Detailed view for MUP040c

Basic information

TDR Targets ID: 954920
Mycobacterium ulcerans, Type I modular polyketide synthase

Source Database / ID:  KEGG  

pI: 5.55 | Length (AA): 16990 | MW (Da): 1799587 | Paralog Number: 12

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00109   Beta-ketoacyl synthase, N-terminal domain
PF00550   Phosphopantetheine attachment site
PF00698   Acyl transferase domain
PF02801   Beta-ketoacyl synthase, C-terminal domain
PF08659   KR domain
PF13602   Zinc-binding dehydrogenase
PF14765   Polyketide synthase dehydratase
PF16197   Ketoacyl-synthetase C-terminal extension

Gene Ontology

Mouse over links to read term descriptions.
GO:0031177   phosphopantetheine binding  
GO:0016740   transferase activity  
GO:0016491   oxidoreductase activity  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 79 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
18 445 4na1 (A) 5 460 44.00 0 1 0.587491 -0.76
18 511 4qyr (A) 2545 3037 44.00 0 1 0.451376 -0.26
20 602 4oqj (A) 20 578 40.00 0 1 0.408614 0.02
430 907 3tzy (A) 599 1057 23.00 0 1 0.248134 -0.44
469 888 5yda (A) 5 396 36.00 0 1 0.41702 -0.46
566 884 4rl1 (A) 28 351 32.00 0 1 0.524876 -1.38
567 849 5dz7 (A) 3 276 26.00 0 1 0.310657 -0.32
567 846 1nm2 (A) 3 282 35.00 0 1 0.37778 -0.15
568 849 5dz7 (A) 4 276 34.00 0 1 0.408898 -0.46
928 1222 3el6 (A) 8 275 39.00 0 1 0.469463 -0.94
932 1238 5o15 (A) 19 306 34.00 0 1 0.362069 -0.82
1344 1673 5ktk (A) 115 462 28.00 0.000000000034 1 0.300723 -0.35
1447 1619 5c37 (A) 1888 2061 31.00 0.0000000025 1 0.481482 -0.95
1494 1604 3pgx (A) 70 186 34.00 0.0011 0.66 0.305833 0.33
1526 2721 6fij (A) 120 1273 30.00 0 1 0.275694 0.51
1720 1797 2mf4 (A) 6734 6810 32.00 0.0028 1 0.522891 -1.32
1816 2239 1e5m (A) 6 414 25.00 0 1 0.241956 -0.45
1817 2253 4opf (A) 6121 6542 35.00 0 1 0.238721 -0.21
2736 3033 6mbh (A) 1702 1983 20.00 0 0.8 0.12754 -0.18
3244 3469 4piv (A) 1879 2103 27.00 0 1 0.389402 -0.68
3526 3604 2mr7 (A) 8 83 29.00 0.00062 1 0.45575 -1.13
3528 3603 2md9 (A) 14 86 21.00 0.00037 0.97 0.366573 -1.17
3619 4526 2hg4 (A) 36 899 55.00 0 1 0.659743 -0.6
4075 4515 4qbu (A) 8 443 28.00 0 1 0.376056 -0.72
4177 4494 4rl1 (A) 29 351 47.00 0 1 0.647717 -1.52
4999 5358 3krt (A) 12 417 26.00 0.0084 1 0.0564889 0.31
5048 5363 5dp1 (A) 5 334 41.00 0 1 0.525899 -0.71
5158 5332 4oki (A) 671 849 41.00 0 1 0.5536 -0.97
5289 5605 5d2e (A) 196 507 27.00 0 1 0.255758 0.01
5368 5546 2c07 (A) 62 244 21.00 0.0000000052 0.99 0.248636 -0.31
5369 5567 3edm (C) 6 237 22.00 0.0000013 1 0.342813 -0.93
5369 5594 5f1p (A) 5 244 30.00 0.055 0.83 0.184602 0.18
5371 5614 3ioy (A) 8 300 18.00 0.0042 0.98 0.176461 -0.06
5504 6655 6fij (A) 132 1280 26.00 0 1 0.267905 0.38
5649 5724 1t8k (A) 2 77 22.00 0.62 0.93 0.401573 -1.06
5713 6649 6c9u (A) 6 910 53.00 0 1 0.66425 -0.61
5740 6163 2iwz (A) 39 456 27.00 0 1 0.300256 -0.39
6659 6915 3hrq (A) 1309 1579 13.00 0.0000000025 0.65 0.0782265 0.2
7176 7381 3ksu (A) 11 234 19.00 0.00026 1 0.302225 -0.52
7439 7532 2liu (A) 1938 2033 27.00 0 0.94 0.341533 -0.73
7454 7528 2n98 (A) 11 87 36.00 0.76 0.9 0.460714 -0.5
7547 8447 6c9u (A) 32 910 55.00 0 1 0.704331 -0.75
7547 9512 2vz8 (A) 2 2106 26.00 0 1 0.243815 0.4
9553 9640 6c4q (A) 11 93 28.00 0.000016 1 0.35528 -0.52
9562 9643 4neo (A) 7 85 22.00 0.014 1 0.427926 -1.75
9565 9641 1x3o (A) 2 78 29.00 0.53 1 0.502632 -1.5
