Detailed view for EmuJ_001170100

Basic information

TDR Targets ID: 956829
Echinococcus multilocularis, histone lysine methyltransferase setb histone lysine methyltransferase eggless

Source Database / ID:  GeneDB

pI: 6.9983 | Length (AA): 972 | MW (Da): 106761 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00856   SET domain
PF01429   Methyl-CpG binding domain
PF05033   Pre-SET motif

Gene Ontology

Mouse over links to read term descriptions.
GO:0034968   GO:histone lysine methylation  

GO:0005634   nucleus  
GO:0018024   histone-lysine N-methyltransferase activity  
GO:0008270   zinc ion binding  
GO:0005515   protein binding  
GO:0003677   DNA binding  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
197 380 4nj5 (A) 357 524 35.00 0 0.92 0.3617 1.21
233 438 1mvh (A) 217 416 34.00 0 1 0.390334 1.23
325 382 3bo5 (A) 101 158 55.00 0 0.98 0.556071 1.43
545 595 4w2p (A) 72 127 33.00 0.65 0.26 0.317869 -0.08
873 968 2w5y (A) 3875 3965 37.00 0 0.5 0.202165 1.65

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131012)

Species Accession Gene Product
Brugia malayi Bm1_19995   Pre-SET motif family protein
Caenorhabditis elegans CELE_R05D3.11   Protein MET-2
Drosophila melanogaster Dmel_CG12196   eggless
Echinococcus granulosus EgrG_001170100   histone lysine methyltransferase setb
Echinococcus granulosus EgrG_001170200   histone lysine n methyltransferase setb1
Echinococcus granulosus EgrG_002008500   5'partial|histone lysine N methyltransferase SETDB2
Echinococcus multilocularis EmuJ_001170100   histone lysine methyltransferase setb histone lysine methyltransferase eggless
Echinococcus multilocularis EmuJ_001170200   histone lysine n methyltransferase setb1
Homo sapiens ENSG00000143379   SET domain, bifurcated 1
Homo sapiens ENSG00000136169   SET domain, bifurcated 2
Loa Loa (eye worm) LOAG_09398   hypothetical protein
Loa Loa (eye worm) LOAG_08874   hypothetical protein
Mus musculus ENSMUSG00000071350   SET domain, bifurcated 2
Mus musculus ENSMUSG00000015697   SET domain, bifurcated 1
Schistosoma japonicum Sjp_0309720   Histone-lysine N-methyltransferase eggless, putative
Schistosoma japonicum Sjp_0311920   expressed protein
Schistosoma japonicum Sjp_0052060   Histone-lysine N-methyltransferase eggless, putative
Schistosoma japonicum Sjp_0052080   Histone-lysine N-methyltransferase SETDB1-B, putative
Schistosoma mansoni Smp_150850.1   histone-lysine n-methyltransferase setb1
Schistosoma mansoni Smp_150850.2   histone-lysine n-methyltransferase setb1
Schmidtea mediterranea mk4.001106.07   Histone-lysine N-methyltransferase met-2
Schmidtea mediterranea mk4.006052.00   Putative histone-lysine n-methyltransferase, setb1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens SET domain, bifurcated 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0141 0.2654 0.3317
0.0464 0.2635 0.2635
0.0157 0.2555 1
0.0464 0.2635 0.2635
0.0093 0.3728 0.3728
0.0368 0.2744 0.3936

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_001170100 (Echinococcus multilocularis), histone lysine methyltransferase setb histone lysine methyltransferase eggless
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