pI: 4.8564 |
Length (AA): 124 |
MW (Da): 13159 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 123 | 3uf8 (A) | 0 | 113 | 48.00 | 0 | 1 | 1.61844 | -0.79 |
2 | 124 | 1q6h (A) | 110 | 224 | 41.00 | 0 | 1 | 1.48164 | -0.74 |
27 | 124 | 2pbc (A) | 41 | 137 | 44.00 | 0 | 1 | 1.39602 | -1 |
35 | 102 | 1ix5 (A) | 8 | 87 | 43.00 | 0.0000029 | 0.99 | 0.821087 | 0.49 |
50 | 94 | 3jym (A) | 60 | 118 | 51.00 | 0.00028 | 0.6 | 0.829603 | 0.06 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126727)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G25230 | rotamase FKBP 1 |
Arabidopsis thaliana | AT5G45680 | peptidyl-prolyl cis-trans isomerase FKBP13 |
Arabidopsis thaliana | AT5G48570 | peptidyl-prolyl cis-trans isomerase FKBP65 |
Brugia malayi | Bm1_49010 | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 |
Brugia malayi | Bm1_56870 | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 |
Candida albicans | CaO19_6452 | hypothetical protein |
Candida albicans | CaO19.13810 | one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes |
Candida albicans | CaO19.3702 | one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes |
Candida albicans | CaO19.11186 | one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes |
Candida albicans | CaO19.6452 | one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes |
Caenorhabditis elegans | CELE_F31D4.3 | Protein FKB-6 |
Caenorhabditis elegans | CELE_Y18D10A.19 | Protein FKB-2 |
Dictyostelium discoideum | DDB_G0283815 | hypothetical protein |
Dictyostelium discoideum | DDB_G0275227 | FKBP-type peptidylprolyl cis-trans isomerase |
Drosophila melanogaster | Dmel_CG11001 | FK506-binding protein 2 |
Drosophila melanogaster | Dmel_CG4535 | FK506-binding protein FKBP59 |
Echinococcus granulosus | EgrG_001185900 | peptidyl prolyl cis trans isomerase FKBP4 |
Echinococcus granulosus | EgrG_001186200 | peptidyl prolyl cis trans isomerase FKBP4 |
Echinococcus granulosus | EgrG_000334550 | peptidyl prolyl cis trans isomerase FKBP1A |
Entamoeba histolytica | EHI_051870 | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative |
Entamoeba histolytica | EHI_178850 | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative |
Echinococcus multilocularis | EmuJ_001186200 | peptidyl prolyl cis trans isomerase FKBP4 |
Echinococcus multilocularis | EmuJ_000334550 | fk506 binding protein |
Echinococcus multilocularis | EmuJ_001185900 | peptidyl prolyl cis trans isomerase FKBP4 |
Giardia lamblia | GL50803_10450 | FKBP-type peptidyl-prolyl cis-trans isomerase |
Giardia lamblia | GL50803_3643 | 70 kDa peptidylprolyl isomerase, putative |
Homo sapiens | ENSG00000096060 | FK506 binding protein 5 |
Homo sapiens | ENSG00000004478 | FK506 binding protein 4, 59kDa |
Homo sapiens | ENSG00000119782 | FK506 binding protein 1B, 12.6 kDa |
Homo sapiens | ENSG00000088832 | FK506 binding protein 1A, 12kDa |
Leishmania braziliensis | LbrM.19.1790 | peptidylprolyl isomerase-like protein |
Leishmania braziliensis | LbrM.22.1310 | fk506-binding protein 1-like protein |
Leishmania donovani | LdBPK_191560.1 | peptidylprolyl isomerase-like protein |
Leishmania donovani | LdBPK_221280.1 | fk506-binding protein 1-like protein |
Leishmania infantum | LinJ.19.1560 | peptidylprolyl isomerase-like protein |
Leishmania infantum | LinJ.22.1280 | fk506-binding protein 1-like protein |
Leishmania major | LmjF.19.1530 | peptidylprolyl isomerase-like protein |
Leishmania major | LmjF.22.1430 | fk506-binding protein 1-like protein |
Leishmania mexicana | LmxM.22.1430 | fk506-binding protein 1-like protein |
Leishmania mexicana | LmxM.19.1530 | peptidylprolyl isomerase-like protein |
Loa Loa (eye worm) | LOAG_03265 | FKBP5 protein |
Loa Loa (eye worm) | LOAG_13106 | hypothetical protein |
Loa Loa (eye worm) | LOAG_02491 | FKBP-type peptidyl-prolyl cis-trans isomerase-12 |
Mus musculus | ENSMUSG00000024222 | FK506 binding protein 5 |
Mus musculus | ENSMUSG00000032966 | FK506 binding protein 1a |
Mus musculus | ENSMUSG00000020635 | FK506 binding protein 1b |
Mus musculus | ENSMUSG00000030357 | FK506 binding protein 4 |
Mycobacterium ulcerans | MUL_2502 | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase |
