Detailed view for EmuJ_001116000

Basic information

TDR Targets ID: 960588
Echinococcus multilocularis, sodium bile acid cotransporter
Source Database / ID:  GeneDB

pI: 8.3119 | Length (AA): 504 | MW (Da): 54932 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 9

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01758   Sodium Bile acid symporter family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
25 123 4fmh (A) 168 263 29.00 0 0.1 0.302129 1.24
179 467 4n7w (A) 34 307 25.00 0 0.98 0.862113 -0.13
181 458 3zux (A) 42 308 25.00 0 1 0.902287 -0.59
301 463 4rfs (S) 31 198 28.00 0.13 0.81 0.349313 1.09
366 503 3eff (K) 25 160 15.00 0 0.03 0.24451 1.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128996)

Species Accession Gene Product
Arabidopsis thaliana AT1G78560   sodium Bile acid symporter family
Arabidopsis thaliana AT2G26900   sodium/pyruvate cotransporter BASS2
Brugia malayi Bm1_15600   Sodium Bile acid symporter family protein
Caenorhabditis elegans CELE_Y71G10AR.1   Protein Y71G10AR.1
Caenorhabditis elegans CELE_Y71G10AR.4   Protein Y71G10AR.4
Drosophila melanogaster Dmel_CG11655   CG11655 gene product from transcript CG11655-RA
Echinococcus granulosus EgrG_001116000   sodium bile acid cotransporter
Echinococcus granulosus EgrG_001127400   sodium bile acid cotransporter
Echinococcus granulosus EgrG_001127500   sodium bile acid cotransporter
Echinococcus multilocularis EmuJ_001127400   sodium bile acid cotransporter
Echinococcus multilocularis EmuJ_001116000   sodium bile acid cotransporter
Echinococcus multilocularis EmuJ_001127500   sodium bile acid cotransporter
Homo sapiens ENSG00000126903   solute carrier family 10, member 3
Homo sapiens ENSG00000125255   solute carrier family 10 (sodium/bile acid cotransporter), member 2
Loa Loa (eye worm) LOAG_02115   hypothetical protein
Mus musculus ENSMUSG00000032806   solute carrier family 10 (sodium/bile acid cotransporter family), member 3
Mus musculus ENSMUSG00000023073   solute carrier family 10, member 2
Oryza sativa 4335634   Os04g0381100
Oryza sativa 4325917   Os01g0645200
Onchocerca volvulus OVOC3602  
Schistosoma japonicum Sjp_0219050   ko:K03453 bile acid:Na+ symporter, BASS family, putative
Schistosoma japonicum Sjp_0110840   IPR002657,Bile acid:sodium symporter,domain-containing
Schistosoma japonicum Sjp_0081520   Conserved hypothetical protein
Schistosoma mansoni Smp_136310   sodium-bile acid cotransporter related