9659 10546 4mz0 (A) 36 936 45.00 0 1 0.580566 -0.52
10203 10507 3qat (A) 3 311 31.00 0 1 0.369952 -0.81
10205 10510 2cuy (A) 4 304 39.00 0 1 0.451011 -0.59
10566 11076 4l4x (A) 14 528 42.00 0 1 0.461077 -0.41
10567 11081 4imp (A) 15 529 41.00 0 1 0.506312 -0.52
10600 11730 2uv8 (A) 404 1737 15.00 0 1 -0.101431 1
10740 11850 3hmj (A) 600 1882 16.00 0 1 -0.119609 1.17
11089 11181 2ju1 (A) 2 94 44.00 0 1 0.569474 -0.82
11098 11177 2mr7 (A) 1 77 31.00 0.95 0.96 0.454009 -0.97
11169 12099 4mz0 (A) 12 936 40.00 0 1 0.518897 -0.46
11200 11624 1e5m (A) 6 415 25.00 0 1 0.307115 -0.64
11201 12099 2qo3 (A) 31 907 53.00 0 1 0.639913 -0.58
11201 11791 4ope (B) 4224 4793 34.00 0 1 0.350785 -0.19
12111 12406 4ln9 (A) 14 294 37.00 0 1 0.464522 -0.99
12885 12970 2ju1 (A) 5 90 51.00 0.000000000021 1 0.671362 -0.8
12896 12974 4hkg (A) 3 80 32.00 0 1 0.50065 -1.47
12898 12999 1j3m (A) 5 92 39.00 0.12 1 0.300304 0.22
12994 14959 2vz8 (A) 2 2112 25.00 0 1 0.224715 0.53
14213 14970 3slk (A) 1 743 49.00 0 1 0.577715 -0.05
14523 14698 4oki (A) 670 849 41.00 0 1 0.563459 -1.05
14739 14909 1ae1 (A) 25 200 22.00 0.000033 1 0.237165 -0.19
15015 15089 2ehs (A) 1 75 28.00 0.035 0.99 0.493514 -1.52
15110 15530 4jrm (D) 6 413 26.00 0 1 0.320079 -0.59
15110 15530 3ho9 (A) 5 411 27.00 0 1 0.282079 -0.31
15224 15530 3e60 (A) 107 417 33.00 0 1 0.303369 -0.09
15662 15950 1nm2 (A) 2 290 30.00 0 1 0.40911 -0.64
16026 16319 5il6 (A) 4371 4644 24.00 0 1 0.272404 -0.47
16213 16764 5c37 (A) 1202 2105 20.00 0 1 0.14249 0.22
16428 16775 5ktk (A) 101 466 25.00 0 1 0.306583 -0.58
16543 16703 2ae2 (A) 11 172 24.00 0.00038 1 0.331576 -0.74
16806 16897 5hv8 (A) 2047 2138 96.00 0 1 1.17341 -1.66
16818 16928 1klp (A) 4 115 22.00 0.027 0.71 0.210633 0.05
16823 16895 4hkg (A) 9 80 35.00 0.0000012 1 0.590397 -1.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126633)

Species Accession Gene Product
Brugia malayi Bm1_08575   Beta-ketoacyl synthase, N-terminal domain containing protein
Brugia malayi Bm1_35180   oxidoreductase, zinc-binding dehydrogenase family protein
Caenorhabditis elegans CELE_F32H2.5   Protein FASN-1
Cryptosporidium hominis Chro.30258   hypothetical protein
Cryptosporidium hominis Chro.40330   hypothetical protein
Cryptosporidium parvum cgd4_2900   polyketide synthase
Cryptosporidium parvum cgd3_2180   type I fatty acid synthase
Dictyostelium discoideum DDB_G0281475   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0284001   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0271000   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0271614   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0291684   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290703   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0271530   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0288457   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0275077   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0291614   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0271618   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0271524   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290709   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0293912   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290729   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0295667   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0272981   