pI: 8.1054 |
Length (AA): 529 |
MW (Da): 58668 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 500 | 2v1x (A) | 113 | 584 | 43.00 | 0 | 1 | 1.42068 | -0.27 |
1 | 529 | 4cdg (A) | 689 | 1213 | 32.00 | 0 | 1 | 1.2805 | 0.48 |
209 | 320 | 2p6n (A) | 424 | 536 | 24.00 | 0 | 0.96 | 0.64142 | -1.24 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126644)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G10930 | ATP-dependent DNA helicase Q-like 4A |
Arabidopsis thaliana | AT1G60930 | RECQ helicase L4B |
Arabidopsis thaliana | AT3G05740 | ATP-dependent DNA helicase Q-like 1 |
Arabidopsis thaliana | AT1G31360 | mediator of RNA polymerase II transcription subunit 34 |
Arabidopsis thaliana | AT4G35740 | ATP-dependent DNA helicase Q-like 3 |
Babesia bovis | BBOV_II005510 | ATP-dependent DNA helicase, RecQ family protein |
Babesia bovis | BBOV_II000810 | ATP-dependent DNA helicase, RecQ family protein |
Brugia malayi | Bm1_34870 | ATP-dependent DNA helicase, RecQ family protein |
Brugia malayi | Bm1_04100 | ATP-dependent DNA helicase, RecQ family protein |
Brugia malayi | Bm1_49360 | Bloom's syndrome protein homolog |
Candida albicans | CaO19.5335 | DNA helicase |
Candida albicans | CaO19.12795 | DNA helicase |
Caenorhabditis elegans | CELE_F18C5.2 | Protein WRN-1 |
Caenorhabditis elegans | CELE_K02F3.12 | Protein K02F3.12, isoform B |
Caenorhabditis elegans | CELE_T04A11.6 | Protein HIM-6 |
Caenorhabditis elegans | CELE_E03A3.2 | Protein RCQ-5 |
Cryptosporidium hominis | Chro.60507 | DEAD/DEAH box helicase |
Cryptosporidium parvum | cgd6_4420 | RecQ bloom helicase (RNA helicase+hrdc) |
Dictyostelium discoideum | DDB_G0268512 | ATP-dependent DNA helicase RecQ family protein |
Dictyostelium discoideum | DDB_G0292130 | ATP-dependent DNA helicase RecQ family protein |
Dictyostelium discoideum | DDB_G0272384 | ATP-dependent DNA helicase RecQ family protein |
Drosophila melanogaster | Dmel_CG6920 | Bloom syndrome helicase ortholog |
Drosophila melanogaster | Dmel_CG4879 | homolog of RecQ |
Escherichia coli | b3822 | ATP-dependent DNA helicase |
Echinococcus granulosus | EgrG_001047300 | bloom syndrome protein |
Echinococcus granulosus | EgrG_000859600 | ATP dependent DNA helicase Q1 |
Echinococcus granulosus | EgrG_001072500 | ATP dependent DNA helicase Q5 |
Entamoeba histolytica | EHI_028890 | recQ family helicase, putative |
Entamoeba histolytica | EHI_023090 | recQ family DNA helicase |
Echinococcus multilocularis | EmuJ_001072500 | ATP dependent DNA helicase Q5 |
Echinococcus multilocularis | EmuJ_000859600 | ATP dependent DNA helicase Q1 |
Echinococcus multilocularis | EmuJ_001047300 | bloom syndrome protein |
Giardia lamblia | GL50803_9266 | Sgs1 DNA helicase, putative |
Homo sapiens | ENSG00000165392 | Werner syndrome, RecQ helicase-like |
Homo sapiens | ENSG00000004700 | RecQ helicase-like |
Homo sapiens | ENSG00000108469 | RecQ protein-like 5 |
Homo sapiens | ENSG00000197299 | Bloom syndrome, RecQ helicase-like |
Leishmania braziliensis | LbrM.24.1330 | ATP-dependent DEAD/H DNA helicase recQ, putative |
Leishmania donovani | LdBPK_241590.1 | ATP-dependent DEAD/H DNA helicase recQ, putative |
Leishmania infantum | LinJ.24.1590 | ATP-dependent DEAD/H DNA helicase recQ, putative |
Leishmania major | LmjF.24.1530 | ATP-dependent DEAD/H DNA helicase recQ, putative |
Leishmania mexicana | LmxM.24.1530 | ATP-dependent DEAD/H DNA helicase recQ, putative |
Loa Loa (eye worm) | LOAG_11266 | RecQ helicase |
Loa Loa (eye worm) | LOAG_11609 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11097 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00580 | ATP-dependent DNA helicase |
Loa Loa (eye worm) | LOAG_00711 | hypothetical protein |
Mus musculus | ENSMUSG00000030528 | Bloom syndrome, RecQ helicase-like |
Mus musculus | ENSMUSG00000030243 | RecQ protein-like |
Mus musculus | ENSMUSG00000031583 | Werner syndrome homolog (human) |
Mus musculus | ENSMUSG00000020752 | RecQ protein-like 5 |
Neospora caninum | NCLIV_058800 | hypothetical protein |
Neospora caninum | NCLIV_040350 | hypothetical protein |
