Detailed view for EmuJ_000809800

Basic information

TDR Targets ID: 958872
Echinococcus multilocularis, eukaryotic translation initiation factor 4E
Source Database / ID:  GeneDB

pI: 4.4101 | Length (AA): 194 | MW (Da): 22884 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01652   Eukaryotic initiation factor 4E

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0003743   translation initiation factor activity  
GO:0003723   RNA binding  
GO:0006413   translational initiation  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 194 2gpq (A) 22 217 31.00 0 1 1.37609 -0.35
14 194 3hxi (A) 23 203 51.00 0 1 1.73239 -2.08

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127278)

Species Accession Gene Product
Arabidopsis thaliana AT1G29550   translation initiation factor eIF-4E
Arabidopsis thaliana AT5G35620   translation initiation factor 4E-2
Arabidopsis thaliana AT4G18040   translation initiation factor eIF-4E
Arabidopsis thaliana AT1G29590   translation initiation factor eIF-4E
Brugia malayi Bm1_51510   translation initiation factor 4E
Candida albicans CaO19.7626   mRNA cap-binding protein eIF4E, translation initiation
Caenorhabditis elegans CELE_B0348.6   Protein IFE-3, isoform A
Cryptosporidium hominis Chro.60132   initiation factor e4
Cryptosporidium parvum cgd6_1020   translation initiation factor if-4E
Dictyostelium discoideum DDB_G0268574   eukaryotic translation initiation factor 4E
Drosophila melanogaster Dmel_CG4035   Eukaryotic initiation factor 4E
Drosophila melanogaster Dmel_CG10124   CG10124 gene product from transcript CG10124-RA
Drosophila melanogaster Dmel_CG8023   eukaryotic translation initiation factor 4E-3
Drosophila melanogaster Dmel_CG8277   CG8277 gene product from transcript CG8277-RA
Drosophila melanogaster Dmel_CG32859   CG32859 gene product from transcript CG32859-RA
Echinococcus granulosus EgrG_000809800   eukaryotic translation initiation factor 4E
Entamoeba histolytica EHI_159690   eukaryotic translation initiation factor 4E, putative
Entamoeba histolytica EHI_180000   eukaryotic translation initiation factor 4E, putative
Echinococcus multilocularis EmuJ_000809800   eukaryotic translation initiation factor 4E
Homo sapiens 1977   eukaryotic translation initiation factor 4E
Homo sapiens ENSG00000175766   eukaryotic translation initiation factor 4E family member 1B
Leishmania braziliensis LbrM.27.1750   eukaryotic translation initiation factor eIF-4E, putative
Leishmania donovani LdBPK_191520.1   Eukaryotic translation initiation factor 4E-2
Leishmania donovani LdBPK_271520.1   Eukaryotic translation initiation factor 4E-1
Leishmania infantum LinJ.19.1520   eukaryotic translation initiation factor-like protein
Leishmania infantum LinJ.27.1520   eukaryotic translation initiation factor eIF-4E, putative
Leishmania major LmjF.19.1500   eukaryotic translation initiation factor-like
Leishmania major LmjF.19.1480   eukaryotic translation initiation factor-like protein
Leishmania major LmjF.27.1620   eukaryotic translation initiation factor eIF-4E, putative
Leishmania mexicana LmxM.27.1620   eukaryotic translation initiation factor eIF-4E, putative
Leishmania mexicana LmxM.19.1480   eukaryotic translation initiation factor-like protein
Loa Loa (eye worm) LOAG_00067   translation initiation factor 4E
Mus musculus ENSMUSG00000074895   eukaryotic translation initiation factor 4E family member 1B
Mus musculus ENSMUSG00000028156   eukaryotic translation initiation factor 4E
Neospora caninum NCLIV_049030   hypothetical protein
Oryza sativa 4348852   Os10g0467600
Saccharomyces cerevisiae YOL139C   translation initiation factor eIF4E
Schistosoma japonicum Sjp_0071720   ko:K03259 translation initiation factor eIF-4E, putative
Schistosoma mansoni Smp_001500   eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.030686.01   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.032669.00   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.000563.03   eIF4E1-like protein
Schmidtea mediterranea mk4.010954.00   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.000393.09   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.006186.00   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.003814.02  
Schmidtea mediterranea mk4.030219.00   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.017395.00  
Schmidtea mediterranea mk4.000243.10   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.007205.04   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.015450.00   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.000880.02   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.025337.00  
Schmidtea mediterranea mk4.010772.05   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.004845.01   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.000393.10  
Schmidtea mediterranea mk4.010772.02   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.006062.03   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.004070.01   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.013398.01   Putative eukaryotic translation initiation factor 4e
Schmidtea mediterranea mk4.004029.02   Putative eukaryotic translation initiation factor 4e
Trypanosoma brucei gambiense Tbg972.11.2510   eukaryotic translation initiation factor 4e, putative
Trypanosoma brucei Tb927.11.2260   Eukaryotic translation initiation factor 4E-1
Trypanosoma congolense TcIL3000_0_07850   Eukaryotic translation initiation factor 4E-1
Trypanosoma cruzi TcCLB.503593.10   Eukaryotic translation initiation factor 4E-1
Trypanosoma cruzi TcCLB.506127.170   Eukaryotic translation initiation factor 4E-1
Toxoplasma gondii TGME49_223410   eukaryotic initiation factor-4E, putative
Theileria parva TP02_0735   translation initiation factor E4, putative
Trichomonas vaginalis TVAG_479590   eukaryotic translation initiation factor 4E, putative
Trichomonas vaginalis TVAG_379750   eukaryotic translation initiation factor 4E, putative
Trichomonas vaginalis TVAG_553430   eukaryotic translation initiation factor 4E, putative
Trichomonas vaginalis TVAG_074020   eukaryotic translation initiation factor 4E, putative