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0275069   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0283931   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290943   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0271662   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290853   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290701   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290469   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0269364   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0270572   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0287095   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0291604   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0273007   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290937   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0282029   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0272859   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0282027   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0287119   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0292544   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0295659   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0293902   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290467   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290699   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0271520   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290737   beta-ketoacyl synthase family protein
Drosophila melanogaster Dmel_CG3523   CG3523 gene product from transcript CG3523-RA
Drosophila melanogaster Dmel_CG17374   CG17374 gene product from transcript CG17374-RC
Drosophila melanogaster Dmel_CG3524   CG3524 gene product from transcript CG3524-RB
Homo sapiens ENSG00000169710   fatty acid synthase
Loa Loa (eye worm) LOAG_12875   acyl carrier protein
Loa Loa (eye worm) LOAG_12856   hypothetical protein
Loa Loa (eye worm) LOAG_05412   fatty acid synthase
Loa Loa (eye worm) LOAG_06344   hypothetical protein
Loa Loa (eye worm) LOAG_05695   hypothetical protein
Mycobacterium leprae ML2353c   PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE
Mycobacterium leprae ML2356c   PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB
Mycobacterium leprae ML1229   PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4
Mycobacterium leprae ML2357c   PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA
Mycobacterium leprae ML2354c   PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD
Mycobacterium leprae ML0101   Polyketide synthase Pks13
Mycobacterium leprae ML0139   Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas
Mycobacterium leprae ML2355c   PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC
Mycobacterium leprae ML0135   Probable polyketide synthase Pks1
Mus musculus ENSMUSG00000025153   fatty acid synthase
Mycobacterium tuberculosis Rv2931   Phenolpthiocerol synthesis type-I polyketide synthase PpsA
Mycobacterium tuberculosis Rv2933   Phenolpthiocerol synthesis type-I polyketide synthase PpsC
Mycobacterium tuberculosis Rv2934   Phenolpthiocerol synthesis type-I polyketide synthase PpsD
Mycobacterium tuberculosis Rv2940c   Probable multifunctional mycocerosic acid synthase membrane-associated Mas
Mycobacterium tuberculosis Rv1527c   Probable polyketide synthase Pks5
