Detailed view for EmuJ_000477200

Basic information

TDR Targets ID: 957073
Echinococcus multilocularis, cathepsin L
Source Database / ID:  GeneDB

pI: 7.3865 | Length (AA): 348 | MW (Da): 38831 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00112   Papain family cysteine protease

Gene Ontology

Mouse over links to read term descriptions.
GO:0008234   cysteine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

Lysosome (KEGG)
Apoptosis (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
27 347 4qrv (A) 7 317 41.00 0 1 1.29531 -0.1
32 348 1cs8 (A) 1 220 43.00 0 1 1.38362 -0.5
127 347 4yyw (A) 1 217 44.00 0 1 1.20096 -1.03
128 348 2p86 (A) 2 214 54.00 0 1 1.28096 -0.73
128 347 8pch (A) 2 210 47.00 0 1 1.26008 -0.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131680)

Species Accession Gene Product
Caenorhabditis elegans CELE_F54G2.1   Protein F54G2.1, isoform B
Drosophila melanogaster Dmel_CG32381   CG32381 gene product from transcript CG32381-RC
Echinococcus granulosus EgrG_000477200   cathepsin L
Echinococcus multilocularis EmuJ_000477200   cathepsin L
Homo sapiens ENSG00000007516   BAI1-associated protein 3
Homo sapiens ENSG00000092929   unc-13 homolog D (C. elegans)
Mus musculus ENSMUSG00000047507   BAI1-associated protein 3
Mus musculus ENSMUSG00000057948   unc-13 homolog D (C. elegans)
Schistosoma japonicum Sjp_0044890   Cathepsin L1, putative
Schistosoma japonicum Sjp_0019430   BAI1-associated protein 3, putative
Schistosoma japonicum Sjp_0019460   IPR000276,Rhodopsin-like GPCR superfamily;IPR008973,C2 calcium/lipid-binding region, CaLB,domain-containing
Schistosoma japonicum Sjp_0132650   ko:K01365 cathepsin L [EC3.4.22.15], putative
Schistosoma japonicum Sjp_0316280   expressed protein
Schistosoma japonicum Sjp_0116670   Cathepsin L1, putative
Schistosoma japonicum Sjp_0203390   expressed protein
Schistosoma mansoni Smp_157090   subfamily C1A unassigned peptidase (C01 family)
Schmidtea mediterranea mk4.016741.00   Subfamily C1A unassigned peptidase
Schmidtea mediterranea mk4.030605.00   Subfamily C1A unassigned peptidase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Carica papaya Papain 345 aa 36.4% 352 aa Compounds References
Dermatophagoides pteronyssinus Peptidase 1 320 aa 26.5% 332 aa Compounds References
Rattus norvegicus Cathepsin K 329 aa 38.9% 334 aa Compounds References
Capra hircus Cathepsin H 335 aa 41.7% 300 aa Compounds References
Rattus norvegicus Cathepsin S 330 aa 44.7% 284 aa Compounds References
Oryctolagus cuniculus Cathepsin K 329 aa 37.3% 354 aa Compounds References
Rattus norvegicus Cathepsin L 334 aa 48.2% 274 aa Compounds References
Bos taurus Cathepsin L 334 aa 49.8% 277 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000477200 (Echinococcus multilocularis), cathepsin L
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