Detailed view for EmuJ_001190200

Basic information

TDR Targets ID: 960487
Echinococcus multilocularis, phosphatidylinositol phosphate 5 kinase type III
Source Database / ID:  GeneDB

pI: 7.5535 | Length (AA): 1951 | MW (Da): 217435 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00118   TCP-1/cpn60 chaperonin family
PF01363   FYVE zinc finger
PF01504   Phosphatidylinositol-4-phosphate 5-Kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0046872   metal ion binding  
GO:0016307   phosphatidylinositol phosphate kinase activity  
GO:0005524   ATP binding  
GO:0046488   phosphatidylinositol metabolic process  

Structural information

Modbase 3D models:

There are 13 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 93 1joc (A) 1316 1405 32.00 0 0.63 0.409755 -0.13
12 93 2yqm (A) 3 76 32.00 0 0.79 0.24763 0.72
19 93 1dvp (A) 139 213 28.00 0 0.19 0.239042 0.45
24 95 1z2q (A) 4 75 39.00 0.0000000033 0.68 0.452404 0.33
30 93 3t7l (A) 739 800 40.00 0 0.91 0.485404 -0.05
452 653 4b2t (G) 110 333 27.00 0.000007 1 0.125037 1.49
529 675 1a6d (B) 201 354 29.00 0.000000014 1 0.426846 -0.11
530 654 4xcg (A) 209 340 30.00 0.0000073 0.91 0.26557 1
530 656 1a6d (A) 201 334 26.00 0.0001 1 0.366595 -0.01
892 984 1cpc (B) 20 112 31.00 0.093 0.4 0.358168 0
1578 1930 3x07 (B) 39 414 22.00 0.000000034 1 0.162033 0.81
1629 1928 2ybx (A) 85 402 26.00 0 0.95 0.147367 0.8
1674 1899 2gk9 (A) 132 416 34.00 0.000015 1 -0.048662 1.45

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128617)

Species Accession Gene Product
Arabidopsis thaliana AT3G14270   phosphatidylinositol-3P 5-kinase-like
Arabidopsis thaliana AT4G33240   1-phosphatidylinositol-3-phosphate 5-kinase FAB1A
Arabidopsis thaliana AT1G34260   putative 1-phosphatidylinositol-3-phosphate 5-kinase
Arabidopsis thaliana AT1G71010   1-phosphatidylinositol-4-phosphate 5-kinase
Brugia malayi Bm1_33360   FYVE zinc finger family protein
Brugia malayi Bm1_33365   FYVE finger-containing phosphoinositide kinase, putative
Candida albicans CaO19.1513   phosphatidylinositol 3-phosphate (PI(3)P) 5-kinase gene similar to S. cerevisiae FAB1 (YFR019W) involved in vacuole homeostasis
Candida albicans CaO19.9088   phosphatidylinositol 3-phosphate (PI(3)P) 5-kinase gene similar to S. cerevisiae FAB1 (YFR019W) involved in vacuole homeostasis
Caenorhabditis elegans CELE_VF11C1L.1   Protein PPK-3
Dictyostelium discoideum DDB_G0279149   1-phosphatidylinositol-3-phosphate 5-kinase
Drosophila melanogaster Dmel_CG6355   CG6355 gene product from transcript CG6355-RA
Echinococcus granulosus EgrG_001190200   phosphatidylinositol phosphate 5 kinase type III
Entamoeba histolytica EHI_049480   phosphoinositide kinase, putative
Echinococcus multilocularis EmuJ_001190200   phosphatidylinositol phosphate 5 kinase type III
Homo sapiens ENSG00000115020   phosphoinositide kinase, FYVE finger containing
Loa Loa (eye worm) LOAG_01842   FYVE zinc finger family protein
Loa Loa (eye worm) LOAG_01981   FYVE finger-containing phosphoinositide kinase
Mus musculus ENSMUSG00000025949   phosphoinositide kinase, FYVE finger containing
Oryza sativa 4345725   Os08g0450800
Oryza sativa 4333051   Os03g0399500
Oryza sativa 4337509   Os04g0691900
Oryza sativa 4344440   Os08g0104700
Oryza sativa 9269751   Os12g0236700
Oryza sativa 4346598   Os09g0278300
Oryza sativa 4340685   Os06g0259000
Oryza sativa 4345628   Os08g0428900
Oryza sativa 4345724   Os08g0450700
Saccharomyces cerevisiae YFR019W   1-phosphatidylinositol-3-phosphate 5-kinase
Schistosoma mansoni Smp_156710   phosphatidylinositol-4-phosphate-5-kinaseputativ e
Schmidtea mediterranea mk4.006045.01  
Schmidtea mediterranea mk4.006045.00  
Schmidtea mediterranea mk4.001526.00   1-phosphatidylinositol 3-phosphate 5-kinase
Theileria parva TP02_0054   hypothetical protein
Trichomonas vaginalis TVAG_456620   phosphatidylinositol-4-phosphate 5-kinase type II, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus phosphoinositide kinase, FYVE finger containing Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_001190200 (Echinococcus multilocularis), phosphatidylinositol phosphate 5 kinase type III
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