Detailed view for MUL_3960

Basic information

TDR Targets ID: 954864
Mycobacterium ulcerans, F0F1 ATP synthase subunit A
Source Database / ID:  KEGG  

pI: 6.4888 | Length (AA): 250 | MW (Da): 27374 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00119   ATP synthase A chain

Gene Ontology

Mouse over links to read term descriptions.
GO:0045263   proton-transporting ATP synthase complex, coupling factor F(o)  
GO:0015078   hydrogen ion transmembrane transporter activity  
GO:0015986   ATP synthesis coupled proton transport  

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
84 240 1c17 (M) 98 265 37.00 0 0.24 0.6655 1.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128903)

Species Accession Gene Product
Arabidopsis thaliana ArthMp035   ATPase subunit 6
Arabidopsis thaliana AT2G07741   ATPase, F0 complex, subunit A protein
Arabidopsis thaliana ArthMp098   ATPase subunit 6
Arabidopsis thaliana ArthCp010   ATPase IV subunit
Candida albicans CaalfMp06   ATPase subunit 6
Dictyostelium discoideum DidioMp19   ATPase subunit 6
Escherichia coli b3738   F0 sector of membrane-bound ATP synthase, subunit a
Homo sapiens 4508   ATP synthase F0 subunit 6
Mycobacterium leprae ML1139   PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6)
Mus musculus 17705   ATP synthase F0 subunit 6
Mycobacterium tuberculosis Rv1304   Probable ATP synthase a chain AtpB (protein 6)
Mycobacterium ulcerans MUL_3960   F0F1 ATP synthase subunit A
Oryza sativa 9271958   Os10g0355100
Oryza sativa 6450195   ATP synthase F0 subunit 6
Oryza sativa 4349180   Os10g0527100
Oryza sativa 3131393   ATPase IV subunit
Saccharomyces cerevisiae Q0085   F1F0 ATP synthase subunit A
Schistosoma japonicum Sjp_0080510   IPR000568,ATPase, F0 complex, subunit A,domain-containing
Schistosoma japonicum Sjp_0126020   IPR000568,ATPase, F0 complex, subunit A,domain-containing
Schistosoma japonicum Sjp_0126430   IPR000568,ATPase, F0 complex, subunit A,domain-containing
Schistosoma japonicum Sjp_0128800   IPR000568,ATPase, F0 complex, subunit A,domain-containing
Schistosoma mansoni ATP6   ATP synthase F0 subunit 6
Wolbachia endosymbiont of Brugia malayi Wbm0460   ATP synthase F0F1 subunit A

Essentiality

MUL_3960 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b3738 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium tuberculosis Probable ATP synthase a chain AtpB (protein 6) Compounds References
Schistosoma mansoni ATP synthase F0 subunit 6 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0253 1 0.5
0.0225 1 0.5
0.0234 0.2534 1
0.0221 0.4692 1
0.0224 0.9619 1
0.0213 0.2604 0.9249
0.0212 0.2554 1
0.0246 0.8564 1
0.0223 0.8368 1
0.0213 0.2604 0.9249
0.0214 0.2559 1
0.0239 0.7006 0.5
0.0234 1 1
0.0226 1 0.5
0.0231 0.8361 1
0.0217 1 1
0.0213 0.2604 0.9249
0.0217 0.4517 1
0.0223 0.2568 1
0.0213 0.8388 1
0.0212 0.2554 1
0.0213 0.2604 0.9249
0.0243 1 0.5
0.0225 1 0.5
0.0204745 0.749299 1
0.022 0.9595 1
0.0262 1 1
0.0262 1 0.5
0.0225 0.2761 1
0.0229 0.3345 1
0.0213 0.2604 0.9249
0.0246 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_3960 (Mycobacterium ulcerans), F0F1 ATP synthase subunit A
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