Detailed view for EmuJ_000633200

Basic information

TDR Targets ID: 960189
Echinococcus multilocularis, histone acetyltransferase MYST2

Source Database / ID:  GeneDB

pI: 9.1588 | Length (AA): 446 | MW (Da): 51880 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01530   Zinc finger, C2HC type
PF01853   MOZ/SAS family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016573   histone acetylation  
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005634   nucleus  
GO:0008270   zinc ion binding  
GO:0004402   histone acetyltransferase activity  
GO:0003700   transcription factor activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 65 1pxe (A) 20 61 48.00 0.043 0.31 0.287192 1.01
141 438 5j9u (E) 154 440 40.00 0 1 1.17386 -0.53
152 433 5wci (A) 177 449 44.00 0 1 1.22199 -0.97
154 429 5gk9 (A) 337 603 48.00 0 1 1.21143 -0.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_140862)

Species Accession Gene Product
Echinococcus granulosus EgrG_000633200   histone acetyltransferase MYST2
Echinococcus multilocularis EmuJ_000633200   histone acetyltransferase MYST2
Leishmania braziliensis LbrM.35.7380   acetyltransferase, putative
Leishmania donovani LdBPK_367340.1   acetyltransferase, putative
Leishmania infantum LinJ.36.7340   acetyltransferase, putative
Leishmania major LmjF.36.6990   acetyltransferase, putative
Leishmania mexicana LmxM.36.6990   acetyltransferase, putative
Schistosoma japonicum Sjp_0216520   Histone acetyltransferase MYST2, putative
Schistosoma mansoni Smp_171700   myst histone acetyltransferase
Trypanosoma brucei gambiense Tbg972.10.10120   acetyltransferase, putative
Trypanosoma brucei Tb927.10.8310   histone acetyltransferase
Trypanosoma congolense TcIL3000_10_7170   acetyltransferase, putative
Trypanosoma cruzi TcCLB.507611.290   acetyltransferase, putative
Trypanosoma cruzi TcCLB.507723.110   acetyltransferase, putative

Essentiality

EmuJ_000633200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.8310 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.8310 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.8310 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.8310 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0056 0.3996 0
0.0052 0.2849 0.2308
0.0053 0.3715 0.3715
0.0055 0.2623 0.2447
0.0055 0.2517 0.2517
0.0055 0.2517 0.2517
0.0056 0.3266 0.3141
0.0055 0.406 0.3219

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000633200 (Echinococcus multilocularis), histone acetyltransferase MYST2
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