Detailed view for EmuJ_001184200

Basic information

TDR Targets ID: 956148
Echinococcus multilocularis, protein will die slowly
Source Database / ID:  GeneDB

pI: 7.7145 | Length (AA): 324 | MW (Da): 36145 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 323 2h9l (A) 16 333 78.00 0 1 1.97998 -1.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128632)

Species Accession Gene Product
Arabidopsis thaliana AT3G49660   COMPASS-like H3K4 histone methylase component WDR5A
Brugia malayi Bm1_28000   Will die slowly protein
Candida albicans CaO19.10961   WD40 repeat protein similar to S. cerevisiae SWD3 (YBR175W) COMPASS histone methyltransferase complex component
Candida albicans CaO19.3457   WD40 repeat protein similar to S. cerevisiae SWD3 (YBR175W) COMPASS histone methyltransferase complex component
Caenorhabditis elegans CELE_C14B1.4   Protein WDR-5.1
Dictyostelium discoideum DDB_G0287273   WD40 repeat-containing protein
Drosophila melanogaster Dmel_CG17437   will die slowly
Echinococcus granulosus EgrG_001184200   protein will die slowly
Echinococcus multilocularis EmuJ_001184200   protein will die slowly
Homo sapiens ENSG00000196363   WD repeat domain 5
Homo sapiens ENSG00000196981   WD repeat domain 5B
Loa Loa (eye worm) LOAG_03831   WD40 repeat protein
Mus musculus ENSMUSG00000026917   WD repeat domain 5
Mus musculus ENSMUSG00000034379   WD repeat domain 5B
Oryza sativa 4333964   Os03g0725400
Onchocerca volvulus OVOC3321  
Saccharomyces cerevisiae YBR175W   Swd3p
Schistosoma japonicum Sjp_0094150   WD repeat-containing protein 5, putative
Schistosoma mansoni Smp_046750   hypothetical protein
Schmidtea mediterranea mk4.002606.02  
Schmidtea mediterranea mk4.004394.01  
Trichomonas vaginalis TVAG_032580   WD repeat domain, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens WD repeat domain 5 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1107 0.2948 0.2935
0.0279 0.3133 0.3921
0.0081 0.8549 0.8549
0.028 0.322 0.3672
0.0418 1 1
0.1176 1 1
0.04 0.9926 1
0.0488 1 0.5
0.0081 0.8549 0.8549
0.0841 1 1
0.1352 1 1
0.0277 0.2882 0.3579
0.0549 0.6599 0.6599
0.0727 0.8086 0.808
0.0759 1 1
0.0288 0.285 0.3386
0.1345 0.5 0.5
0.0886 1 1
0.1596 1 1
0.2017 0.8233 1
0.015 1 1
0.0081 0.8549 0.8549
0.0564 1 1
0.0066 0.3838 0.3798
0.029 0.2725 0.3405
0.0348 1 1
0.1218 1 1
0.0543 0.36 0.36
0.0755 1 1
0.1095 1 1
0.0133 0.2522 0.2488
0.1023 1 1
0.0074 0.46 0.4498
0.0749 0.7129 0.7129
0.0996 1 1
0.0135 0.6423 0.6423
0.0898 1 1
0.042 1 1
0.0765 1 1
0.0066 0.3975 0.3975
0.0424 1 1
0.0922 1 1
0.0751 1 1
0.0081 0.8549 0.8549
0.0278 0.4804 0.4793
0.1107 0.2948 0.2935
0.0376 0.4734 0.4734
0.0081 0.8549 0.8549
0.0081 0.3714 0.3714
0.0289 0.308 0.3065
0.0072 0.4458 0.4458
0.041 1 1
0.0484 1 1
0.1501 1 1
0.0415 1 1
0.029 0.2737 0.3428
