Detailed view for EmuJ_000907400

Basic information

TDR Targets ID: 958002
Echinococcus multilocularis, peptidyl glycine alpha amidating monooxygenase
Source Database / ID:  GeneDB

pI: 6.3419 | Length (AA): 841 | MW (Da): 93386 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01082   Copper type II ascorbate-dependent monooxygenase, N-terminal domain
PF01436   NHL repeat
PF03712   Copper type II ascorbate-dependent monooxygenase, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016715   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen  
GO:0016020   membrane  
GO:0005515   protein binding  
GO:0005507   copper ion binding  
GO:0004497   monooxygenase activity  
GO:0003824   catalytic activity  
GO:0055114   oxidation reduction  
GO:0006518   peptide metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 291 1sdw (A) 68 350 37.00 0 1 0.711217 -0.35
316 582 3fvz (A) 498 749 41.00 0 1 0.723679 -0.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132507)

Species Accession Gene Product
Brugia malayi Bm1_41845   Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein
Caenorhabditis elegans CELE_T19B4.1   Protein PAMN-1
Drosophila melanogaster Dmel_CG12130   Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 1
Echinococcus granulosus EgrG_000907400   peptidyl glycine alpha amidating monooxygenase
Echinococcus multilocularis EmuJ_000907400   peptidyl glycine alpha amidating monooxygenase
Homo sapiens ENSG00000145730   peptidylglycine alpha-amidating monooxygenase
Loa Loa (eye worm) LOAG_02126   hypothetical protein
Mus musculus ENSMUSG00000026335   peptidylglycine alpha-amidating monooxygenase
Schistosoma japonicum Sjp_0110760   Peptidyl-glycine alpha-amidating monooxygenase precursor, putative
Schistosoma japonicum Sjp_0042880   Peptidyl-glycine alpha-amidating monooxygenase precursor, putative
Schistosoma mansoni Smp_156530   peptidyl-glycine monooxygenase
Schmidtea mediterranea mk4.000598.06   Probable peptidyl-alpha-hydroxyglycine alpha-amidating lyase
Schmidtea mediterranea mk4.000598.05   Probable peptidylglycine alpha-hydroxylating monooxygenase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Peptidyl-glycine alpha-amidating monooxygenase Compounds References
Homo sapiens peptidylglycine alpha-amidating monooxygenase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.027 0.436 0.5
0.0238 0.3604 1
0.0263 0.3028 0.3028
0.0751 0.5472 1
0.0229 0.3227 0.4262
0.0274 0.349 0.3905
0.0281 1 1
0.0123 0.3623 1
0.0253 0.2987 0.2987
0.1302 0.5262 1
0.1485 0.7935 0.7935
0.0396 0.4152 0.4144
0.1467 0.32 0.32
0.0277 0.3448 0.3446
0.0969 0.3533 0.4777
0.1713 0.4416 0.4416
