pI: 8.2996 |
Length (AA): 1022 |
MW (Da): 110535 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 271 | 3o7q (A) | 31 | 266 | 20.00 | 0 | 0.37 | 0.157466 | 1.26 |
136 | 230 | 4m58 (A) | 15 | 95 | 35.00 | 0.71 | 0.16 | 0.132355 | 1.38 |
422 | 562 | 2fz1 (B) | 37 | 175 | 12.00 | 0 | 0.02 | 0.236265 | -0.19 |
726 | 777 | 5h4u (A) | 8 | 62 | 42.00 | 0.49 | 0.46 | 0.317281 | 0.41 |
841 | 912 | 3tx3 (A) | 169 | 242 | 36.00 | 0.41 | 0.69 | 0.44385 | 0.17 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127940)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_45395 | sodium-independent organic anion transporter family protein |
Brugia malayi | Bm1_19375 | sodium-independent organic anion transporter family protein |
Caenorhabditis elegans | CELE_Y70G10A.3 | Protein Y70G10A.3 |
Caenorhabditis elegans | CELE_F53B1.8 | Protein F53B1.8 |
Drosophila melanogaster | Dmel_CG31634 | Organic anion transporting polypeptide 26F |
Drosophila melanogaster | Dmel_CG3811 | Organic anion transporting polypeptide 30B |
Echinococcus granulosus | EgrG_000970200 | organic anion transporting polypeptide 30B |
Echinococcus multilocularis | EmuJ_000970200 | organic anion transporting polypeptide 30B |
Homo sapiens | ENSG00000173930 | solute carrier organic anion transporter family, member 4C1 |
Homo sapiens | ENSG00000101187 | solute carrier organic anion transporter family, member 4A1 |
Homo sapiens | ENSG00000137571 | solute carrier organic anion transporter family, member 5A1 |
Loa Loa (eye worm) | LOAG_04909 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04794 | sodium-independent organic anion transporter |
Mus musculus | ENSMUSG00000025938 | solute carrier organic anion transporter family, member 5A1 |
Mus musculus | ENSMUSG00000038963 | solute carrier organic anion transporter family, member 4a1 |
Mus musculus | 227394 | solute carrier organic anion transporter family, member 4C1 |
Onchocerca volvulus | OVOC2574 |
|
Onchocerca volvulus | OVOC8406 |
|
Schistosoma japonicum | Sjp_0300450 | Solute carrier organic anion transporter family member 5A1, putative |
Schistosoma mansoni | Smp_159140 | organic anion transporter |
Schmidtea mediterranea | mk4.000219.00 | |
Schmidtea mediterranea | mk4.024887.00 | Solute carrier organic anion transporter family member 5A1 |
Schmidtea mediterranea | mk4.001004.10 | |
Schmidtea mediterranea | mk4.016496.00 | Putative organic anion transporter |
Schmidtea mediterranea | mk4.020124.00 | Putative organic anion transporter |
Schmidtea mediterranea | mk4.001004.07 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | solute carrier organic anion transporter family, member 4C1 | Compounds | References |