0.04 0.9926 1
0.0293 0.3098 0.3076
0.1265 1 1
0.0899 1 1
0.0373 0.4415 0.4415
0.014 0.5117 0.8819
0.0564 1 1
0.064 0.998 0.998
0.0368 1 1
0.0554 1 1
0.1095 1 1
0.0276 0.2809 0.2809
0.1095 1 1
0.1653 1 1
0.0923 1 1
0.0618 1 1
0.1517 1 1
0.0383 0.2503 0.2497
0.0417 1 1
0.1695 1 1
0.2017 0.8233 1
0.0633 0.8194 1
0.1795 1 1
0.0146 0.7498 0.7125
0.0737 0.2578 0.2578
0.0274 0.3557 0.4417
0.0637 1 1
0.0418 1 1
0.0316 0.4664 0.5023
0.0555 1 1
0.0131 0.5494 0.5494
0.0282 0.2662 0.2643
0.1107 1 1
0.0275 1 1
0.0364 1 1
0.1135 1 1
0.0411 1 1
0.014 0.3671 0.3379
0.0638 1 1
0.057 1 1
0.055 1 1
0.1335 1 0.5
0.0622 1 1
0.0274 0.3266 0.3254
0.0205 1 1
0.0737 0.2578 0.2578
0.0564 1 1
0.0416 1 1
0.0569 1 1
0.0886 1 1
0.0081 1 0.5
0.0081 1 1
0.0141 0.8299 0.8259
0.0292 0.2878 0.3603
0.0926 1 1
0.0135 0.2573 0.3357
0.1107 0.2948 0.2935
0.2005 1 1
0.03 0.5 0.5
0.0434 1 1
0.014 0.3671 0.3379
0.0635 1 1
0.0515 0.376 0.376
0.0942 1 1
0.028 0.322 0.3672
0.1023 1 1
0.085 1 1
0.0355 0.8515 0.8465
0.0066 0.3429 0.3429
0.0549 0.5 0.5
0.1107 1 1
0.0081 0.8549 0.8549
0.0135 0.2573 0.3357
0.1167 1 1
0.0081 0.5393 0.5393
0.0846 0.4549 0.4544
0.039554 0.373928 0.461753
0.0424 1 1
0.0625 1 1
0.0416 1 1
0.02 1 1
0.1646 1 1
0.1064 1 1
0.0737 0.2578 0.2578
0.0418 1 1
0.0274 0.3557 0.4417
0.1107 0.2948 0.2935
0.0423 1 0.5
0.0515 0.376 0.376
0.0213 1 1
0.1391 1 1
0.0293 0.2595 0.3116
0.1107 1 1
0.092 1 1
0.0291 0.2595 0.3201
0.0721 1 1
0.0081 0.8549 0.8549
0.0418 1 1
0.0281 0.3238 0.3311
0.0564 1 1
0.187 1 1
0.1577 1 1
0.1245 1 1
0.1083 0.6752 1
0.0205 0.7189 1
0.0737 0.2578 0.2578
0.0665 1 1
0.035 1 1
0.0289 0.308 0.3065
0.0418 1 1
0.0564 1 1
0.0289 1 1
0.2017 0.8233 1
0.1107 0.2948 0.2935
0.0886 1 1
0.0689 1 1
0.0081 0.3004 1
0.0704 1 1
0.0205 0.7189 1
0.0287 0.2621 0.2614
0.04 0.9926 1
0.0811 1 1
0.0365 0.5 0.5
0.0282 0.2681 0.2643
0.0131 0.7569 0.7514
0.0081 0.8549 0.8549
0.0133 0.2552 0.2409
0.0292 0.2782 0.3478
0.0373 0.8444 1
0.0418 1 1
0.0307 0.3037 0.3783
0.0851 1 1
0.0205 0.7189 1
0.1352 1 1
0.0971 1 1
0.0737 0.2578 0.2578
0.0374723 0.376882 0.467568
0.0287 0.5 0.5
0.179 1 1
0.1357 1 1
0.0206 1 1
0.0564 1 1
0.0149 1 1
0.0775 0.9274 0.9274
0.141 1 1
0.0776 0.9296 0.9296
0.02 0.2749 0.3282
0.1468 1 1
0.0332 1 1
0.0081 0.8549 0.8549
0.0404 0.5634 0.5634
0.0633 0.8194 1
0.0291 0.2784 0.3487
0.0365 1 0.5
0.0272 0.2781 0.3478
0.0721 1 1
0.2005 1 1
0.0422 1 1
0.1695 1 1
0.0293 0.3098 0.3076
0.039554 0.373928 0.461753
0.1107 0.2948 0.2935
0.0633 0.8194 1
0.1095 1 1
0.0628 1 1
0.0081 0.8549 0.8549
0.0143 0.3942 0.3891
0.0133 0.4193 0.5176
0.0081 0.2526 0.2526
0.1631 1 1
0.0351 1 1
0.0423 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_001184200 (Echinococcus multilocularis), protein will die slowly
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