Essentiality

EmuJ_000809800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.18.0004 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.18.0004 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.18.0004 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.18.0004 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_B0348.6 Caenorhabditis elegans embryonic lethal wormbase
YOL139C Saccharomyces cerevisiae inviable yeastgenome
TGME49_223410 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Oryctolagus cuniculus Eukaryotic translation initiation factor 4E Compounds References
Homo sapiens eukaryotic translation initiation factor 4E Compounds References
Mus musculus eukaryotic translation initiation factor 4E Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0011 1 1
0.2432 1 1
0.0379 0.2524 0.9989
0.1182 0.7453 0.7453
0.0591 0.3084 0.3079
0.1705 1 1
0.0042 1 1
0.0042 0.5 0.5
0.0042 0.5 0.5
0.0425 0.2593 1
0.1403 0.9172 1
0.1266 0.9682 1
0.0138 0.5489 0.5489
0.1241 0.3726 0.3726
0.0995 0.3077 1
0.1722 1 1
0.1787 0.5 0.5
0.0464 1 1
0.0702 0.3425 0
0.0042 1 1
0.0319 0.3469 0.3659
0.1111 0.3873 0.3873
0.0621 1 1
0.1218 0.2933 0.2933
0.021 0.2707 0.2687
0.129 0.4726 0.4726
0.0042 0.5 0.5
0.138 0.8871 1
0.0693 0.4634 0.7644
0.0042 0.5 0.5
0.0068 0.3457 1
0.1292 0.9571 1
0.0919 0.6726 0.6957
0.1048 0.6823 0.6823
0.1111 0.3873 0.3873
0.0997 1 1
0.0919 0.6726 0.6957
0.00309928 1 0.5
0.0813 0.6956 0.6956
0.0742 1 1
0.1621 0.3968 1
0.0083 0.5 0.5
0.0289 0.7111 0.7082
0.0072 0.4256 0.4256
0.1107 0.7339 1
0.0864 0.5779 1
0.0042 1 1
0.0068 0.3407 0.3293
0.0584 0.3263 0.3636
0.0042 1 1
0.0042 0.5 0.5
0.1355 1 1
0.0042 0.5 0.5
0.0042 0.5 0.5
0.1971 1 1
0.0458 1 1
0.082 0.5429 1
0.0376 0.5359 0.5359
0.1039 0.6912 1
0.1971 1 1
0.0684 1 1
0.0694 0.4648 1
0.0112 0.458 1
0.0694 0.4648 1
0.0169 0.4173 1
0.0275 0.3238 0.3238
0.0042 1 1
0.0042 1 1
0.1044 0.702 1
0.0042 0.2714 0.2517
0.1438 1 1
0.1129 0.8586 1
0.0042 0.5 0.5
0.1216 0.376 0.7705
0.1012 1 1
0.0083 0.5 0.5
0.1103 0.8651 1
0.0112 0.458 1
0.1461 1 0.5
0.0042 0.5 0.5
0.0042 0.5 0.5
0.0516 0.3809 1
0.0401 0.2571 1
0.0042 0.5 0.5
0.1169 0.7772 1
0.1008 0.682 1
0.021 0.2707 0.2687
0.0042 1 1
0.2172 1 1
0.0584 0.3263 0.3636
0.0042 1 1
0.1111 0.3873 0.3873
0.0144 0.4387 1
0.0319 0.3469 0.3659
0.1111 0.3873 0.3873
0.0042 0.5 0.5
0.01 1 1
0.0042 0.5 0.5
0.0042 0.5 0.5
0.0042 0.5 0.5
0.0988 1 1
0.0777 0.609 0.7427
0.056 0.5447 0.3955
0.1328 0.9886 1
0.0742 1 1
0.0618 0.3876 0.3871
0.0919 0.2944 0.673
0.0702 1 1
0.0214 0.2645 0.1894
0.1 0.7832 1
0.0864 0.5779 1
0.0104 0.3623 0.4886
0.0042 0.5 0.5
0.0966 0.631 0.683
0.0770213 0.87971 1
0.0464 1 1
0.0958 1 1
0.0584 0.3263 0.3636
0.0042 0.5 0.5
0.1072 0.7019 1
0.0042 0.5 0.5
0.1111 0.3873 0.3873
0.196 0.3431 0.3431
0.0721 0.477 0.9033
