pI: 4.5935 |
Length (AA): 740 |
MW (Da): 81076 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
44 | 419 | 5btr (A) | 151 | 511 | 53.00 | 0 | 1 | 1.04491 | -0.49 |
107 | 407 | 4iao (A) | 230 | 530 | 44.00 | 0 | 1 | 0.975557 | -0.92 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129944)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_38355 | NAD-dependent deacetylase SIRT1 |
Candida albicans | CaO19.4761 | one of two genes similar to S. cerevisiae SIR2 (YDL042C) NAD+-dependent histone deacetylase |
Candida albicans | CaO19.12225 | one of two genes similar to S. cerevisiae SIR2 (YDL042C) NAD+-dependent histone deacetylase |
Caenorhabditis elegans | CELE_R11A8.4 | Protein SIR-2.1, isoform B |
Dictyostelium discoideum | DDB_G0289967 | NAD(+)-dependent deacetylase, silent information regulator protein family protein |
Drosophila melanogaster | Dmel_CG5216 | CG5216 gene product from transcript CG5216-RA |
Echinococcus granulosus | EgrG_000698900 | NAD dependent deacetylase sirtuin 1 |
Echinococcus multilocularis | EmuJ_000698900 | NAD dependent deacetylase sirtuin 1 |
Giardia lamblia | GL50803_10707 | NAD-dependent histone deacetylase Sir2 |
Homo sapiens | ENSG00000096717 | sirtuin 1 |
Loa Loa (eye worm) | LOAG_06360 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10594 | hypothetical protein |
Mus musculus | ENSMUSG00000020063 | sirtuin 1 |
Saccharomyces cerevisiae | YOL068C | Hst1p |
Saccharomyces cerevisiae | YDL042C | Sir2p |
Schistosoma japonicum | Sjp_0032180 | ko:K01463 sirtuin 1 (silent mating type information regulation 2, homolog) 1 [EC:3.5.1.-], putative |
Schistosoma japonicum | Sjp_0130490 | expressed protein |
Schistosoma mansoni | Smp_138640 | chromatin regulatory protein sir2 |
Schmidtea mediterranea | mk4.010263.00 | NAD-dependent protein deacetylase sir-2.1 |
Trichomonas vaginalis | TVAG_026260 | chromatin regulatory protein sir2, putative |
Trichomonas vaginalis | TVAG_549940 | chromatin regulatory protein sir2, putative |
Trichomonas vaginalis | TVAG_319320 | chromatin regulatory protein sir2, putative |
Trichomonas vaginalis | TVAG_190210 | chromatin regulatory protein sir2, putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | sirtuin 1 | Compounds | References |
Saccharomyces cerevisiae | Sir2p | Compounds | References |