Detailed view for EmuJ_000485500

Basic information

TDR Targets ID: 958928
Echinococcus multilocularis, serine protein kinase ATM

Source Database / ID:  GeneDB

pI: 6.6688 | Length (AA): 3636 | MW (Da): 406486 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00454   Phosphatidylinositol 3- and 4-kinase
PF02260   FATC domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016301   kinase activity  
GO:0005515   protein binding  

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
207 246 2jss (B) 4 43 17.00 0 0.01 0.256501 -0.93
633 1445 4xrk (A) 45 813 12.00 0 0.8 0.273097 0.56
1297 1996 3ibv (B) 46 779 10.00 0 0.96 0.229019 0.7
1829 2057 4d4e (A) 12 246 11.00 0.35 0.27 0.162481 -0.52
1918 2101 5mfi (A) 13 206 11.00 0.24 0.17 0.156105 -0.68
2461 2593 2fo7 (A) 1 136 11.00 0.81 0.03 0.111079 -0.11
2942 3507 3ls8 (B) 346 837 23.00 0 1 -0.00783443 1.05
3229 3632 5wby (B) 2172 2545 34.00 0 1 0.175711 0.65
3235 3501 5luq (A) 3744 4013 35.00 0 1 0.311032 0.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128955)

Species Accession Gene Product
Arabidopsis thaliana AT3G48190   serine/threonine-protein kinase ATM
Brugia malayi Bm1_40395   Phosphatidylinositol 3- and 4-kinase family protein
Candida albicans CaO19.1018   identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase
Candida albicans CaO19.5580   similar to putative phosphatidylinositol kinase involved in telomere length regulation
Candida albicans CaO19.13026   similar to putative phosphatidylinositol kinase involved in telomere length regulation
Drosophila melanogaster Dmel_CG6535   telomere fusion
Echinococcus granulosus EgrG_000485500   serine protein kinase ATM
Entamoeba histolytica EHI_017670   hypothetical protein
Echinococcus multilocularis EmuJ_000485500   serine protein kinase ATM
Homo sapiens ENSG00000149311   ATM serine/threonine kinase
Leishmania braziliensis LbrM.02.0130   phosphatidylinositol kinase related protein, putative
Leishmania donovani LdBPK_020100.1   phosphatidylinositol 3-kinase-like protein
Leishmania infantum LinJ.02.0100   phosphatidylinositol kinase related protein, putative
Leishmania major LmjF.02.0120   phosphatidylinositol kinase related protein, putative
Leishmania mexicana LmxM.02.0120   phosphatidylinositol 3-kinase-like protein
Loa Loa (eye worm) LOAG_04206   hypothetical protein
Mus musculus ENSMUSG00000034218   ataxia telangiectasia mutated
Neospora caninum NCLIV_064490   phosphatidylinositol 3- and 4-kinase domain- containing protein, putative
Oryza sativa 4326151   Os01g0106700
Saccharomyces cerevisiae YBL088C   Tel1p
Schistosoma japonicum Sjp_0026270   hypothetical protein
Schistosoma japonicum Sjp_0308010   IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing
Schistosoma japonicum Sjp_0065320   ko:K04728 ataxia telangectasia mutated family protein, putative
Schistosoma japonicum Sjp_0108830   hypothetical protein
Schistosoma mansoni Smp_157820   ataxia telangiectasia mutated (atm)
Schmidtea mediterranea mk4.002177.01   Serine/threonine-protein kinase ATM
Schmidtea mediterranea mk4.002177.02   Serine-protein kinase ATM
Trypanosoma brucei gambiense Tbg.972.2.840   phosphatidylinositol kinase domain protein, putative
Trypanosoma brucei Tb927.2.2260   phosphatidylinositol kinase related protein, putative
Trypanosoma cruzi TcCLB.506533.34   phosphatidylinositol kinase related protein, putative
Trypanosoma cruzi TcCLB.509395.20   phosphatidylinositol kinase related protein, putative
Trypanosoma cruzi TcCLB.410961.10   phosphatidylinositol kinase related protein, putative
Toxoplasma gondii TGME49_248530   FATC domain-containing protein
Trichomonas vaginalis TVAG_139170   PIKK family atypical protein kinase