Neospora caninum | NCLIV_028870 | Peptidylprolyl isomerase D (Cyclophilin D), related |
Oryza sativa | 4329388 | Os02g0491400 |
Oryza sativa | 4335556 | Os04g0352400 |
Oryza sativa | 4341766 | Os06g0663800 |
Oryza sativa | 4346090 | Os08g0525600 |
Plasmodium berghei | PBANKA_1460400 | peptidyl-prolyl cis-trans isomerase FKBP35, putative |
Plasmodium falciparum | PF3D7_1247400 | peptidyl-prolyl cis-trans isomerase FKBP35 |
Plasmodium knowlesi | PKNH_1467100 | peptidyl-prolyl cis-trans isomerase FKBP35, putative |
Plasmodium vivax | PVX_101260 | 70 kDa peptidylprolyl isomerase, putative |
Plasmodium yoelii | PY02360 | FK506-binding protein |
Saccharomyces cerevisiae | YNL135C | peptidylprolyl isomerase FPR1 |
Schistosoma japonicum | Sjp_0025140 | ko:K09568 FK506-binding protein 1, putative |
Schistosoma japonicum | Sjp_0127020 | FK506-binding protein 1A, putative |
Schistosoma japonicum | Sjp_0016730 | ko:K09571 FK506-binding protein 4/5, putative |
Schistosoma mansoni | Smp_079230 | immunophilin FK506 binding protein FKBP12 |
Schistosoma mansoni | Smp_004780.1 | immunophilin |
Schistosoma mansoni | Smp_004780.3 | immunophilin |
Schistosoma mansoni | Smp_004780.2 | immunophilin |
Schmidtea mediterranea | mk4.002275.03 | Peptidyl-prolyl cis-trans isomerase |
Schmidtea mediterranea | mk4.002452.06 | Peptidyl-prolyl cis-trans isomerase |
Schmidtea mediterranea | mk4.054209.00 | 39 kDa FK506-binding nuclear protein |
Schmidtea mediterranea | mk4.000763.00 | Peptidyl prolyl cis trans isomerase FKBP-1 |
Trypanosoma brucei gambiense | Tbg972.10.19710 | peptidylprolyl isomerase-like protein, putative |
Trypanosoma brucei gambiense | Tbg972.7.3750 | peptidyl-prolyl cis-trans isomerase, putative |
Trypanosoma brucei | Tb927.7.3420 | peptidyl-prolyl cis-trans isomerase, putative |
Trypanosoma brucei | Tb927.10.16100 | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative |
Trypanosoma congolense | TcIL3000_0_03850 | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative |
Trypanosoma congolense | TcIL3000_7_2670 | peptidyl-prolyl cis-trans isomerase, putative |
Trypanosoma cruzi | TcCLB.508323.84 | peptidyl-prolyl cis-trans isomerase, putative |
Trypanosoma cruzi | TcCLB.511353.10 | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative |
Trypanosoma cruzi | TcCLB.511825.63 | peptidyl-prolyl cis-trans isomerase, putative |
Trypanosoma cruzi | TcCLB.511301.70 | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative |
Treponema pallidum | TP0862 | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) |
Theileria parva | TP02_0901 | peptidyl-prolyl cis-trans isomerase, putative |
Trichomonas vaginalis | TVAG_413760 | fk506-binding protein, putative |
Trichomonas vaginalis | TVAG_292580 | immunophilin, putative |
Trichomonas vaginalis | TVAG_476140 | peptidylprolyl isomerase, putative |
Trichomonas vaginalis | TVAG_368970 | peptidylprolyl isomerase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.3420 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.3420 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.3420 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.7.3420 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.16100 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.16100 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.16100 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.16100 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F31D4.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F31D4.3 | Caenorhabditis elegans | larval arrest | wormbase |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | FK506 binding protein 1A, 12kDa | Compounds | References |
Rattus norvegicus | FK506-binding protein 1A | Compounds | References |
Gallus gallus | FK506 binding protein 12 | Compounds | References |
Legionella pneumophila | Outer membrane protein MIP | Compounds | References |
Homo sapiens | FK506 binding protein 1B, 12.6 kDa | Compounds | References |
Homo sapiens | FK506 binding protein 5 | Compounds | References |
Homo sapiens | FK506 binding protein 4, 59kDa | Compounds | References |