0.0968 0.7585 0.9881
0.0042 1 1
0.0042 0.5 0.5
0.1041 0.67 1
0.0214 0.2645 0.1894
0.1072 0.6944 1
0.1271 1 1
0.0042 0.5 0.5
0.0042 0.5 0.5
0.0203 1 1
0.0319 0.3469 0.3659
0.1109 0.7459 1
0.0402 0.2522 1
0.0194 0.2869 0.2869
0.1111 0.3873 0.3873
0.0042 0.5 0.5
0.1343 1 1
0.0416 0.2567 0.2996
0.0464 1 1
0.0042 0.5 0.5
0.0042 0.5 0.5
0.056 0.5447 0.3955
0.0515 0.3429 0.7469
0.056 0.5447 0.3955
0.0955 0.683 0.683
0.0112 0.4691 0.6614
0.0112 0.4691 0.6614
0.1396 0.7012 0.7012
0.0863 0.5795 1
0.1066 1 0.5
0.0068 0.5568 0.5568
0.0275 0.3238 0.3238
0.0143 0.28 0.2759
0.1749 1 1
0.0042 0.5 0.5
0.1111 0.3873 0.3873
0.0042 0.5 0.5
0.1052 0.6699 1
0.0595 0.348 1
0.0083 0.5 0.5
0.0464 1 1
0.1111 0.3873 0.3873
0.0994 0.7778 1
0.0042 0.5 0.5
0.0149 0.4473 1
0.129 0.4726 0.4726
0.0275 0.3238 0.3238
0.1039 0.6912 1
0.1601 0.5 0.5
0.1307 0.9777 1
0.0083 0.5 0.5
0.0233 0.5223 0.5223
0.0042 0.5 0.5
0.1132 0.8445 1
0.0042 0.5 0.5
0.1109 0.7145 1
0.1111 0.3873 0.3873
0.0448 0.2666 1
0.1111 0.3873 0.3873
0.0042 0.5 0.5
0.1403 0.9172 1
0.0239 1 1
0.0955 0.6829 0.6826
0.1074 0.7363 1
0.1239 0.9388 1
0.0083 0.5 0.5
0.1218 0.2933 0.2933
0.0961 0.6282 1
0.1039 0.6912 1
0.196 0.3431 0.3431
0.0068 0.347 0.3709
0.0042 0.5 0.5
0.1621 0.3968 1
0.0042 0.5 0.5
0.0169 0.4097 0.4035
0.0923 1 1
0.1085 0.7391 1
0.0969 0.6587 1
0.0448 0.2666 1
0.0042 0.5 0.5
0.0447 0.2745 1
0.0169 1 1
0.0962 0.7351 1
0.1115 0.7137 1
0.1072 0.6944 1
0.0288 0.7807 0.7806
0.0710837 0.5 0.5
0.0621 0.4875 1
0.0578 0.2717 0.2717
0.0584 0.3263 0.3636
0.0323 0.3116 0.3116
0.0042 1 1
0.0319 0.3469 0.3659
0.0042 0.5 0.5
0.0821 0.5055 1
0.0638 0.645 0.645
0.1621 0.3968 1
0.0295 0.6607 0.6607
0.0618 0.3876 0.3871
0.0042 0.5 0.5
0.0042 0.5 0.5
0.0549 0.6196 0.619
0.014 1 1
0.1343 1 1
0.0042 1 1
0.0584 0.3263 0.3636
0.0722 0.4798 1
0.1043 0.8277 1
0.0886 0.6901 1
0.0331 1 1
0.1039 0.6912 1
0.064 1 1
0.0964 0.6347 1
0.0458 1 1
0.1048 0.6823 0.6823
0.0204 1 1
0.0693 0.4634 0.7644
0.1719 1 1
0.1115 0.7137 1
0.1252 0.8013 1
0.0453 1 1
0.06 0.2772 0.2772
0.0042 0.5858 0.5858
0.1269 1 1
0.1417 0.9164 1
0.024 0.7937 0.9676
0.0345 1 1
0.0464 1 1
0.0042 0.5 0.5
0.0042 0.9245 0.9245
0.0433 0.2561 1
0.0042 1 1
0.0864 0.6702 1
0.0289 0.7608 0.733
0.0864 0.6702 1
0.1132 0.8445 1
0.0068 0.3407 0.3293
0.0068 0.3407 0.3293
0.1155 1 1
0.0042 0.5 0.5
0.0067 0.7142 0.7142
0.1319 0.9876 1
0.0042 0.5 0.5
0.1043 0.8277 1
0.0621 0.4875 1
0.0326 1 1
0.1111 0.3873 0.3873
0.1162 0.7832 1
0.1244 0.819 1
0.1147 1 1
0.1241 0.3726 0.3726
0.014 1 1
0.0517 0.3121 0.4999
0.0822 0.6331 1
0.1089 0.6905 1
0.143 0.9146 1
0.0068 0.6683 0.6683

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EmuJ_000809800 (Echinococcus multilocularis), eukaryotic translation initiation factor 4E
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