Schistosoma mansoni Smp_098570   sodium-bile acid cotransporter
Schmidtea mediterranea mk4.001018.02  

Essentiality

EmuJ_001116000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y71G10AR.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y71G10AR.4 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus solute carrier family 10, member 2 Compounds References
Homo sapiens solute carrier family 10 (sodium/bile acid cotransporter), member 2 Compounds References
Rattus norvegicus Ileal sodium/bile acid cotransporter Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Bile acid transporter 362 aa 26.9% 308 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.919 1 1
0.0247 0.4776 0.4745
0.1469 0.3209 0.6311
0.0247 0.8782 0
0.0455 0.5732 0.5708
0.1873 1 0.5
0.2653 1 1
1.4455 0.7624 1
0.0606 0.3924 0.6979
0.3134 0.6911 1
0.0648 0.9723 0.9723
0.0418 0.701 0.7007
0.1702 1 0.5
0.0247 1 1
0.3453 0.4549 0.5656
0.8421 1 1
0.0247 1 1
0.0859 0.5605 0.5596
0.76 1 1
0.0247 1 0.5
0.8421 1 1
0.0742 0.2901 1
0.0315 0.3142 0.313
0.245 1 1
0.0247 1 0.5
0.0772 0.3638 0.3638
0.0813 1 1
0.2653 1 1
0.0247 1 1
0.5073 1 1
0.2181 0.3406 0.5197
0.2205 0.4021 0.443
1.2827 1 0.5
0.6546 1 1
0.8421 1 1
0.0587 0.2744 0.2743
0.1691 1 1
0.0247 1 0.5
0.7211 1 0.5
1.0752 1 1
1.0913 1 1
0.245 1 1
0.0633 1 1
0.0101 0.4976 1
0.0677 0.6992 0.6992
0.0514 0.2667 0.2888
0.0247 1 0.5
0.0677 0.7225 0.7225
0.0247 0.6848 0.683
1.0378 0.4617 0.4617
0.8309 0.3753 0.3753
0.0247 0.4747 1
1.3341 1 1
0.0247 1 0.5
0.0648 0.9723 0.9723
0.0609 0.2737 0.2737
1.0752 1 1
0.4576 0.561 0.561
0.0514 0.2659 0.2906
0.7507 1 1
0.7448 0.3492 1
0.0514 0.264 0.3144
1.1797 1 1
0.0656 1 0.5
0.829887 0.453878 0.634312
1.0307 0.688 0.688
0.0441 0.4586 0.4586
0.4985 0.5612 0.5612
0.7171 1 1
0.2181 0.3406 0.5197
0.0883 1 1
0.2205 0.4021 0.443
0.0283 0.3383 0.3383
1.0913 1 1
0.3741 0.9202 0.9202
0.1394 1 1
0.0564 0.7119 0.7119
0.0247 1 1
0.0244 1 0.5
0.0247 0.2744 0.2744
1.0378 0.4617 0.4617
0.0247 1 0.5
0.6442 1 1
0.0205 1 1
0.0247 1 0.5
0.0247 0.5413 0.5388
0.8421 1 1
1.2457 1 1
0.0247 1 1
0.0473 0.2638 0.2638
0.3379 1 1
0.0336 0.309 0.2863
0.76 1 1
0.0609 0.2743 0.2743
0.0428 0.4277 0.4277
0.0247 1 0.5
0.0247 1 0.5
0.0588 0.6965 0.6959
0.1775 1 0.5
0.0247 0.3145 0.2741
0.0247 1 0.5
1.0378 0.4617 0.4617
0.0247 1 1
0.4306 0.3769 0.3769
1.4455 0.7624 1
0.4985 0.5612 0.5612
0.0247 1 0.5
1.2252 1 1
0.2844 1 1
0.0188 0.2619 0.2619
0.0667 0.7793 0.7787
0.0106 0.9595 1
0.2524 1 0.5