0.073 0.4102 1
0.0751 0.5472 1
0.1676 0.7756 1
0.1753 0.4317 0.4294
0.0399 0.3967 0.3967
0.038 0.407 0.3785
0.1198 0.3623 0.5
0.2252 0.5269 0.6657
0.0385 0.3603 0.3603
0.1951 0.311 1
0.0228 0.42 0.42
0.025 0.2515 0.2349
0.108 1 0.5
0.1412 0.4315 0.4315
0.1389 0.2981 0.2981
0.1635 0.5261 1
0.0725 1 1
0.0236 0.3585 0.4615
0.0694 0.3943 0.3943
0.0898 0.5254 1
0.0372 0.3093 0.3093
0.1429 1 1
0.0149 0.3527 0.8524
0.1183 0.771 0.771
0.1713 0.4416 0.4416
0.0536 1 1
0.0392 0.3925 0.3925
0.0466 0.6277 0.6269
0.0244 1 1
0.16 0.5268 1
0.0253 0.2987 0.2987
0.0232 0.2978 0.2969
0.0194 0.8485 0.8456
0.0932 0.2839 0.8571
0.0222 1 1
0.12 0.2992 0.2992
0.046 0.469 0.4902
0.1186 0.421 0.421
0.0536 1 1
0.0222 1 1
0.0245 0.2619 0.2619
0.0358 0.5222 1
0.1652 0.2904 0.3336
0.0746 0.3133 0.6327
0.0948 0.4668 1
0.0718 1 1
0.0951 0.3403 0.3403
0.0228 0.7751 0
0.0369 0.3344 0.3229
0.0258 0.2862 1
0.0947 0.5187 1
0.0119 0.4195 1
0.0751 0.5472 1
0.0969 0.3533 0.4777
0.0448 0.475 0.8628
0.012 0.3587 0.3587
0.0712 0.485 0.7222
0.0121 0.2737 0.5
0.0455 0.4391 0.4391
0.0369 0.4057 0.3868
0.16 0.5268 1
0.0232 0.2522 0.2522
0.1448 0.3517 0.3515
0.071 1 1
0.0916 0.9316 0.929
0.0414 0.4751 0.5
0.0482 0.2905 0.2862
0.0259 0.2972 0.2955
0.0952 1 1
0.142 0.483 0.483
0.1206 0.3723 0.3723
0.0242 1 1
0.0248 0.2881 0.2866
0.1692 0.4589 0.4585
0.1192 0.4345 0.4328
0.0398 0.3745 0.3877
0.094 0.4876 1
0.028 0.3781 0.3764
0.2252 0.5269 0.6657
0.1131 0.4387 0.4387
0.0863 0.5253 1
0.0129 0.4934 1
0.0462 0.4352 0.4324
0.1448 0.3517 0.3515
0.0764 0.4411 0.4679
0.023 0.3652 0.28
0.0764 0.4411 0.4679
0.0229 0.3227 0.4262
0.0228 0.3093 0.3054
0.0149 0.4531 0.8119
0.0403 0.4036 0.4036
0.0244 0.4209 1
0.0746 0.5251 1
0.037 0.4075 0.3836
0.0703 1 1
0.0233 1 1
0.0704 0.4531 0.4527
0.0531 0.453 0.453
0.0691 0.8197 0.8197
0.1176 0.2988 0.2988
0.1764 0.6966 1
0.1133 0.5252 0.7288
0.2252 0.5269 0.6657
0.0394 0.5064 1
0.0244 0.4209 1
0.0191 0.4503 0.5471
0.0386 0.3607 0.3607
0.0232 0.3364 0.3364
0.0472 1 1
0.0411 0.3049 0.3049
0.0386 1 1
0.0274 0.349 0.3905
0.025 0.3197 0.3003
0.094 0.4876 1
0.0149 0.3761 0.6893
0.0709 0.2648 0.2624
0.1691 0.7083 1
0.0278 0.4031 1
0.0231 1 0.5
0.0472 0.2569 0.2569
0.0272 0.4034 1
0.0909 0.4602 1
0.0383 0.4563 0.4563
0.0231 0.2636 0.2636
0.0227 0.9531 1
0.0387 0.294 0.294
0.024 1 1
0.0448 0.2707 0.2703
0.0236 0.3585 0.4615
0.0463 0.3331 0.3313
0.0743 0.7535 0.7535
0.0958 0.3556 1
0.0227 1 1
0.0149 0.5109 1
0.1731 0.2853 0.2853
0.1176 0.2988 0.2988
0.1697 0.5249 1
0.0225 1 0.5
0.0167 0.4794 0.0137
0.4313 0.5276 0.7047
0.1434 0.3578 0.3578
0.0134 0.3737 1
0.046 1 0.5
0.0244 1 1
0.0361 0.5241 0.9707
0.1151 0.4545 1
