Detailed view for EmuJ_001029200

Basic information

TDR Targets ID: 960134
Echinococcus multilocularis, guanylate kinase
Source Database / ID:  GeneDB

pI: 6.1625 | Length (AA): 226 | MW (Da): 26089 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00625   Guanylate kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004385   guanylate kinase activity  
GO:0006163   purine nucleotide metabolic process  

Metabolic Pathways

Purine metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 223 4wsi (A) 408 674 28.00 0.0000066 1 1.27505 -0.18
25 210 2qor (A) 2 188 36.00 0 1 1.32491 -0.82
28 216 1lvg (A) 5 193 42.00 0.00000032 1 1.45158 -1.14
30 88 3nh6 (A) 619 666 50.00 0.37 1 0.576062 0.59

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126916)

Species Accession Gene Product
Arabidopsis thaliana AT3G06200   putative guanylate kinase
Arabidopsis thaliana AT2G41880   guanylate kinase 1
Arabidopsis thaliana AT3G57550   guanylate kinase
Babesia bovis BBOV_II006160   guanylate kinase, putative
Brugia malayi Bm1_09150   guanylate kinase
Candida albicans CaO19.8712   guanylate kinase
Candida albicans CaO19.1115   guanylate kinase
Caenorhabditis elegans CELE_T03F1.8   Protein GUK-1, isoform B
Cryptosporidium hominis Chro.70250   hypothetical protein
Cryptosporidium parvum cgd7_2190   putative guanylate kinase
Chlamydia trachomatis CT_030   guanylate kinase
Dictyostelium discoideum DDB_G0279001   guanylate kinase
Drosophila melanogaster Dmel_CG11811   CG11811 gene product from transcript CG11811-RA
Escherichia coli b3648   guanylate kinase
Echinococcus granulosus EgrG_001029200   guanylate kinase
Entamoeba histolytica EHI_118910   guanylate kinase, putative
Echinococcus multilocularis EmuJ_001029200   guanylate kinase
Giardia lamblia GL50803_7203   Guanylate kinase
Homo sapiens ENSG00000143774   guanylate kinase 1
Leishmania braziliensis LbrM.33.1290   guanylate kinase, putative
Leishmania donovani LdBPK_331150.1   guanylate kinase, putative
Leishmania infantum LinJ.33.1150   guanylate kinase, putative
Leishmania major LmjF.33.1090   guanylate kinase, putative
Leishmania mexicana LmxM.32.1090   guanylate kinase, putative
Loa Loa (eye worm) LOAG_09178   hypothetical protein
Mycobacterium leprae ML0541   Probable guanylate kinase Gmk (GMP kinase).
Mus musculus ENSMUSG00000020444   guanylate kinase 1
Mycobacterium tuberculosis Rv1389   Probable guanylate kinase Gmk
Mycobacterium ulcerans MUL_1788   guanylate kinase
Neospora caninum NCLIV_017730   Guanylate kinase, related
Oryza sativa 4352344   Os12g0515600
Oryza sativa 4332674   Os03g0320900
Plasmodium berghei PBANKA_0829700   guanylate kinase, putative
Plasmodium falciparum PF3D7_0928900   guanylate kinase
Plasmodium knowlesi PKNH_0727200   guanylate kinase, putative
Plasmodium vivax PVX_099895   guanylate kinase, putative
Plasmodium yoelii PY04174   guanylate kinase
Saccharomyces cerevisiae YDR454C   guanylate kinase
Schmidtea mediterranea mk4.009106.01  
Schmidtea mediterranea mk4.000593.00  
Schmidtea mediterranea mk4.000593.02  
Schmidtea mediterranea mk4.009753.00   Putative guanylate kinase
Schmidtea mediterranea mk4.086433.00   Guanylate kinase
Schmidtea mediterranea mk4.000593.04  
Schmidtea mediterranea mk4.028472.00  
Trypanosoma brucei gambiense Tbg972.10.14110   guanylate kinase, putative
Trypanosoma brucei Tb927.10.11700   guanylate kinase, putative
Trypanosoma congolense TcIL3000_10_9920   guanylate kinase, putative
Trypanosoma cruzi TcCLB.509647.70   guanylate kinase, putative
Toxoplasma gondii TGME49_242730   guanylate kinase family protein
Theileria parva TP02_0576   guanylate kinase, putative
Trichomonas vaginalis TVAG_441520   guanylate kinase, putative
Trichomonas vaginalis TVAG_344860   discs large, putative
Trichomonas vaginalis TVAG_441100   calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase, putative
Trichomonas vaginalis TVAG_247110   sap-102, putative
Wolbachia endosymbiont of Brugia malayi Wbm0580   guanylate kinase

Essentiality

EmuJ_001029200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.11700 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.11700 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.11700 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.10.11700 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
b3648 Escherichia coli essential goodall
CELE_T03F1.8 Caenorhabditis elegans slow growth wormbase
YDR454C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0829700 Plasmodium berghei Slow plasmo
TGME49_242730 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier EmuJ_001029200 (Echinococcus multilocularis), guanylate kinase
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