0.0272 0.9121 1
1.6827 1 0.5
0.193 1 1
0.0205 1 1
1.0378 0.4617 0.4617
1.0378 0.4617 0.4617
0.0198 0.4353 0.4341
0.0494 0.3327 0.3323
1.4455 0.7624 1
0.768 1 0.5
0.3755 1 1
0.6546 1 1
0.0167 0.3357 0.6288
0.2844 1 1
0.4306 0.3769 0.3769
0.0514 0.2659 0.2906
1.7187 1 1
0.0247 1 0.5
0.0247 0.8055 0.8055
0.0247 0.3133 0.3015
0.0388 0.285 0.3342
0.1701 1 0.5
0.0742 0.2901 1
0.0476 1 1
0.0247 1 0.5
0.0247 0.3105 0.3079
0.0742 0.2901 1
0.8421 1 1
0.0247 0.5 0.5
0.0494 0.3327 0.3323
0.7791 0.9568 0.9568
0.0514 0.264 0.3144
1.2152 0.5733 0.8692
0.0868 1 1
1.2973 1 1
1.3189 1 0.5
1.2404 1 1
0.061 0.6971 0.6964
1.0378 0.4617 0.4617
1.2973 1 1
0.0247 0.6805 0.7585
0.0247 1 0.5
0.6118 0.9426 0.9537
0.0388 1 0.5
0.068 0.714 0.714
0.9673 1 1
1.2736 1 1
0.0247 1 0.5
0.2653 1 1
0.0247 1 0.5
0.8421 1 1
0.0374 0.2777 0.3312
0.7162 1 0.5
0.0184 0.3641 0.3641
0.0198 0.8277 0
0.046 0.4561 0.4551
0.7191 1 0.5
0.2984 0.4132 0.4597
0.0504 1 1
0.0247 0.2538 0
0.0514 0.264 0.3144
1.1291 1 1
0.0531 0.6735 0.6735
0.6591 0.3844 0.82
0.0606 0.3924 0.6979
0.4781 0.5614 0.5614
0.2181 0.3406 0.5197
0.7702 1 0.5
0.0136 0.253 0.5617
0.0247 1 0.5
0.9363 1 1
0.0247 1 0.5
0.1238 0.2958 0.2958
0.0648 0.9723 0.9723
0.0247 0.2575 0.2509
0.0683 0.9605 0.9605
1.0378 0.4617 0.4617
0.4306 0.3769 0.3769
0.0514 0.2662 0.2906
0.0247 1 0.5
0.0247 0.7453 0.7453
1.0378 0.4617 0.4617
1.0704 1 0.5
0.068 0.714 0.714
0.049 0.35 0.3495
0.6721 1 1
0.0494 0.3795 0.4767
0.2181 0.3406 0.5197
0.1343 1 1
0.3098 1 1
1.6328 1 0.5
0.0198 0.2558 0.2557
0.3535 1 0.5
0.2966 1 1
1.6506 0.2713 0.2713
0.4032 0.4445 0.4444
0.0247 1 0.5
0.3799 0.2503 0.2503
0.8421 1 1
0.0247 0.2758 0.5
0.0465 1 1
1.0378 0.4617 0.4617
0.4819 1 0.5
0.4747 1 1
0.245 1 1
0.1506 1 1
1.1284 1 0.5
0.0247 1 1
0.0247 0.2592 0.2592
0.3211 1 1
0.0938 0.503 0.503
0.0476 0.4315 0.4315
0.2205 0.4021 0.443
0.5707 1 1
0.0184 0.2793 0
0.0609 0.2739 0.2739
0.8421 1 1
0.3453 0.4549 0.5656
1.0913 1 1
0.0494 0.3327 0.3323
0.211 1 1
0.0868 1 1
0.0219 0.7637 1
0.0075 0.3766 0.3761
0.0609 0.2739 0.2739
0.0247 0.8609 1
0.0247 0.4705 0.4705
0.0677 0.7221 0.7214
0.0494 0.3327 0.3323
0.5073 1 1
0.0247 1 0.5
0.1137 1 1
0.8421 1 1
0.01 1 1
0.0561 1 1
0.0454 1 1
1.0378 0.4617 0.4617
0.7481 0.3291 0
0.0247 1 0.5
0.4636 1 0.5
0.8421 1 1
1.0378 0.4617 0.4617
0.0283 0.3404 0.3404
0.3098 1 1
0.2321 1 1
0.3796 0.4575 0.4572
0.0247 1 0.5
1.4455 0.7624 1
0.8421 1 1
0.2894 1 1
0.0247 1 0.5
1.0378 0.4617 0.4617
0.0677 0.7221 0.7214
