Detailed view for EmuJ_000813400

Basic information

TDR Targets ID: 955702
Echinococcus multilocularis, Glycosyltransferase protein LARGE1
Source Database / ID:  GeneDB

pI: 9.5478 | Length (AA): 353 | MW (Da): 39936 | Paralog Number: 5

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01501   Glycosyl transferase family 8

Gene Ontology

Mouse over links to read term descriptions.
GO:0016757   transferase activity, transferring glycosyl groups  

Metabolic Pathways

Mannose type O-glycan biosynthesis (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
56 179 3kj6 (A) 110 318 31.00 0.17 0.03 0.404775 1.42
98 329 4wlm (A) 100 356 23.00 0 1 0.833524 0.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130765)

Species Accession Gene Product
Brugia malayi Bm1_40530   Glycosyl transferase family 8 protein
Caenorhabditis elegans CELE_K09C8.4   Protein LGE-1
Echinococcus granulosus EgrG_000813400   Glycosyltransferase protein LARGE1
Echinococcus granulosus EgrG_000813500   glycosyltransferase protein LARGE2
Echinococcus granulosus EgrG_000768900   Glycosyl transferase family 8
Echinococcus multilocularis EmuJ_000813400   Glycosyltransferase protein LARGE1
Echinococcus multilocularis EmuJ_000769200   glycosyltransferase protein LARGE2
Echinococcus multilocularis EmuJ_000275300   glycosyltransferase protein LARGE2
Echinococcus multilocularis EmuJ_000813500   glycosyltransferase protein LARGE2
Echinococcus multilocularis EmuJ_000769100   conserved hypothetical protein
Echinococcus multilocularis EmuJ_000768900   Glycosyl transferase, family 8
Homo sapiens ENSG00000133424   like-glycosyltransferase
Homo sapiens ENSG00000165905   glycosyltransferase-like 1B
Loa Loa (eye worm) LOAG_02214   glycosyl transferase family 8 protein
Mus musculus ENSMUSG00000004383   like-glycosyltransferase
Mus musculus ENSMUSG00000040434   glycosyltransferase-like 1B
Schistosoma japonicum Sjp_0018360   ko:K09668 glycosyltransferase-like protein LARGE, putative
Schistosoma mansoni Smp_146640   glycosyltransferase-related
Schmidtea mediterranea mk4.000005.01  
Schmidtea mediterranea mk4.000005.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens like-glycosyltransferase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0053 0.6524 0
0.0063 0.5899 0.67
0.0064 0.5899 0.6822
0.0059 0.3503 0.48
0.0064 0.3609 0.3609
0.0059 0.3503 0.48
0.0064 0.3835 0.3835
0.0056 0.2748 0.3944
0.0059 0.3503 0.48
0.0064 0.5093 0
0.0064 0.2773 0.4708
0.0059 0.3503 0.48

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000813400 (Echinococcus multilocularis), Glycosyltransferase protein LARGE1
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