Detailed view for EmuJ_001088000

Basic information

TDR Targets ID: 961277
Echinococcus multilocularis, FERM and pleckstrin domain containing protein
Source Database / ID:  GeneDB

pI: 8.3213 | Length (AA): 1529 | MW (Da): 168193 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00169   PH domain
PF00373   FERM central domain
PF00621   RhoGEF domain
PF09379   FERM N-terminal domain
PF09380   FERM C-terminal PH-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005856   cytoskeleton  
GO:0005089   Rho guanyl-nucleotide exchange factor activity  
GO:0035023   regulation of Rho protein signal transduction  

Metabolic Pathways

Rap1 signaling pathway (KEGG)
Adherens junction (KEGG)

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
22 341 3pvl (A) 1226 1571 16.00 0 0.93 0.174387 0.84
50 430 4rm8 (A) 3 580 25.00 0 1 0.407282 0.18
50 340 2he7 (A) 108 388 38.00 0 1 0.63052 -0.32
52 340 3qij (A) 210 488 38.00 0 1 0.602112 -0.51
930 1488 4h6y (A) 541 1030 47.00 0 1 0.500798 0.23
931 1405 1xd4 (A) 202 652 15.00 0 1 0.244761 0.82
932 1298 2dx1 (A) 216 532 28.00 0.000018 1 0.212226 0.56
1179 1304 5efx (A) 445 574 13.00 0 0.77 0.249507 -0.69
1371 1488 4h6y (A) 859 1030 45.00 0 1 0.539275 -0.49
1371 1485 4gzu (B) 909 1025 50.00 0 1 0.633313 -0.38
1395 1485 1pls (A) 9 99 30.00 0.00045 0.85 0.402716 0.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131315)

Species Accession Gene Product
Caenorhabditis elegans CELE_F52D10.6   Protein F52D10.6
Drosophila melanogaster Dmel_CG44193   Chondrocyte-derived ezrin-like domain containing protein ortholog (H. sapiens)
Echinococcus granulosus EgrG_001088000   FERM and pleckstrin domain containing protein
Echinococcus multilocularis EmuJ_001088000   FERM and pleckstrin domain containing protein
Homo sapiens ENSG00000006607   FERM, RhoGEF and pleckstrin domain protein 2
Loa Loa (eye worm) LOAG_07569   hypothetical protein
Mus musculus ENSMUSG00000025555   FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
Mus musculus ENSMUSG00000034066   FERM, RhoGEF and pleckstrin domain protein 2
Schistosoma japonicum Sjp_0303270   FERM, RhoGEF and pleckstrin domain-containing protein 2, putative
Schistosoma mansoni Smp_125910   rhogef and pleckstrin domain protein
Schmidtea mediterranea mk4.018473.02   Putative 4.1 G protein
Schmidtea mediterranea mk4.010626.00  
Schmidtea mediterranea mk4.009841.04   Dab2-interacting protein-like
Schmidtea mediterranea mk4.016303.01   BcDNA.GH03163
Schmidtea mediterranea mk4.026085.00   Putative rhogef and pleckstrin domain protein
Schmidtea mediterranea mk4.001858.02  
Schmidtea mediterranea mk4.000695.01   BcDNA.GH03163
Schmidtea mediterranea mk4.001573.05   Putative 4.1 G protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_001088000 (Echinococcus multilocularis), FERM and pleckstrin domain containing protein
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