Mycobacterium tuberculosis Rv1180   Probable polyketide beta-ketoacyl synthase Pks3
Mycobacterium tuberculosis Rv1181   Probable polyketide beta-ketoacyl synthase Pks4
Mycobacterium tuberculosis Rv2048c   Polyketide synthase Pks12
Mycobacterium tuberculosis Rv3800c   Polyketide synthase Pks13
Mycobacterium tuberculosis Rv0405   Probable membrane bound polyketide synthase Pks6
Mycobacterium tuberculosis Rv1661   Probable polyketide synthase Pks7
Mycobacterium tuberculosis Rv1662   Probable polyketide synthase Pks8
Mycobacterium tuberculosis Rv2935   Phenolpthiocerol synthesis type-I polyketide synthase PpsE
Mycobacterium tuberculosis Rv2932   Phenolpthiocerol synthesis type-I polyketide synthase PpsB
Mycobacterium tuberculosis Rv1664   Probable polyketide synthase Pks9
Mycobacterium tuberculosis Rv2947c   Probable polyketide synthase Pks15
Mycobacterium tuberculosis Rv2946c   Probable polyketide synthase Pks1
Mycobacterium tuberculosis Rv3825c   Polyketide synthase Pks2
Mycobacterium ulcerans MUP039c   Type I modular polyketide synthase
Mycobacterium ulcerans MUL_2018   phenolpthiocerol synthesis type-I polyketide synthase PpsB
Mycobacterium ulcerans MUP040c   Type I modular polyketide synthase
Mycobacterium ulcerans MUL_2005   polyketide synthase
Mycobacterium ulcerans MUL_1655   polyketide synthase Pks9
Mycobacterium ulcerans MUL_2016   phenolpthiocerol synthesis type-I polyketide synthase PpsD
Mycobacterium ulcerans MUL_2010   multifunctional mycocerosic acid synthase membrane-associated Mas
Mycobacterium ulcerans MUL_2015   phenolpthiocerol synthesis type-I polyketide synthase PpsE
Mycobacterium ulcerans MUP032c   Type I modular polyketide synthase
Mycobacterium ulcerans MUL_2266   polyketide synthase
Mycobacterium ulcerans MUL_2019   phenolpthiocerol synthesis type-I polyketide synthase PpsA
Mycobacterium ulcerans MUL_4983   polyketide synthase Pks13
Mycobacterium ulcerans MUL_2017   phenolpthiocerol synthesis type-I polyketide synthase PpsC
Neospora caninum NCLIV_001690   Short-chain dehydrogenase/reductase SDR, related
Neospora caninum NCLIV_020690   Soraphen polyketide synthase A, related
Neospora caninum NCLIV_050890   KR domain domain-containing protein, putative
Onchocerca volvulus OVOC1839  
Onchocerca volvulus OVOC5784   Fatty acid synthase homolog
Schmidtea mediterranea mk4.052433.01  
Toxoplasma gondii TGME49_294820   type I fatty acid synthase, putative
Toxoplasma gondii TGME49_204560   type I fatty acid synthase, putative
Toxoplasma gondii TGME49_326200   type I fatty acid synthase
Toxoplasma gondii TGME49_236990   beta-ketoacyl synthase, N-terminal domain-containing protein
Toxoplasma gondii TGME49_236980   AMP-binding enzyme domain-containing protein

Essentiality

MUP040c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2988 Mycobacterium tuberculosis non-essential nmpdr
mtu3867 Mycobacterium tuberculosis essential nmpdr
mtu408 Mycobacterium tuberculosis non-essential nmpdr
mtu1690 Mycobacterium tuberculosis essential nmpdr
mtu1691 Mycobacterium tuberculosis essential nmpdr
mtu2981 Mycobacterium tuberculosis non-essential nmpdr
CELE_F32H2.5 Caenorhabditis elegans embryonic arrest wormbase
CELE_F32H2.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_F32H2.5 Caenorhabditis elegans larval arrest wormbase
CELE_F32H2.5 Caenorhabditis elegans sterile wormbase