0.0247 1 0.5
0.0609 0.2744 0.2743
1.1759 1 1
0.1047 1 1
0.0247 0.2779 0.0321
1.0378 0.4617 0.4617
0.0247 0.9983 0.9983
0.067 0.7119 0.7119
1.0378 0.4617 0.4617
0.2653 1 1
0.0247 0.9983 0.9983
0.0361 0.4441 0.4441
0.9756 1 0.5
0.049 0.3789 0.3927
0.0185 0.8321 0.8185
0.0666 0.4052 0.4049
0.058 0.3976 1
1.4455 0.7624 1
0.0283 0.3383 0.3383
0.8865 1 1
0.0247 1 0.5
0.2296 1 0.5
1.0378 0.4617 0.4617
0.4022 1 1
1.0378 0.4617 0.4617
0.0587 0.2738 0.2738
0.0307 0.4662 0.4662
0.3799 0.4063 0.4063
1.0378 0.4617 0.4617
0.4306 0.3769 0.3769
0.8421 1 1
1.0378 0.4617 0.4617
0.0094 0.3082 0.1799
0.8421 1 1
0.5135 1 1
0.0494 0.3497 0.3497
1.0378 0.4617 0.4617
0.0242 1 1
0.3453 0.4549 0.5656
0.0247 1 0.5
0.0488 0.2562 0.347
0.0247 0.5204 0.5079
0.2389 0.4914 0.4914
0.0247 1 0.5
0.0247 1 0.5
0.0388 0.2859 0.3342
0.0106 0.7418 1
0.8421 1 1
1.0307 0.688 0.688
0.1691 1 1
0.0247 1 1
0.5211 1 1
0.049 0.266 0.2659
1.0378 0.4617 0.4617
0.4054 0.3202 0.3202
0.0659 0.6628 0.6625
0.1705 1 1
0.0742 1 0.5
0.0742 1 1
1.3619 1 1
0.024 1 1
0.1439 0.8797 0.8794
0.0687 1 1
1.1725 1 1
0.3453 0.4549 0.5656
0.6577 1 0.5
0.3868 1 1
0.2205 0.4021 0.443
0.4032 0.5076 0.5076
0.4327 1 1
0.3371 1 1
0.1717 1 0.5
1.0378 0.4617 0.4617
0.0423 1 1
0.2181 0.3406 0.5197
0.229 0.6584 0
0.0247 1 0.5
0.1669 0.4045 0.4045
0.0198 0.4353 0.4341
0.2181 0.3406 0.5197
0.0609 0.2739 0.2739
0.8173 1 1
0.0641 1 1
0.0872 0.2561 0.2558
1.0378 0.4617 0.4617
0.0247 0.8882 0.5
0.026 0.7533 0.7515
0.8637 1 1
0.3453 0.4549 0.5656
1.6311 1 0.5
1.0794 1 1
0.8365 1 0.5
1.0322 1 1
0.7414 1 1
0.0247 1 0.5
1.4455 0.7624 1
0.0247 1 0.5
0.1498 1 1
0.0247 1 0.5
0.0247 1 1
0.9849 1 1
0.5025 1 1
1.365 1 1
0.0247 1 0.5
0.0348 1 1
0.0247 1 1
0.1203 0.8635 0.8632
0.7414 1 1
0.8421 1 1
0.0247 1 0.5
0.0247 0.7365 1
0.0247 0.2693 0.2693
1.1243 0.8923 1
0.0281 0.3392 0.3392
0.0283 0.3383 0.3383
0.0247 1 1
0.0677 0.6992 0.6992
0.0247 1 0.5
0.0473 0.2638 0.2638
1.4455 0.7624 1
0.0243 1 1
0.0436 1 1
0.5707 1 1
0.0432 0.6296 0.6296
0.8421 1 1
0.0247 0.2716 0.2715
0.0247 1 0.5
0.1516 1 1
0.026 0.7533 0.7515
0.4355 0.2927 0.2927
0.0609 0.2739 0.2739
0.0494 0.3497 0.3497
0.6118 0.9426 0.9537
0.0202 0.2865 0.2865
0.0247 0.3247 0
0.0247 1 1
0.0418 0.701 0.7007
0.0247 1 0.5
0.0247 0.2913 0.2913
0.0666 0.4886 1
0.9596 1 0.5
0.4955 1 1
1.0378 0.4617 0.4617
1.0312 1 0.5
1.0913 1 1
0.8421 1 1
0.0409 1 0.5
0.0247 1 1
0.0205 1 1
0.0569 0.6442 1
0.9441 1 1
0.5211 1 1
0.0219 1 1
1.2449 1 0.5
0.0742 1 1