0.142 0.483 0.483
0.0387 0.4489 0.4489
0.0225 0.5952 0.5935
0.0392 0.4474 0.4474
0.0274 0.3448 0.3446
0.0227 1 0.5
0.0274 0.3883 0.3883
0.0381 0.5069 0.8035
0.0709 0.8451 0.844
0.0226 1 1
0.2252 0.5269 0.6657
0.0269 0.3151 0.3151
0.2252 0.5269 0.6657
0.0229 1 0.5
0.0241 0.2768 0.2735
0.0392 0.4546 0.4523
0.0387 0.4524 0.4524
0.0929 0.3606 0.63
0.0703 1 1
0.0416 0.4078 1
0.012 0.3554 0
0.0381 0.2937 0.293
0.0462 0.2882 1
0.0909 0.4602 1
0.0241 0.3818 0.3817
0.0358 0.4682 1
0.0969 0.313 0.313
0.1451 0.3139 0.3137
0.0226 0.4218 0.4218
0.0494 0.3327 0.3979
0.0458 1 1
0.0691 0.8197 0.8197
0.0367 0.4163 0.3922
0.0149 0.2915 0.3163
0.1176 0.2988 0.2988
0.1198 0.3729 0.3729
0.0411 0.3049 0.3049
0.0762 0.4632 1
0.1691 0.7083 1
0.0432 0.4359 0.4359
0.0191 0.4471 0.7735
0.0269 0.2664 0.2664
0.1133 0.5252 0.7288
0.093 0.3676 0.367
0.0119 0.3802 1
0.0503 1 1
0.0228 1 1
0.147 0.523 1
0.0746 0.3133 0.6327
0.1398 0.2619 0.2618
0.0367 0.4124 0.3818
0.1591 0.5262 0.6156
0.0131 0.3909 0.6494
0.0253 1 0.5
0.0687 0.4314 0.4314
0.1183 1 1
0.0969 0.313 0.313
0.0795 1 0.5
0.1444 0.3049 0.3049
0.0126 0.404 0.5988
0.1477 0.6018 0.6018
0.0474 0.4732 0.5305
0.1436 0.6952 0.6952
0.0149 0.4848 1
0.0289 0.2822 0.2822
0.0226 0.2637 0.2637
0.0928 0.7494 1
0.1398 0.2619 0.2618
0.0121 0.4488 1
0.0275 0.4751 0.5
0.0743 0.7184 0.7184
0.0225 0.2716 0.2716
0.0225 0.2716 0.2716
0.0373 0.3241 0.311
0.0248 0.5411 0.5277
0.041 0.3541 0.336
0.0383 0.5109 0.8247
0.0123 0.484 1
0.0378 0.3456 0.3456
0.0228 0.2812 0.2812
0.0231 1 0.5
0.0959 0.321 0.321
0.0762 0.4632 1
0.1722 0.5241 1
0.0292 0.2851 0.2842
0.0228 0.2875 0.2875
0.0383 0.4529 0.4529
0.0228 0.2782 0.2781
0.094 0.3821 0.3821
0.1213 0.3623 0.5
0.0212 0.3166 0.617
0.0963 0.5256 1
0.0746 0.3133 0.6327
0.1176 0.2988 0.2988
0.0226 1 1
0.0467 0.7665 0.8869
0.0383 0.4255 0
0.113 0.4291 0.7076
0.0395 0.3237 0.3237
0.3121 0.6311 0.9757
0.1731 0.3264 0.3262
0.2252 0.5269 0.6657
0.0404 0.3882 0.3874
0.0122 0.5064 1
0.1505 0.6054 0.6053
0.041 0.3879 0.3871
0.0248 0.5411 0.5277
0.0231 0.2638 0.2638
0.0366 0.313 0.3011
0.0369 0.455 1
0.1389 0.2981 0.2981
0.0901 0.5255 1
0.0379 0.4521 0.4521
0.0274 0.349 0.3905
0.0358 0.4682 1
0.0365 0.5044 0.5044
0.0461 0.542 0.5417
0.0126 0.4558 1
0.0238 0.253 0.253
0.012 0.5051 1
0.0256 0.3851 0.6325
0.0292 0.2851 0.2842
0.1201 0.2985 0.4371
0.0227 0.3462 1
0.0121 0.2737 0.5
0.0119 0.506 0.5
0.147 1 1
0.0958 0.4676 1
0.0358 0.5222 1
0.0448 0.475 0.8628
0.0122 0.4871 0.5582
0.1398 0.2619 0.2618
0.0928 0.3318 0.3318
0.0463 1 1
0.0225 0.9788 1
0.1433 0.8703 0.8703
0.0281 0.2887 0.335
0.0396 0.4393 0.4393
0.1692 0.3459 0.3459
0.0389 0.3628 0.3628
0.0403 0.387 0.3863
