Detailed view for EmuJ_000968800

Basic information

TDR Targets ID: 958170
Echinococcus multilocularis, sortilin
Source Database / ID:  GeneDB

pI: 6.6982 | Length (AA): 831 | MW (Da): 92772 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF15901   Sortilin, neurotensin receptor 3, C-terminal
PF15902   Sortilin, neurotensin receptor 3,

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  

Metabolic Pathways

Lysosome (KEGG)
Neurotrophin signaling pathway (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
43 669 5nmt (A) 189 696 37.00 0 1 0.873513 0.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128036)

Species Accession Gene Product
Babesia bovis BBOV_I002730   sortilin, putative
Candida albicans CaO19.3767   receptor for sorting of vacuolar proteins
Candida albicans CaO19.11251   receptor for sorting of vacuolar proteins
Cryptosporidium hominis Chro.70023   sortilin
Cryptosporidium parvum cgd7_110   putative sortilin, SMART_VSP10 domain, possible signal peptide
Dictyostelium discoideum DDB_G0290081   PDZ domain-containing protein
Echinococcus granulosus EgrG_000968800   sortilin
Echinococcus multilocularis EmuJ_000968800   sortilin
Homo sapiens ENSG00000134243   sortilin 1
Homo sapiens ENSG00000137642   sortilin-related receptor, L(DLR class) A repeats containing
Mus musculus ENSMUSG00000068747   sortilin 1
Mus musculus 20660   sortilin-related receptor, LDLR class A repeats-containing
Neospora caninum NCLIV_042410   sortilin, putative
Plasmodium berghei PBANKA_1315500   sortilin, putative
Plasmodium falciparum PF3D7_1451800   sortilin
Plasmodium knowlesi PKNH_1230300   sortilin, putative
Plasmodium vivax PVX_117890   sortilin, putative
Plasmodium yoelii PY01622   putative membrane glycoprotein yil173w precursor
Saccharomyces cerevisiae YNR065C   hypothetical protein
Saccharomyces cerevisiae YJL222W   Vth2p
Saccharomyces cerevisiae YIL173W   Vth1p
Saccharomyces cerevisiae YBL017C   Pep1p
Schistosoma mansoni Smp_179360   sortilin
Schmidtea mediterranea mk4.005080.00  
Schmidtea mediterranea mk4.019627.00  
Schmidtea mediterranea mk4.000666.07   Sortilin
Toxoplasma gondii TGME49_290160   sortilin, putative
Theileria parva TP01_0016   sortilin, putative

Essentiality

EmuJ_000968800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_290160 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens sortilin 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0423 0.6401 0.6401
0.0068 0.3854 0.3831
0.0041 1 1
0.0736 0.9386 0.9386
0.1092 1 1
0.0738 0.9226 0.9226
0.0672 0.3068 0.3068
0.0073 0.4438 1
0.0438 0.4164 0.4164
0.0078 1 0.5
0.0083 1 0.5
0.0123 1 0.5
0.0067 1 1
0.1174 1 1
0.0875 0.8918 0.8918
0.0675 1 1
0.0603 0.6136 0.6134
0.1018 0.7687 1
0.0663 0.7869 0
0.0663 0.7869 0
0.0461 0.8183 1
0.00351387 1 0.5
0.0084 1 0.5
0.0773 1 1
0.0042 1 0.5
0.0475 1 0.5
0.0084 0.5316 1
0.0773 1 1
0.0076 1 0.5
0.0084 1 0.5
0.0068 0.3854 0.3831
0.0084 1 0.5
0.0112 1 0.5
0.0121 0.3433 0.338
0.0236 0.8487 0.8487
0.008 1 0.5
0.029 0.8962 0.8961
0.0932 0.8225 0.9592
0.0957 1 1
0.0753 0.3361 0.336
0.0084 0.2819 1
0.0744 0.9175 0.9175
0.0163 1 0.5
0.0068 0.3854 0.3831
0.0738 0.9226 0.9226
0.0112 0.342 0.3191
0.1145 1 1
0.0744 1 1
0.0043 1 0.5
0.0056 0.5088 0.4876
0.0822 1 0.5
0.0082 1 0.5
0.0875 0.8918 0.8918
0.0082 1 0.5
0.0908115 0.573463 0.573463
0.0887 1 0.5
0.0082 1 0.5
0.0069 0.3731 0.3731
0.0118 0.7004 0.698
0.0932 0.8225 0.9592
0.0163 1 0.5
0.057 0.2527 0.2527
0.0082 0.3329 0.3297
0.0239 1 0.5
0.0084 0.2819 1
0.0339 0.313 0.313
0.0753 0.3361 0.336
0.0069 1 1
0.0135 1 0.5
0.0738 0.9226 0.9226

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EmuJ_000968800 (Echinococcus multilocularis), sortilin
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