Detailed view for EmuJ_000862200

Basic information

TDR Targets ID: 959430
Echinococcus multilocularis, Protein son of sevenless
Source Database / ID:  GeneDB

pI: 7.295 | Length (AA): 1797 | MW (Da): 198838 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00617   RasGEF domain
PF00618   RasGEF N-terminal motif

Gene Ontology

Mouse over links to read term descriptions.
GO:0046982   protein heterodimerization activity  
GO:0005085   guanyl-nucleotide exchange factor activity  
GO:0007264   small GTPase mediated signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
82 1524 3ksy (A) 46 1032 31.00 0 1 0.518405 1.14
1238 1506 2ije (S) 1028 1259 24.00 0 1 0.282794 -0.38
1671 1723 3mp6 (A) 1191 1247 17.00 0 0.01 0.293594 -1.18
1683 1748 2kpy (A) 54 105 46.00 0.19 0.01 -0.0338721 1.21

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_176498)

Species Accession Gene Product
Echinococcus granulosus EgrG_000862200   Protein son of sevenless
Echinococcus granulosus EgrG_000109300   son of sevenless 1
Echinococcus multilocularis EmuJ_000109300   son of sevenless 1
Echinococcus multilocularis EmuJ_000862200   Protein son of sevenless
Schistosoma japonicum Sjp_0109680   IPR008937,Ras guanine nucleotide exchange factor;IPR000651,Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal,d
Schistosoma japonicum Sjp_0107360   hypothetical protein
Schistosoma japonicum Sjp_0019820   ko:K03099 son of sevenless, putative
Schistosoma japonicum Sjp_0123190   expressed protein
Schistosoma mansoni Smp_035190.1   ras GTP exchange factor son of sevenless
Schistosoma mansoni Smp_161230   ras GTP exchange factor son of sevenless
Schmidtea mediterranea mk4.000648.02  
Schmidtea mediterranea mk4.011929.00   Protein son of sevenless
Schmidtea mediterranea mk4.000648.03   Son of sevenless-1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000862200 (Echinococcus multilocularis), Protein son of sevenless
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