pI: 7.5902 |
Length (AA): 1830 |
MW (Da): 205257 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
395 | 755 | 3ghm (A) | 300 | 681 | 30.00 | 0 | 1 | 0.299368 | 1.37 |
464 | 528 | 5ftt (A) | 241 | 304 | 42.00 | 0.000000015 | 0.86 | 0.541619 | -0.21 |
475 | 527 | 5foe (A) | 1004 | 1051 | 48.00 | 0.0000026 | 0.93 | 0.547062 | -0.56 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126771)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_36565 | ADAM-TS Spacer 1 family protein |
Caenorhabditis elegans | CELE_F25H8.3 | Protein GON-1, isoform A |
Drosophila melanogaster | Dmel_CG4096 | CG4096 gene product from transcript CG4096-RB |
Drosophila melanogaster | Dmel_CG14869 | ADAM metallopeptidase with thrombospondin type 1 motif A |
Echinococcus granulosus | EgrG_001046600 | a disintegrin and metalloproteinase with |
Echinococcus multilocularis | EmuJ_001046600 | a disintegrin and metalloproteinase with |
Homo sapiens | ENSG00000049192 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 |
Homo sapiens | 9507 | ADAM metallopeptidase with thrombospondin type 1 motif, 4 |
Homo sapiens | ENSG00000136378 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 |
Homo sapiens | ENSG00000173157 | ADAM metallopeptidase with thrombospondin type 1 motif, 20 |
Homo sapiens | ENSG00000154734 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
Homo sapiens | ENSG00000142303 | ADAM metallopeptidase with thrombospondin type 1 motif, 10 |
Homo sapiens | ENSG00000166106 | ADAM metallopeptidase with thrombospondin type 1 motif, 15 |
Homo sapiens | ENSG00000163638 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 |
Homo sapiens | ENSG00000145536 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 |
Homo sapiens | ENSG00000140873 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 |
Homo sapiens | ENSG00000151388 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
Homo sapiens | ENSG00000134917 | ADAM metallopeptidase with thrombospondin type 1 motif, 8 |
Homo sapiens | ENSG00000154736 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
Loa Loa (eye worm) | LOAG_03946 | hypothetical protein |
Mus musculus | ENSMUSG00000022893 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 |
Mus musculus | ENSMUSG00000024299 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10 |
Mus musculus | ENSMUSG00000030022 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9 |
Mus musculus | ENSMUSG00000053399 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18 |
Mus musculus | ENSMUSG00000032363 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7 |
Mus musculus | ENSMUSG00000022449 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20 |
Mus musculus | ENSMUSG00000031994 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 |
Mus musculus | ENSMUSG00000046169 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6 |
Mus musculus | ENSMUSG00000006403 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 |
Mus musculus | ENSMUSG00000033453 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15 |
Mus musculus | ENSMUSG00000049538 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16 |
Mus musculus | ENSMUSG00000047497 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 |
Mus musculus | ENSMUSG00000022894 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) |
Oryza sativa | 4327737 | Os01g0610800 |
Schistosoma japonicum | Sjp_0011910 | ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative |
Schistosoma mansoni | Smp_124500 | ADAMTS5 peptidase (M12 family) |
Schmidtea mediterranea | mk4.001563.04 | Disintegrin/metalloproteinase with thrombospondin motifs-1 |
Schmidtea mediterranea | mk4.000218.14 | ADAMTS peptidase |
Schmidtea mediterranea | mk4.000218.06 | A disintegrin and metalloproteinase with thrombospondin motifs gon-1 |
Schmidtea mediterranea | mk4.000218.11 | |
Schmidtea mediterranea | mk4.000218.13 | ADAMTS peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F25H8.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F25H8.3 | Caenorhabditis elegans | sterile | wormbase |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | Compounds | References |
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | Compounds | References |
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | Compounds | References |