TGME49_294820 Toxoplasma gondii Essentiality uncertain sidik
TGME49_204560 Toxoplasma gondii Essentiality uncertain sidik
TGME49_236990 Toxoplasma gondii Essentiality uncertain sidik
TGME49_236980 Toxoplasma gondii Essentiality uncertain sidik
TGME49_326200 Toxoplasma gondii Essentiality uncertain sidik
TGME49_294820 Toxoplasma gondii Probably non-essential sidik
TGME49_204560 Toxoplasma gondii Probably non-essential sidik
TGME49_236990 Toxoplasma gondii Probably non-essential sidik
TGME49_236980 Toxoplasma gondii Probably non-essential sidik
TGME49_326200 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus fatty acid synthase Compounds References
Gallus gallus Fatty acid synthase Compounds References
Homo sapiens fatty acid synthase Compounds References
Rattus norvegicus Fatty acid synthase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Staphylococcus aureus 3-oxoacyl-[acyl-carrier-protein] synthase 2 403 aa 25.8% 360 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.4178 0.5259 0.6676
0.0025 0.4383 0.5834
0.0683 0.4348 0.582
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.1164 0.4337 0.581
0.1186 0.5205 0.6547
0.1377 0.4577 0.6023
0.0382 0.4982 0.6023
0.0302 0.3626 0.6524
0.0305 0.4383 0.5834
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.0101 0.4361 0.5834
0.003 0.4361 0.5834
0.0351 0.4383 0.5834
0.003 0.4361 0.5834
0.0051 0.4207 0.5656
0.0663 0.425 0.5723
0.066 0.5205 0.6547
0.003 0.4361 0.5834
0.0107 0.4383 0.5834
0.0991 0.4577 0.6023
0.0113 0.4383 0.5834
0.139 0.4901 0.6023
0.003 0.3096 0.3249
0.032 0.4333 0.5806
0.0907 0.3203 0.6575
0.0722 0.4254 0.5727
0.0102 0.4361 0.5834
0.0273 0.4133 0.5834
0.0805 0.4361 0.5834
0.003 0.3956 0.4065
0.003 0.4361 0.5834
0.0026 0.4383 0.5834
0.0047 0.2667 0
0.0273 0.4133 0.5834
0.0172 0.3982 0.6202
0.0033 0.4035 0.5505
0.0027 0.4062 0.581
0.0074 0.2913 0.581
0.0126 0.4361 0.5834
0.1046 0.4557 0.6023
0.0208 0.423 0.6023
0.003 0.4361 0.5834
0.0934 0.4383 0.5834
0.0653 0.3947 0.6631
0.0234 0.2842 0.6547
0.0131 0.4337 0.581
0.0627 0.52 0.6617
0.0429 0.371 0.6023
0.0077 0.2952 0.5834
0.0134 0.4361 0.5834
0.0051 0.4337 0.581
0.0546 0.5208 0.661
0.0891 0.5107 0.6473
0.003 0.4361 0.5834
0.0251 0.4383 0.5834
0.1088 0.5174 0.6559
0.0168 0.411 0.5834
0.0627 0.52 0.6617
0.0016 0.4337 0.581
0.0199 0.4361 0.5834
0.0076 0.4361 0.5834
0.0356 0.4361 0.5834
0.0322 0.4337 0.581
0.0718 0.5001 0.6442
0.003 0.4361 0.5834
0.0419 0.4255 0.5728
0.003 0.3075 0.581
0.006 0.4207 0.5656
0.0409 0.5182 0.6576
0.0382 0.4982 0.6023
0.0627 0.52 0.6617
0.0553 0.3511 0.5834
0.0625 0.4364 0.5834
0.0051 0.251 0.0623
0.0602 0.4383 0.5834
0.1075 0.4493 0.4377
0.0845 0.4349 0.5822
0.0689 0.524 0.6547
0.003 0.4361 0.5834
0.0259 0.4577 0.6023
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.0405 0.4652 0.6547
0.003 0.4361 0.5834
0.003 0.4337 0.581
0.0025 0.2982 0.4065
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.0596 0.4383 0.5834
0.0133 0.4383 0.5834
0.0087 0.3979 0.581
0.003 0.4361 0.5834
0.0339 0.4383 0.5834
0.1393 0.5143 0.6547
0.0687 0.4348 0.582
0.0381 0.4383 0.5834
0.0278 0.4327 0.58
0.1151 0.4577 0.6023
0.1161 0.5074 0.6451
0.1016 0.4383 0.5834
0.003 0.4361 0.5834
0.003 0.4358 0.581
0.0076 0.4337 0.581
0.003 0.4361 0.5834
0.0627 0.52 0.6617
0.0727 0.4247 0.572
0.003 0.4361 0.5834
0.1423 0.512 0.6547
0.1278 0.4555 0.6023
0.003 0.3268 0.3249
0.0575 0.4361 0.5834
0.1338 0.5174 0.6547