Oryza sativa | 4344306 | Os07g0681600 |
Oryza sativa | 4351098 | Os11g0672700 |
Oryza sativa | 4330923 | Os02g0780800 |
Oryza sativa | 4351234 | Os11g0708600 |
Plasmodium berghei | PBANKA_1014800 | ADP-dependent DNA helicase RecQ, putative |
Plasmodium berghei | PBANKA_0819500 | ATP-dependent DNA helicase Q1, putative |
Plasmodium falciparum | PF3D7_1429900 | ADP-dependent DNA helicase RecQ |
Plasmodium falciparum | PF3D7_0918600 | ATP-dependent DNA helicase Q1 |
Plasmodium knowlesi | PKNH_1328800 | ADP-dependent DNA helicase RecQ, putative |
Plasmodium knowlesi | PKNH_0716600 | ATP-dependent DNA helicase Q1, putative |
Plasmodium vivax | PVX_085045 | ADP-dependent DNA helicase RecQ, putative |
Plasmodium yoelii | PY07206 | ATP-dependent DNA helicase-related |
Plasmodium yoelii | PY01271 | ATP-dependent DNA helicase recQ-related |
Saccharomyces cerevisiae | YMR190C | Sgs1p |
Schistosoma japonicum | Sjp_0003760 | ko:K03654 ATP-dependent DNA helicase RecQ, putative |
Schistosoma japonicum | Sjp_0132250 | Bloom syndrome protein homolog, putative |
Schistosoma mansoni | Smp_056620 | DNA helicase recq1 |
Schistosoma mansoni | Smp_178900 | blooms syndrome DNA helicase |
Schistosoma mansoni | Smp_129130 | DNA helicase recq5 |
Schmidtea mediterranea | mk4.005162.00 | Werner Syndrome-like exonuclease |
Schmidtea mediterranea | mk4.001282.07 | Werner Syndrome-like exonuclease |
Schmidtea mediterranea | mk4.002999.00 | Bloom syndrome protein |
Schmidtea mediterranea | mk4.000882.02 | |
Schmidtea mediterranea | mk4.001595.06 | Bloom syndrome protein |
Schmidtea mediterranea | mk4.000541.10 | |
Schmidtea mediterranea | mk4.000882.03 | Putative ATP-dependent DNA helicase Q1 |
Schmidtea mediterranea | mk4.000009.09 | Putative dna helicase recq5 |
Schmidtea mediterranea | mk4.038149.00 | Bloom syndrome protein homolog |
Trypanosoma brucei gambiense | Tbg972.8.6870 | ATP-dependent DEAD/H DNA helicase recQ, putative |
Trypanosoma brucei | Tb927.8.6690 | ATP-dependent DEAD/H DNA helicase recQ, putative |
Trypanosoma cruzi | TcCLB.507989.40 | ATP-dependent DEAD/H DNA helicase recQ, putative |
Trypanosoma cruzi | TcCLB.510063.20 | ATP-dependent DEAD/H DNA helicase recQ, putative |
Trypanosoma cruzi | TcCLB.509243.60 | ATP-dependent DEAD/H DNA helicase recQ, putative |
Toxoplasma gondii | TGME49_316300 | ATP-dependent DNA helicase, RecQ family protein |
Toxoplasma gondii | TGME49_259250 | ATP-dependent DNA helicase, RecQ family protein |
Toxoplasma gondii | TGME49_264840 | ATP-dependent DNA helicase, RecQ family protein |
Treponema pallidum | TP0103 | ATP-dependent DNA helicase |
Theileria parva | TP04_0501 | hypothetical protein |
Theileria parva | TP02_0509 | DNA helicase, putative |
Trichomonas vaginalis | TVAG_233770 | DNA helicase recq, putative |
Trichomonas vaginalis | TVAG_255850 | DNA helicase recq, putative |
Trichomonas vaginalis | TVAG_486790 | DNA helicase recq1, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.6690 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.6690 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.6690 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.6690 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3822 | Escherichia coli | non-essential | goodall |
CELE_F18C5.2 | Caenorhabditis elegans | larval arrest | wormbase |
PBANKA_0819500 | Plasmodium berghei | Dispensable | plasmo |
PBANKA_1014800 | Plasmodium berghei | Slow | plasmo |
TGME49_264840 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_316300 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_259250 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_264840 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_316300 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_259250 | Toxoplasma gondii | Probably non-essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | Werner syndrome, RecQ helicase-like | Compounds | References |
Homo sapiens | RecQ helicase-like | Compounds | References |
Homo sapiens | Bloom syndrome, RecQ helicase-like | Compounds | References |