Detailed view for EmuJ_000554200

Basic information

TDR Targets ID: 959983
Echinococcus multilocularis, fibronectin type III domain-containing protein
Source Database / ID:  GeneDB

pI: 5.0944 | Length (AA): 263 | MW (Da): 28440 | Paralog Number: 1

Signal peptide: N | GPI Anchor: Y | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00041   Fibronectin type III domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
42 216 4bqc (B) 894 1077 23.00 0 1 0.826499 0.48
124 222 1x5f (A) 13 114 25.00 0 0.3 0.679526 -0.75
129 214 4u3h (A) 10 92 36.00 0.84 0.27 0.503696 0.08
129 204 1x5g (A) 18 90 34.00 0.073 0.9 0.688673 -0.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128592)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG17800   Down syndrome cell adhesion molecule 1
Drosophila melanogaster Dmel_CG31190   Down syndrome cell adhesion molecule 3
Drosophila melanogaster Dmel_CG42256   Down syndrome cell adhesion molecule 2
Drosophila melanogaster Dmel_CG42330   Down syndrome cell adhesion molecule 4
Echinococcus granulosus EgrG_000348200   Down syndrome cell adhesion molecule
Echinococcus multilocularis EmuJ_000348200   Down syndrome cell adhesion molecule
Echinococcus multilocularis EmuJ_000554200   fibronectin type III domain-containing protein
Homo sapiens ENSG00000171587   Down syndrome cell adhesion molecule
Homo sapiens ENSG00000177103   Down syndrome cell adhesion molecule like 1
Mus musculus ENSMUSG00000032087   Down syndrome cell adhesion molecule like 1
Mus musculus ensembl-mmu:ENSMUSG00000050272   Down syndrome cell adhesion molecule
Schistosoma japonicum Sjp_0039080   expressed protein
Schistosoma japonicum Sjp_0039070   Down syndrome cell adhesion molecule precursor, putative
Schistosoma mansoni Smp_164270   cell adhesion molecule
Schmidtea mediterranea mk4.001665.08  
Schmidtea mediterranea mk4.001665.06   Putative cell adhesion molecule

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0343 0.706 0.706
0.0312 0.5397 0
0.0084 0.6788 0.6788
0.0132 0.2972 0.2972
0.0048 0.4176 0.4167
0.0275 0.301 0.301
0.0448 0.7636 0.7636
0.0403 0.706 0.706
0.0266 0.2855 0.2844
0.0275 0.301 0.301
0.0378 0.586 0.586
0.0178 0.5983 0
0.0085 0.3268 0.2925
0.0374 0.7576 0.7576
0.0089 0.442 0.8994
0.037 0.706 0.706
0.0471 0.341 0.338
0.0129 0.3276 0.3276
0.043 0.5151 0.5151
0.0271 0.3613 0.3613
0.0488 0.3798 0.3794
0.0089 0.442 0.8994
0.0048 0.432 0.432
0.0116 0.6967 0.6967
0.022 0.257 0.2565
0.0164 0.7647 0.7647
0.0446 0.3014 0.3014
0.008 0.4641 0
0.0446 0.3014 0.3014
0.0084 0.6788 0.6788
0.017 0.2614 0.7011
0.0153 0.3082 0.2988
0.0241 0.3986 0.3986
0.0016 1 0.5
0.0446 0.3014 0.3014
0.0446 0.3014 0.3014
0.012 0.7362 0.7362
0.0009 0.5 0.5
0.0251 0.7407 0.7407
0.0223 0.4639 0.4639
0.0223 0.4639 0.4639
0.0475 0.706 0.706
0.0241 0.3619 0.3619
0.0338 0.7566 0.7382
0.0344 0.6972 0
0.0351 0.6072 0
0.0255 0.2557 0.2557
0.0275 0.301 0.301
0.0446 0.3014 0.3014
0.0446 0.3014 0.3014
0.0111 0.334 1
0.0471 0.341 0.338
0.0414 0.6115 0.6115
0.0104 0.8804 0.8611
0.0378 0.586 0.586
0.0334 0.4633 0.4633
0.0216 0.3372 0.3372
0.0461 0.2819 0.2813
0.0039 0.3299 0.3181
0.0156 0.6042 0.6042
0.0334 0.4633 0.4633
0.0336 0.3462 0.3408
0.0446 0.3014 0.3014
0.0167 0.3197 0.3087
0.0216 0.706 0.706
0.0155 0.3568 0.706
0.0261 0.3873 0.3873
0.0165 0.3513 0.3513
0.0343 0.706 0.706
0.0255 0.706 0.706
0.0374 0.7576 0.7576
0.012 0.7362 0.7362
0.0115 0.2557 0.2557
0.0075 0.4317 0.4317
0.0275 0.301 0.301
0.0142 0.2992 0.2956
0.0258 0.3891 0.387
0.0167 0.3197 0.3087
0.0275 0.301 0.301
0.0414 0.6115 0.6115
0.0446 0.3014 0.3014
0.0461 0.2819 0.2813
0.0178 0.5983 0
0.0083 1 0.5
0.0184 0.706 0.706
0.0034 0.2581 0.2581
0.0261 0.2557 0.2557
0.02 0.7068 0.706
0.0165 0.3513 0.3513
0.0251 0.7407 0.7407
0.0089 0.4623 0.4623
0.022 0.257 0.2565
0.0461 0.2819 0.2813
0.0156 0.6042 0.6042
0.0114 0.6153 0.3459
0.0255 0.706 0.706
0.0313 0.5953 0.5953
0.0461 0.2819 0.2813
0.0272 0.706 0.706

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EmuJ_000554200 (Echinococcus multilocularis), fibronectin type III domain-containing protein
Title for this comment
Comment