0.0701 0.5082 0.6517
0.034 0.4909 0.5939
0.0231 0.4383 0.5834
0.0544 0.4574 0.459
0.0907 0.3031 0.5834
0.043 0.4383 0.5834
0.095 0.4383 0.5834
0.0536 0.3705 0.6106
0.0071 0.2948 0
0.0131 0.4361 0.5834
0.01 0.4383 0.5834
0.1099 0.4361 0.5834
0.1053 0.4383 0.5834
0.0777 0.5246 0.6547
0.1099 0.4361 0.5834
0.0123 0.4889 0.6224
0.003 0.3075 0.581
0.0133 0.4229 0.4065
0.003 0.2514 0.4065
0.0627 0.52 0.6617
0.0185 0.4555 0.6023
0.0325 0.442 0.5834
0.0995 0.3108 0.6635
0.0891 0.5107 0.6473
0.3462 0.5258 0.6675
0.003 0.2982 0.4065
0.0659 0.2618 0.6625
0.003 0.4361 0.5834
0.0086 0.4555 0.6023
0.003 0.4383 0.5834
0.0167 0.2713 0.6023
0.0392 0.3524 0.5834
0.0844 0.4349 0.5822
0.0731 0.501 0.6451
0.0567 0.4555 0.6023
0.0056 0.4036 0.5481
0.1125 0.479 0.6451
0.003 0.4361 0.5834
0.1086 0.4383 0.5834
0.0631 0.4425 0.5834
0.0026 0.4383 0.5834
0.0197 0.4758 0.5982
0.0234 0.4175 0.6023
0.003 0.2783 0.4065
0.0024 0.3995 0.4065
0.077 0.501 0.6451
0.0627 0.52 0.6617
0.0106 0.4337 0.581
0.0026 0.4383 0.5834
0.0227 0.4555 0.6023
0.0162 0.4383 0.5834
0.0976 0.3334 0.6547
0.003 0.4361 0.5834
0.0633 0.4591 0.6638
0.0059 0.4361 0.5834
0.006 0.4183 0.5656
0.003 0.4349 0.5822
0.0636 0.4246 0.5719
0.1488 0.5168 0.6507
0.1187 0.4577 0.6023
0.003 0.4337 0.581
0.0536 0.3705 0.6106
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.0679 0.5237 0.6657
0.003 0.4361 0.5834
0.003 0.4003 0.5834
0.003 0.4062 0.581
0.015 0.4298 0.5771
0.0937 0.4254 0.5727
0.1243 0.4383 0.5834
0.0621 0.4361 0.5834
0.044 0.4341 0.5814
0.0654 0.2554 0.6631
0.0025 0.4383 0.5834
0.0101 0.4308 0.6023
0.0701 0.5082 0.6517
0.0742 0.5225 0.6562
0.003 0.4229 0.4065
0.003 0.4361 0.5834
0.0286 0.4275 0.5726
0.0058 0.4337 0.581
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.1425 0.486 0.6023
0.0029 0.3995 0.4065
0.0627 0.52 0.6617
0.0638 0.2624 0.5834
0.003 0.4361 0.5834
0.0287 0.4919 0.6023
0.0087 0.4229 0.5689
0.0806 0.4349 0.5822
0.003 0.4361 0.5834
0.0078 0.4361 0.5834
0.016 0.4229 0.5542
0.0078 0.4383 0.5834
0.0796 0.4383 0.5834
0.003 0.4383 0.4989
0.003 0.4062 0.581
0.0302 0.3626 0.6524
0.0891 0.5107 0.6473
0.003 0.4361 0.5834
0.0166 0.4889 0.6023
0.0018 0.4337 0.581
0.132 0.5252 0.6658
0.003 0.3727 0.4065
0.0672 0.4361 0.5834
0.0471 0.4204 0.4204
0.003 0.4361 0.5834
0.0558 0.4321 0.5794
0.1099 0.4361 0.5834
0.1164 0.4337 0.581
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.1006 0.4921 0.6023
0.003 0.4361 0.5834
0.003 0.4337 0.581
0.0153 0.4464 0.5912
0.0629 0.374 0.6618
0.003 0.4361 0.5834
0.2144 0.3671 0.6672
0.0159 0.4383 0.5834
0.1152 0.4555 0.6023
0.0131 0.3996 0.5834
0.003 0.4307 0.581
0.003 0.4337 0.581
0.0968 0.4555 0.6023
0.032 0.4333 0.5806
0.1075 0.4493 0.4377
0.1052 0.4504 0.5834
0.0074 0.4337 0.581
0.0503 0.5051 0.6488
0.0531 0.4383 0.5834
0.0701 0.5082 0.6517
0.003 0.3075 0.581
0.003 0.4361 0.5834
0.0086 0.4361 0.5834
0.0948 0.4383 0.5834
0.0889 0.4383 0.5834
0.0701 0.5082 0.6517
0.0995 0.3108 0.6635
0.1252 0.525 0.6657
0.058 0.4383 0.5834
0.0739 0.4794 0.5918
0.0409 0.5182 0.6576
0.4115 0.525 0.6567
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.006 0.4207 0.5656
0.0705 0.383 0.5834
0.003 0.4044 0.5834
0.095 0.4361 0.5834
0.0166 0.4889 0.6023
0.003 0.4062 0.581
0.1338 0.5174 0.6547
0.006 0.4207 0.5656
0.003 0.3075 0.581
0.0903 0.461 0.6076
0.0028 0.4229 0.4065
0.013 0.4361 0.5834
0.0115 0.3243 0.1689
0.003 0.4361 0.5834
