Detailed view for EmuJ_000801700

Basic information

TDR Targets ID: 958905
Echinococcus multilocularis, cytidine and deoxycytidylate deaminase
Source Database / ID:  GeneDB

pI: 7.1841 | Length (AA): 437 | MW (Da): 48744 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00383   Cytidine and deoxycytidylate deaminase zinc-binding region

Gene Ontology

Mouse over links to read term descriptions.
GO:0046872   metal ion binding  
GO:0003824   catalytic activity  
GO:0030001   metal ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 67 2roe (A) 4 66 21.00 0 1 0.53393 -1.4
270 429 1z3a (A) 18 141 32.00 0 1 0.458033 0.19
271 427 3ocq (A) 19 139 35.00 0.00039 0.58 0.398768 0.7
271 408 1wkq (A) 3 105 31.00 0 0.91 0.320689 0.37
311 412 5xkr (A) 4 112 18.00 0.03 0.07 0.36681 -0.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129418)

Species Accession Gene Product
Arabidopsis thaliana AT5G24670   tRNA adenosine deaminase 3
Babesia bovis BBOV_IV001990   conserved hypothetical protein
Brugia malayi Bm1_21975   Cytidine and deoxycytidylate deaminase zinc-binding region family protein
Candida albicans CaO19.5090   similar to S. cerevisiae TAD3 (YLR316C) subunit of adenosine deaminase that converts the tRNA wobble position to insosine
Candida albicans CaO19.12556   similar to S. cerevisiae TAD3 (YLR316C) subunit of adenosine deaminase that converts the tRNA wobble position to insosine
Caenorhabditis elegans CELE_Y47D3A.14   Protein Y47D3A.14
Cryptosporidium hominis Chro.70174   hypothetical protein
Cryptosporidium parvum cgd7_1470   hypothetical protein
Dictyostelium discoideum DDB_G0278841   cytidine deaminase-like protein
Drosophila melanogaster Dmel_CG10927   CG10927 gene product from transcript CG10927-RA
Echinococcus granulosus EgrG_000801700   cytidine and deoxycytidylate deaminase
Echinococcus granulosus EgrG_000801800   tRNA specific adenosine deaminase protein
Entamoeba histolytica EHI_019970   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000801800   tRNA specific adenosine deaminase protein
Echinococcus multilocularis EmuJ_000801700   cytidine and deoxycytidylate deaminase
Homo sapiens ENSG00000213638   adenosine deaminase, tRNA-specific 3
Loa Loa (eye worm) LOAG_07276   hypothetical protein
Mus musculus ENSMUSG00000035370   adenosine deaminase, tRNA-specific 3
Oryza sativa 4346442   Os09g0128600
Onchocerca volvulus OVOC7755  
Plasmodium berghei PBANKA_0603500   cytidine deaminase, putative
Plasmodium falciparum PF3D7_1204600   cytidine deaminase, putative
Plasmodium knowlesi PKNH_1304300   cytidine deaminase, putative
Plasmodium vivax PVX_084270   cytidine deaminase, putative
Plasmodium yoelii PY04717   Cytidine and deoxycytidylate deaminase zinc-binding region, putative
Saccharomyces cerevisiae YLR316C   Tad3p
Schistosoma japonicum Sjp_0009940   tRNA-specific adenosine deaminase subunit tad3, putative
Schistosoma japonicum Sjp_0009950   expressed protein
Schistosoma mansoni Smp_146030   dCTP deaminase
Schmidtea mediterranea mk4.012023.01  
Schmidtea mediterranea mk4.010519.02  
Theileria parva TP03_0456   hypothetical protein, conserved

Essentiality

EmuJ_000801700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YLR316C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0603500 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EmuJ_000801700 (Echinococcus multilocularis), cytidine and deoxycytidylate deaminase
Title for this comment
Comment