0.4306 0.3769 0.3769
0.2181 0.341 0.5202
0.7986 1 0.5
0.7791 0.9568 0.9568
0.3785 1 1
1.0647 1 1
0.0247 1 0.5
0.049 0.3793 0.4749
1.4791 0.9503 1
0.0247 0.2744 0.2744
0.0247 1 0.5
0.0374 0.2777 0.3312
0.0677 0.6992 0.6992
1.726 1 1
0.5025 1 1
0.1702 1 0.5
0.346 0.6916 1
0.2181 0.3406 0.5197
0.7481 0.3291 0
0.0198 1 1
0.9441 1 1
0.0645 1 1
0.3347 0.561 0.561
0.4306 0.3769 0.3769
0.0637 1 0.5
1.365 1 1
0.3584 1 1
0.6509 1 0.5
0.106 1 1
0.0247 1 0.5
1.0378 0.4617 0.4617
1.6506 0.2713 0.2713
0.0247 1 0.5
0.363 1 1
1.2577 0.9999 0.9999
0.0247 1 0.5
0.3799 0.4063 0.4062
1.2363 1 1
0.0283 0.3404 0.3404
0.245 1 1
0.0247 0.2771 0.3537
0.2409 1 0.5
0.8421 1 1
0.0247 0.336 0.336
0.0742 1 1
0.0247 1 0.5
0.9849 1 1
1.4712 1 1
0.193 1 1
0.0444 0.5386 0
0.3907 1 0.5
0.8421 1 1
0.0388 0.2859 0.3342
0.8421 1 1
0.1491 1 1
0.0247 1 1
0.0247 1 0.5
0.1721 1 0.5
1.2196 1 1
0.0457 0.3855 0.4593
0.0677 0.7225 0.7225
0.919 1 1
0.4306 0.3769 0.3769
0.0247 0.8773 0.8773
0.1955 1 1
0.5129 1 1
0.759 1 1
0.104 1 0.5
1.2185 1 0.5
0.0247 0.2861 0.744
1.0083 1 0.5
0.8329 1 1
1.0378 0.4617 0.4617
0.8563 1 0.5
0.7414 1 1
0.0201 1 0.5
0.0247 0.2762 0.2762
0.0348 1 0.5
0.0687 1 1
0.0868 1 1
0.0247 1 0.5
0.0247 1 0.5
0.0964 1 1
1.0704 1 0.5
1.2771 1 0.5
1.0378 0.4617 0.4617
0.0247 1 0.5
0.1719 1 0.5
0.0388 0.2859 0.3342
0.4166 0.5611 0.5611
1.0307 0.688 0.688
0.1669 0.4045 0.4045
0.0247 0.2804 0.2781
0.0283 0.3383 0.3383
0.0846 1 0.5
0.0906 1 1
0.3786 0.6419 0.6417
0.4306 0.3769 0.3769
0.0592 0.6985 0.6985
0.0442 0.4953 0.4953
1.0581 1 0.5
0.0247 0.44 0.44
1.2252 1 1
0.0247 0.4776 0.4745
0.062 0.7222 0.7222
0.8421 1 1
0.0219 0.7637 1
1.0378 0.4617 0.4617
0.0247 1 0.5
0.0247 1 0.5
0.4032 0.5076 0.5076
0.7042 1 0.5
0.0495 1 0.5
1.0307 0.688 0.688
0.1691 1 1
0.0497 0.6434 0.8428
0.0388 0.2827 0.3335
1.0378 0.4617 0.4617
1.3888 1 1
0.0283 0.3383 0.3383
0.0247 1 1
1.0378 0.4617 0.4617
0.0283 0.3998 0.3945
0.5129 1 1
1.2973 1 1
0.0479 0.9694 0.9691
0.0514 0.264 0.3144
1.4455 0.7624 1
0.8421 1 1
0.0247 1 0.5
1.2528 1 1
0.0648 0.9723 0.9723
0.1775 1 0.5
0.009 1 1
0.0609 0.2744 0.2743
1.0378 0.4617 0.4617
0.2104 1 1
0.2011 0.804 0.804
0.0859 0.5608 0.5608
0.0089 1 1
0.9441 1 1
0.1137 1 1
1.0083 1 0.5
0.4747 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

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Gene identifier EmuJ_001116000 (Echinococcus multilocularis), sodium bile acid cotransporter
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