Detailed view for MUL_4142

Basic information

TDR Targets ID: 955163
Mycobacterium ulcerans, flavodoxin reductase Hmp
Source Database / ID:  KEGG  

pI: 4.2577 | Length (AA): 358 | MW (Da): 38203 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00111   2Fe-2S iron-sulfur cluster binding domain
PF00175   Oxidoreductase NAD-binding domain
PF00970   Oxidoreductase FAD-binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0051537   2 iron, 2 sulfur cluster binding  
GO:0051536   iron-sulfur cluster binding  
GO:0016491   oxidoreductase activity  
GO:0009055   electron carrier activity  
GO:0055114   oxidation reduction  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 356 2pia (A) 3 321 24.00 0 1 1.17417 0.43
72 184 3vo2 (A) 93 225 36.00 0.016 0.96 0.514742 0.6
269 358 4itk (A) 2 91 32.00 0 1 0.752597 -1.01
272 358 1frr (A) 5 91 34.00 0 1 0.745217 -0.82

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130710)

Species Accession Gene Product
Candida albicans CaO19.11192   one of three likely flavohemoproteins similar to S. pombe SPAC869.02c and S. cerevisiae YHB1 (YGR234W) NADPH-dependent flavohemo
Candida albicans CaO19.3707   one of three likely flavohemoproteins similar to S. pombe SPAC869.02c and S. cerevisiae YHB1 (YGR234W) NADPH-dependent flavohemo
Dictyostelium discoideum DDB_G0292380   hypothetical protein
Dictyostelium discoideum DDB_G0292378   hypothetical protein
Escherichia coli b2552   fused nitric oxide dioxygenase/dihydropteridine reductase 2
Giardia lamblia GL50803_15009   Flavohemoprotein lateral transfer candidate
Mycobacterium tuberculosis Rv3571   Reductase component of 3-ketosteroid-9-alpha-hydroxylase KshB
Mycobacterium ulcerans MUL_4142   flavodoxin reductase Hmp
Saccharomyces cerevisiae YGR234W   Yhb1p

Essentiality

MUL_4142 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2552 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_4142 (Mycobacterium ulcerans), flavodoxin reductase Hmp
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