Essentiality

EmuJ_000485500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.2260 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.2260 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.2260 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.2260 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_248530 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ATM serine/threonine kinase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0025 0.2595 0.1584
0.003 0.4119 0.4119
0.0022 0.273 0.1584
0.003 0.4119 0.4119
0.003 0.3209 0.3209
0.0025 0.294 0.3264
0.0026 1 1
0.003 1 1
0.0028 0.392 0.2443
0.003 0.2661 1
0.003 0.4119 0.4119
0.003 1 1
0.0025 0.5761 0.5761
0.003 0.4421 1
0.003 0.5322 0.5256
0.003 0.3209 0.3209
0.0025 0.2656 0.302
0.003 0.2661 0.4488
0.003 0.5761 0.5761
0.0024 0.5761 0.5761
0.0028 0.5001 0.4835
0.003 1 1
0.003 0.4119 0.4119
0.0027 1 1
0.003 0.4314 1
0.003 0.5475 0.3776
0.0025 0.5755 0.5755
0.0024 0.2592 0.1493
0.003 0.2592 0.1493
0.003 0.3209 0.3209
0.003 0.5695 0.5695
0.0029 0.2661 1
0.003 1 1
0.003 0.291 0.2838
0.003 0.5476 0.5476
0.003 0.2661 1
0.003 1 1
0.0025 0.3106 0.3106
0.003 1 1
0.003 1 1
0.003 0.2661 1
0.0024 1 1
0.003 0.2661 1
0.003 0.5475 0.3776
0.003 0.2557 0.1644
0.003 1 1
0.0024 0.322 0.322
0.0024 0.3501 1
0.003 0.4409 0.4255
0.003 0.5557 0.4965
0.003 1 1
0.0027 0.5475 0.3776
0.003 0.337 0.4319
0.0024 0.3834 0.3834
0.003 0.5475 0.3776
0.0022 0.273 0.1584
0.003 0.527 0.4944
0.003 0.392 0.2443
0.0027 0.7976 0.6639
0.003 0.2898 0.2898
0.0024 0.3751 0.3751
0.0022 0.273 0.1584
0.003 0.3501 0.3026
0.003 0.5178 0.7879
0.0028 0.5761 0.5761
0.003 0.3501 1
0.003 0.273 0.2479
0.0027 0.3346 1
0.003 0.392 0.2443
0.0027 1 1
0.003 0.5511 0.5511
0.003 0.4119 0.4119
0.0024 0.3684 0.3823
0.003 0.2661 1
0.003 0.4842 0.4842
0.003 0.959 1
0.0024 0.3574 0.7634
0.0028 0.2534 0.2123
0.003 0.2592 0.1493
0.003 1 1
0.0024 1 1
0.003 0.2592 0.1493
0.003 0.4479 0.4479
0.0029 0.3437 1
0.003 0.3692 0.568
0.003 1 1
0.003 0.4479 0.4479
0.003 0.4314 1
0.0026 0.4745 0.3116
0.0027 1 1
0.0025 0.5761 0.5761
0.003 1 1
0.003 0.3692 1
0.0027 0.2744 0.2744
0.003 0.3115 0.3115
0.0027 0.959 1
0.003 0.3684 0.7923
0.003 1 1
0.0259 0.2538 0.2336
0.003 0.2661 1
0.003 1 1
0.0024 0.3648 0.7625
0.0026 0.2784 1
0.0028 1 1
0.003 0.3776 0.3776
0.003 1 1
0.0025 0.2592 0.1493

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier EmuJ_000485500 (Echinococcus multilocularis), serine protein kinase ATM
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