0.4115 0.525 0.6567
0.0785 0.4349 0.5821
0.003 0.4361 0.5834
0.1052 0.4504 0.5834
0.003 0.4361 0.5834
0.0871 0.4806 0.5931
0.003 0.4065 0.5834
0.003 0.3644 0.4065
0.0187 0.3995 0.4065
0.0502 0.4291 0.5764
0.1423 0.512 0.6547
0.0653 0.3947 0.6631
0.0163 0.4555 0.6023
0.068 0.2696 0.6634
0.0056 0.4361 0.5834
0.003 0.4361 0.5834
0.0187 0.3995 0.4065
0.0425 0.4383 0.5834
0.0781 0.4241 0.5714
0.0101 0.4361 0.5834
0.0382 0.4982 0.6023
0.0074 0.4383 0.5834
0.0115 0.3243 0.1689
0.031 0.4383 0.5834
0.1338 0.5174 0.6547
0.003 0.4361 0.5834
0.119 0.4383 0.5834
0.0627 0.52 0.6617
0.0425 0.4383 0.5834
0.003 0.4361 0.5834
0.0935 0.4577 0.6023
0.0995 0.3111 0.6635
0.003 0.4337 0.581
0.003 0.3935 0.6023
0.065 0.259 0.6631
0.0082 0.4036 0.5481
0.003 0.3958 0.581
0.0656 0.4024 0.6627
0.0225 0.4394 0.5834
0.003 0.4361 0.5834
0.0655 0.2631 0.6625
0.0503 0.4253 0.5726
0.0328 0.4361 0.5834
0.003 0.3348 0.581
0.003 0.4309 0.581
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.0679 0.5237 0.6657
0.003 0.4361 0.5834
0.003 0.4328 0.4065
0.003 0.3299 0.4065
0.3865 0.5253 0.667
0.0633 0.4591 0.6638
0.0603 0.4361 0.5834
0.003 0.4361 0.5834
0.0715 0.5145 0.6547
0.0134 0.4555 0.6023
0.0852 0.4249 0.5722
0.0051 0.4337 0.581
0.0055 0.4229 0.4579
0.0569 0.4249 0.5722
0.01 0.4383 0.5834
0.0664 0.4383 0.5834
0.1088 0.5174 0.6559
0.003 0.4062 0.581
0.0137 0.4337 0.581
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.1224 0.4577 0.6023
0.0352 0.4361 0.5834
0.065 0.4067 0.6625
0.0055 0.4361 0.5834
0.0054 0.4229 0.4065
0.1338 0.5174 0.6547
0.1069 0.4882 0.6015
0.0139 0.4337 0.581
0.1099 0.4361 0.5834
0.003 0.4361 0.5834
0.0237 0.3669 0.5834
0.003 0.3956 0.55
0.0409 0.5182 0.6576
0.132 0.5252 0.6658
0.0566 0.4346 0.5819
0.0656 0.5067 0.6451
0.2144 0.3671 0.6672
0.0673 0.4383 0.5834
0.0025 0.4229 0.4065
0.0206 0.5154 0.6547
0.1075 0.4493 0.4377
0.0139 0.3397 0.5834
0.003 0.4361 0.5834
0.0075 0.4361 0.5834
0.003 0.4361 0.5834
0.0453 0.4522 0.597
0.0827 0.5069 0.6451
0.0357 0.4361 0.5834
0.1409 0.5187 0.6547
0.1074 0.3173 0.6633
0.003 0.4337 0.581
0.065 0.259 0.6631
0.0213 0.4025 0.5495
0.006 0.4207 0.5656
0.1252 0.525 0.6657
0.003 0.4361 0.5834
0.0907 0.3203 0.6575
0.4115 0.525 0.6567
0.0154 0.4555 0.6023
0.1069 0.4882 0.6015
0.0049 0.4337 0.581
0.003 0.4361 0.5834
0.0679 0.5237 0.6657
0.003 0.4337 0.581
0.0995 0.3108 0.6635
0.0102 0.4361 0.5834
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.0663 0.4383 0.5834
0.1488 0.5168 0.6507
0.072 0.4555 0.6023
0.0748 0.425 0.5723
0.1377 0.4577 0.6023
0.006 0.4207 0.5656
0.003 0.4062 0.581
0.003 0.4361 0.5834
0.0075 0.4361 0.5834
0.003 0.4062 0.581
0.0181 0.4889 0.63
0.005 0.4361 0.5834
0.015 0.4361 0.5834
0.0153 0.4361 0.5834
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.0226 0.4337 0.581
0.0234 0.2842 0.6547
0.0075 0.2615 0.6016
0.0029 0.4383 0.5834
0.003 0.4337 0.581
0.0112 0.2594 0.5834
0.0536 0.3705 0.6106
0.0485 0.5064 0.6451
0.0525 0.4361 0.5834
0.0506 0.4344 0.5817
0.003 0.4361 0.5834
0.0075 0.4361 0.5834
0.4115 0.525 0.6567
0.003 0.4062 0.581
0.0452 0.4383 0.5834
0.0052 0.4361 0.5834
0.0029 0.4383 0.5834
0.0075 0.3046 0.5834
0.0621 0.4361 0.5834
0.0029 0.2681 0.581
0.0053 0.3106 0.4065
0.0239 0.4113 0.556
0.0633 0.4649 0.6626
0.003 0.4361 0.5834
0.05 0.4361 0.5834
0.0695 0.4209 0.6627
0.0586 0.4345 0.5818
0.0776 0.4383 0.5834
0.0662 0.4347 0.582
0.003 0.4062 0.581
0.0679 0.5022 0.6371
