004 0.5565 0
0.0018 0.5 0.5
0.0268 0.2982 0.6793
0.0018 0.2637 0.5
0.0016 1 0.5
0.0034 0.337 1
0.0066 1 1
0.0388 0.2772 0
0.0026 0.5 0.5
0.0119 0.5 0.5
0.0176 0.3425 0.419
0.0004 0.5 0.5
0.0008 0.5 0.5
0.006 0.2795 0
0.0004 0.5 0.5
0.0018 0.5004 0
0.0057 0.2766 1
0.0065 1 0.5
0.0235 0.3192 0.5508
0.0011 0.5 0.5
0.008 1 0.5
0.0235 0.2812 0.5751
0.0052 0.3769 0.5
0.033 0.3723 0.8734
0.0007 0.5 0.5
0.0353 0.4928 1
0.0004 0.5 0.5
0.0033 0.3348 0
0.0346 0.2559 0.5782
0.0029 0.36 0.5
0.0019 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0058 0.5 0.5
0.0004 0.5 0.5
0.0051 0.3758 0.5
0.0361 0.2704 0
0.0036 0.5 0.5
0.0055 0.2887 0
0.0103 0.6953 0.898
0.0166 0.2888 0
0.0084 0.3462 0.8853
0.0103 0.4147 0.4168
0.0032 1 0.5
0.0016 1 0.5
0.0004 0.5 0.5
0.0106 0.2751 0.2411
0.0032 0.5 0.5
0.0004 0.5 0.5
0.0042 0.3378 0
0.0004 0.5 0.5
0.0033 0.5 0.5
0.036 0.2841 0.5853
0.0011 0.5 0.5
0.0033 0.5 0.5
0.0118 0.3485 0
0.0007 0.5 0.5
0.007 0.5713 0.5
0.0059 0.6064 0.5
0.0331 0.3985 0.9186
0.0216 0.2583 0
0.0004 0.5 0.5
0.0127 0.5337 0
0.0011 0.5 0.5
0.0164 0.3784 0
0.004 1 0.5
0.0014 0.5 0.5
0.0015 0.5 0.5
0.0036 0.5 0.5
0.0012 1 0.5
0.0071 0.2928 0
0.0019 0.5 0.5
0.0046 0.2608 0
0.0004 0.5 0.5
0.0078 1 0.5
0.0012 0.5 0.5
0.0045 0.5 0.5
0.0146 0.6654 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0071 0.5 0.5
0.0185 0.2528 0
0.007 0.5 0.5
0.0011 1 0.5
0.00213675 0.269186 0
0.0011 0.5 0.5
0.0074 1 1
0.0156 0.4244 0.4152
0.003 0.3514 0.5
0.0336 0.2847 0
0.0012 0.5 0.5
0.0072 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.002 1 0.5
0.0004 0.5 0.5
0.015 0.3435 0
0.0067 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0035 0.4422 0.5
0.0323 0.2823 0.5041
0.0042 1 0.5
0.01 0.5 0.5
0.0004 0.5 0.5
0.004 1 0.5
0.0052 0.2829 0
0.0093 0.3481 0.6865
0.0051 0.5 0.5
0.008 0.5 0.5
0.0119 0.4458 0
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0012 0.5 0.5
0.000376403 0.5 0.5
0.0004 0.5 0.5
0.0036 0.4353 0
0.0027 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0032 0.5 0.5
0.0368 0.2796 0.2661
0.0075 1 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0019 0.5 0.5
0.0082 0.5 0.5
0.0011 1 0.5
0.0004 0.5 0.5
0.0016 0.5 0.5
0.0004 0.5 0.5
0.0023 0.5 0.5
0.0038 0.525 0
0.0008 0.5 0.5
0.0173 0.3858 0
0.0008 0.5 0.5
0.0028 0.2972 0.6218
0.0023 1 0.5
0.0323 0.3673 0.8441
0.0063 0.2543 0.9114
0.0284 0.2924 0.5785
0.0081 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0045 0.5 0.5
0.0008 0.3317 0.5
0.000218985 0.5 0.5
0.0054 0.5 0.5
0.0121 1 1
0.0022 0.5 0.5
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0019 0.271 0
0.0083 0.5 0.5
0.0326 0.2819 0
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0026 0.5 0.5
0.0004 0.5 0.5
0.0026 0.5 0.5
0.008 0.2556 0.8568
0.0004 0.5 0.5
0.025 0.2789 0.2789
0.0004 0.5 0.5
0.0046 0.6591 1
0.0062 0.5 0.5
0.0099 0.7062 0.5
0.0015 0.5 0.5
0.0203 0.2689 0
0.0197 0.6846 0.5
0.0157 0.3541 0
0.0081 0.5 0.5
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 1 0.5
0.0092 0.467 0
