pI: 8.0638 |
Length (AA): 249 |
MW (Da): 26375 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 244 | 1xu9 (A) | 32 | 275 | 23.00 | 0 | 1 | 1.28362 | -0.6 |
1 | 224 | 2jah (A) | 5 | 224 | 31.00 | 0 | 1 | 1.382 | -1.04 |
3 | 223 | 3tjr (A) | 10 | 249 | 25.00 | 0 | 1 | 1.31695 | -1.21 |
3 | 92 | 3rd5 (A) | 14 | 94 | 41.00 | 0.0021 | 0.71 | 0.719446 | -0.07 |
4 | 249 | 2fr0 (A) | 1666 | 1911 | 20.00 | 0 | 1 | 1.14565 | -0.02 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_130166)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_09265 | Dehydrogenases, short chain protein 30 |
Caenorhabditis elegans | CELE_T25G12.7 | Protein DHS-30 |
Caenorhabditis elegans | CELE_T25G12.13 | Protein T25G12.13 |
Caenorhabditis elegans | CELE_T25G12.2 | Protein T25G12.2 |
Drosophila melanogaster | Dmel_CG7601 | CG7601 gene product from transcript CG7601-RA |
Giardia lamblia | GL50803_8382 | Short-chain dehydrogenase, putative |
Homo sapiens | ENSG00000109016 | dehydrogenase/reductase (SDR family) member 7B |
Leishmania braziliensis | LbrM.35.3640 | short chain dehydrogenase-like protein |
Leishmania donovani | LdBPK_363570.1 | short chain dehydrogenase-like protein |
Leishmania infantum | LinJ.36.3570 | short chain dehydrogenase-like protein |
Leishmania major | LmjF.36.3410 | short chain dehydrogenase-like protein |
Leishmania mexicana | LmxM.36.3410 | short chain dehydrogenase-like protein |
Loa Loa (eye worm) | LOAG_13677 | dehydrogenase |
Loa Loa (eye worm) | LOAG_12558 | hypothetical protein |
Mus musculus | ENSMUSG00000042569 | dehydrogenase/reductase (SDR family) member 7B |
Mycobacterium tuberculosis | Rv3391 | Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 |
Mycobacterium tuberculosis | Rv0945 | Probable short-chain type dehydrogenase/reductase |
Mycobacterium tuberculosis | Rv1050 | Probable oxidoreductase |
Mycobacterium ulcerans | MUL_4417 | short chain dehydrogenase |
Mycobacterium ulcerans | MUL_4346 | multi-functional enzyme with acyl-CoA-reductase activity AcrA1 |
Mycobacterium ulcerans | MUL_0918 | short chain dehydrogenase |
Mycobacterium ulcerans | MUL_3139 | short-chain dehydrogenase |
Oryza sativa | 4329454 | Os02g0511400 |
Oryza sativa | 4350557 | Os11g0499600 |
Schmidtea mediterranea | mk4.005667.01 | |
Schmidtea mediterranea | mk4.010259.00 | |
Trypanosoma brucei gambiense | Tbg972.11.11250 | short-chain dehydrogenase, putative |
Trypanosoma brucei | Tb927.11.10020 | short-chain dehydrogenase, putative |
Trypanosoma congolense | TcIL3000_0_45550 | short-chain dehydrogenase, putative |
Trypanosoma congolense | TcIL3000.11.10540 | short-chain dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.509749.39 | short-chain dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.510719.20 | short-chain dehydrogenase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu3451 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb11.01.1780 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.1780 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.1780 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.1780 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Macaca mulatta | Hydroxysteroid 11-beta dehydrogenase 1 | 140 aa | 25.2% | 139 aa | Compounds | References |