0.0208 0.2719 0.581
0.003 0.3268 0.3249
0.0503 0.432 0.5793
0.003 0.3096 0.5834
0.0457 0.4383 0.5834
0.0536 0.3705 0.6106
0.0837 0.4245 0.5719
0.003 0.4337 0.581
0.0051 0.4337 0.581
0.0577 0.2963 0.5834
0.003 0.4337 0.581
0.003 0.3995 0.3452
0.0101 0.4361 0.5834
0.1022 0.4383 0.5834
0.0024 0.3192 0.5834
0.0648 0.5206 0.6547
0.0582 0.4383 0.5834
0.2144 0.5242 0.6547
0.0904 0.4285 0.5736
0.0026 0.4337 0.581
0.0101 0.4877 0.6023
0.003 0.3727 0.4065
0.0667 0.4076 0.6629
0.0644 0.446 0.5931
0.099 0.4361 0.5834
0.0167 0.4337 0.581
0.0679 0.5237 0.6657
0.003 0.4361 0.5834
0.022 0.4361 0.5834
0.105 0.4383 0.5834
0.0025 0.4229 0.4065
0.066 0.4763 0.6627
0.0777 0.5246 0.6547
0.0731 0.501 0.6451
0.003 0.4361 0.5834
0.1317 0.4577 0.6023
0.065 0.3963 0.6627
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.0055 0.4207 0.5656
0.0656 0.5067 0.6451
0.0074 0.2913 0.581
0.0025 0.4229 0.4065
0.1274 0.5113 0.6545
0.0705 0.383 0.5834
0.0132 0.4411 0.5834
0.003 0.4361 0.5834
0.0536 0.3705 0.6106
0.0223 0.3995 0.454
0.003 0.4337 0.581
0.0075 0.4361 0.5834
0.0891 0.5107 0.6473
0.0391 0.4361 0.5834
0.006 0.4207 0.5656
0.0958 0.4361 0.5834
0.0234 0.2842 0.6547
0.003 0.4361 0.5834
0.095 0.4361 0.5834
0.0536 0.3705 0.6106
0.003 0.3956 0.4065
0.0154 0.2644 0.2622
0.0487 0.5225 0.6594
0.3908 0.5248 0.6661
0.0544 0.4574 0.459
0.0053 0.4361 0.5834
0.0292 0.4852 0.6023
0.0976 0.3334 0.6547
0.003 0.4328 0.4065
0.0154 0.4577 0.6023
0.0536 0.3705 0.6106
0.0315 0.4521 0.5834
0.003 0.3865 0.4555
0.0961 0.5007 0.6376
0.0564 0.5224 0.6635
0.0852 0.4249 0.5722
0.0328 0.4334 0.5807
0.003 0.3995 0.3452
0.003 0.4062 0.581
0.0661 0.4026 0.6627
0.044 0.4889 0.6023
0.0887 0.4251 0.5724
0.01 0.4036 0.5481
0.003 0.4361 0.5834
0.0503 0.432 0.5793
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.0025 0.3423 0.3423
0.0055 0.4337 0.581
0.003 0.4062 0.581
0.1099 0.4361 0.5834
0.003 0.4337 0.581
0.0484 0.4265 0.5738
0.003 0.4337 0.581
0.0154 0.4093 0.554
0.003 0.4337 0.581
0.016 0.4361 0.5834
0.445 0.5259 0.6675
0.003 0.4361 0.5834
0.0081 0.2513 0.6023
0.003 0.4361 0.5834
0.0063 0.4229 0.5647
0.003 0.4337 0.581
0.003 0.4117 0.5834
0.0803 0.5098 0.6451
0.062 0.5242 0.6623
0.006 0.4207 0.5656
0.0044 0.3417 0.5834
0.0024 0.2516 0.3643
0.003 0.4361 0.5834
0.003 0.4361 0.5834
0.1383 0.501 0.6451
0.003 0.4361 0.5834
0.094 0.5233 0.6652
0.0793 0.2757 0.2736
0.0033 0.4361 0.5834
0.0133 0.4383 0.5834
0.0441 0.4361 0.5834
0.1022 0.4383 0.5834
0.003 0.4361 0.5834
0.015 0.4361 0.5834
0.0278 0.4361 0.5834
0.1377 0.4577 0.6023
0.003 0.4361 0.5834
0.0627 0.52 0.6617
0.0934 0.4383 0.5834
0.0324 0.33 0.6545
0.0976 0.3334 0.6547
0.0329 0.4334 0.5807
0.01 0.3212 0
0.003 0.4361 0.5834
0.0988 0.4337 0.581
0.0286 0.4725 0.5924
0.003 0.4337 0.581
0.006 0.4183 0.5656
0.1125 0.479 0.6451
0.0558 0.4321 0.5794
0.0639 0.4887 0.6206
0.003 0.4062 0.581
0.0057 0.4337 0.581
0.006 0.4207 0.5656
0.003 0.4361 0.5834
0.4177 0.5035 0.6442
0.0086 0.4229 0.4065
0.0681 0.501 0.6451
0.0255 0.2953 0.3072
0.0629 0.374 0.6618
0.0293 0.4337 0.581
0.069 0.5246 0.6614
0.003 0.4361 0.5834
0.0556 0.5113 0.6545
0.003 0.4337 0.581
0.0097 0.3189 0.2947

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

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Gene identifier MUP040c (Mycobacterium ulcerans), Type I modular polyketide synthase
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