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0063 0.3886 0
0.0068 0.5 0.5
0.0083 0.6735 0.5
0.0051 0.4977 0.5
0.0004 0.5 0.5
0.000376403 0.5 0.5
0.0062 0.2905 0.2906
0.0078 0.3003 0.872
0.00777519 0.280873 0.259976
0.0189 0.5524 0
0.0004 0.5 0.5
0.0025 0.5 0.5
0.0011 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0007 0.5 0.5
0.0032 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.005 0.2698 0
0.0049 0.293 0
0.0003 0.5 0.5
0.0284 0.2726 0.2726
0.0146 0.6069 0.5
0.0114 1 0.5
0.00139338 1 0.5
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0202 0.2702 0.5108
0.0004 0.5 0.5
0.003 0.3271 0
0.0007 0.5 0.5
0.0341 0.2689 0
0.0388 0.2772 0
0.0049 0.6682 0
0.0217 0.2742 0
0.0008 0.5 0.5
0.0063 0.4653 0.5
0.0084 0.5 0.5
0.0004 0.5 0.5
0.034 0.2765 0
0.015 0.2827 0.5332
0.0004 0.5 0.5
0.015 0.2827 0.5332
0.0004 0.5 0.5
0.0029 1 0.5
0.0004 0.5 0.5
0.0022 0.5 0.5
0.0069 1 0.5
0.0057 0.2766 1
0.0145 0.7126 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0228 0.2829 0
0.0167 0.2978 0
0.0021 0.5 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0044 0.4237 0
0.005 0.3622 0.5
0.0028 0.5 0.5
0.0086 0.5 0.5
0.0073 1 1
0.0004 0.5 0.5
0.0124 0.2696 0.5779
0.0092 1 0.5
0.0067 0.5 0.5
0.0004 0.5 0.5
0.0071 0.3514 0.5
0.0004 0.5 0.5
0.0111 0.3549 0.3549
0.0008 1 0.5
0.0033 0.5 0.5
0.0069 0.2847 0.4473
0.0052 0.3825 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0003 0.5 0.5
0.0063 0.5 0.5
0.0018 0.5 0.5
0.0027 1 0.5
0.0015 0.5 0.5
0.0004 0.5 0.5
0.0059 0.6064 0.5
0.0021 0.4036 0
0.0071 0.5 0.5
0.0004 0.5 0.5
0.0007 1 0.5
0.0048 1 0.5
0.000218985 0.5 0.5
0.0068 1 1
0.0004 0.5 0.5
0.0046 0.5 0.5
0.0047 0.5 0.5
0.0008 0.5 0.5
0.0066 0.5 0.5
0.0368 0.2796 0.2661
0.0048 0.6597 0
0.005 1 0.5
0.0004 0.5 0.5
0.002 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0063 0.5 0.5
0.0087 1 0.5
0.0019 0.2756 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0099 0.7122 0.5
0.0015 0.5 0.5
0.0065 0.3393 0
0.0004 1 0.5
0.0027 0.5 0.5
0.0004 0.5 0.5
0.0133 0.256 0.3222
0.0004 0.5 0.5
0.0038 0.5 0.5
0.0249 0.3082 0.6587
0.0004 0.5 0.5
0.0076 1 1
0.026 0.251 0
0.000396385 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0166 0.5366 0
0.0331 0.3985 0.9186
0.0053 1 1
0.0289 0.2916 0.6112
0.0047 0.6689 0
0.0004 0.5 0.5
0.0087 1 0.5
0.0004 0.5 0.5
0.0059 0.5 0.5
0.0267 0.27 0
0.0137 0.271 0.5279
0.0065 0.5 0.5
0.0067 0.5 0.5
0.0569 0.2624 0.6218
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0122 0.4249 0.4072
0.0284 0.2924 0.5785
0.0004 0.5 0.5
0.0004 0.5 0.5
0.033 0.3723 0.8734
0.0353 0.4928 1
0.0119 0.4458 0
0.0316 0.2652 0.5702
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0174 0.2937 0
0.0068 0.4312 1
0.0059 0.5 0.5
0.0046 0.5 0.5
0.00451124 0.405669 0
0.0004 0.5 0.5
0.0004 0.5 0.5
0.007 0.3303 0.3832
0.0324 0.2701 0.2701
0.0291 0.2657 0
0.0019 0.271 0
0.0008 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_3402 (Mycobacterium ulcerans), cytochrome P450 136A2 Cyp136A2
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