0.0959 0.326 0.326
0.1389 0.2981 0.2981
0.0511 0.4666 1
0.025 0.9714 0.9894
0.013 0.2737 0.5
0.0149 0.4751 1
0.0227 0.3462 1
0.159 0.5249 1
0.1692 0.4589 0.4585
0.0401 0.4484 0.4484
0.0132 0.3623 0.5
0.0393 0.5061 1
0.0254 0.5986 0.5963
0.0375 0.3401 0.3304
0.0225 0.2716 0.2716
0.0405 0.3906 0.3906
0.1305 0.5227 1
0.0469 0.9041 0.8516
0.0929 0.3125 0.3114
0.0381 0.5069 0.8035
0.1678 0.5267 1
0.2678 0.3242 0.3242
0.0127 0.4543 1
0.1176 0.2988 0.2988
0.0376 0.291 0.291
0.0418 0.3941 0.3937
0.094 0.4876 1
0.0395 0.3904 0.3904
0.4313 0.5276 0.7047
0.0409 0.3975 0.3975
0.0225 1 1
0.0287 0.2757 0.2735
0.0241 0.2735 0.2735
0.0232 0.3364 0.3364
0.0474 0.8086 0.8086
0.1176 0.3623 0.5
0.0126 0.404 0.5988
0.0257 0.3019 0.3019
0.046 0.4404 0.4762
0.12 0.4696 1
0.0372 0.522 0.8551
0.0263 0.3028 0.3028
0.0384 0.437 0.437
0.0234 0.4257 0.3543
0.094 0.4876 1
0.0232 0.2805 0.2805
0.0947 0.5187 1
0.0268 0.5121 1
0.0408 0.5061 1
0.038 0.4156 0.3949
0.0225 0.5952 0.5935
0.0448 0.5021 1
0.0372 0.4925 0.4925
0.0266 0.473 1
0.12 0.2661 0.2661
0.076 0.5267 1
0.0268 0.5121 1
0.0764 0.4411 0.4679
0.0363 0.4959 1
0.0405 0.4027 0.4027
0.0366 0.3266 0.3266
0.0235 1 0.5
0.0696 0.4583 0.4583
0.4313 0.5276 0.7047
0.012 0.3554 0.5
0.0235 0.3155 0.3155
0.0466 0.6277 0.6269
0.1176 0.2988 0.2988
0.1193 0.3019 0.3016
0.0234 1 0.5
0.0764 0.4412 1
0.0235 0.3155 0.3155
0.2252 0.5269 0.6657
0.0707 0.3123 0.3121
0.091 0.2807 0.2724
0.0227 0.9531 1
0.0261 1 1
0.0225 0.2688 0.2683
0.0425 0.4388 0.4388
0.0947 0.5187 1
0.0369 0.455 1
0.0764 0.4411 0.4679
0.0382 0.3717 0.3668
0.0167 0.4794 0.0137
0.0692 1 1
0.0126 0.404 0.5988
0.1591 0.5275 1
0.0755 0.5253 1
0.0358 0.5222 1
0.0274 0.3448 0.3446
0.1221 0.5617 0.5616
0.0244 0.2853 1
0.0254 0.4751 0.6013
0.0704 0.4531 0.4527
0.046 0.2906 0.2906
0.0417 0.3906 0.3906
0.0149 0.4092 1
0.0457 0.3119 0.4111
0.1176 0.2988 0.2988
0.0264 1 1
0.0407 0.3898 0.3898
0.0448 0.5251 1
0.0278 0.4751 1
0.0488 0.7152 0.7003
0.0239 0.2553 0.2553
0.0948 0.3435 0.9091
0.0764 0.4411 0.4679
0.0715 0.3864 0.3864
0.1975 0.524 1
0.1471 0.3727 0.3727
0.1975 0.524 1
0.1176 0.2988 0.2988
0.0263 0.4267 1
0.0227 0.7246 0.7246
0.0278 0.4995 1
0.0961 0.3665 1
0.0969 0.3157 0.3157
0.0244 0.2853 1
0.0397 0.3846 0.3839
0.0947 0.5187 1
0.0404 0.3931 0.3931
0.1176 0.2988 0.2988
0.1894 0.2641 0.4504
0.0269 0.2664 0.2664
0.0699 0.2896 0.2565
0.0392 0.4474 0.4474
0.0225 0.2716 0.2716
0.1198 0.3729 0.3729
0.0411 0.5071 0.5255
0.0235 0.3155 0.3155

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EmuJ_000907400 (Echinococcus multilocularis), peptidyl glycine alpha amidating monooxygenase
Title for this comment
Comment