pI: 8.0538 |
Length (AA): 944 |
MW (Da): 105435 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
26 | 119 | 4u09 (A) | 306 | 399 | 37.00 | 0.0000000078 | 0.82 | 0.661176 | -1.24 |
36 | 118 | 4r6f (A) | 235 | 328 | 46.00 | 0.0000064 | 0.99 | 0.545524 | -0.43 |
36 | 125 | 1ook (G) | 76 | 167 | 36.00 | 0.019 | 0.84 | 0.524939 | -0.2 |
39 | 253 | 2v9t (B) | 302 | 467 | 30.00 | 0.14 | 1 | 0.231354 | 0.52 |
383 | 830 | 4z2b (A) | 199 | 608 | 23.00 | 0 | 1 | 0.568176 | 0.17 |
470 | 832 | 5dv4 (A) | 170 | 540 | 45.00 | 0 | 1 | 0.996334 | -1.22 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127911)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G58580 | DNAse I-like superfamily protein |
Arabidopsis thaliana | AT3G58560 | carbon catabolite repressor protein 4-like 1 |
Brugia malayi | Bm1_37535 | CCR4 |
Candida albicans | CaO19.5101 | potential mRNA deadenylase similar to S. cerevisiae CCR4 (YAL021C) ribonuclease component of the cytoplasmic mRNA deadenylase an |
Candida albicans | CaO19.12567 | potential mRNA deadenylase similar to S. cerevisiae CCR4 (YAL021C) ribonuclease component of the cytoplasmic mRNA deadenylase an |
Cryptosporidium hominis | Chro.40217 | hypothetical protein |
Cryptosporidium parvum | cgd4_1920 | hypothetical protein |
Dictyostelium discoideum | DDB_G0289461 | endonuclease/exonuclease/phosphatase domain-containing protein |
Drosophila melanogaster | Dmel_CG31137 | CG31137 gene product from transcript CG31137-RE |
Echinococcus granulosus | EgrG_000611400 | CCR4 NOT transcription complex subunit 6 |
Echinococcus multilocularis | EmuJ_000611400 | CCR4 NOT transcription complex subunit 6 |
Homo sapiens | ENSG00000138767 | CCR4-NOT transcription complex, subunit 6-like |
Homo sapiens | ENSG00000113300 | CCR4-NOT transcription complex, subunit 6 |
Loa Loa (eye worm) | LOAG_02052 | CCR4-NOT transcription complex subunit 6 family protein |
Mus musculus | ENSMUSG00000034724 | CCR4-NOT transcription complex, subunit 6-like |
Mus musculus | ENSMUSG00000020362 | CCR4-NOT transcription complex, subunit 6 |
Neospora caninum | NCLIV_027220 | Carbon catabolite repressor protein, related |
Oryza sativa | 4348610 | Os10g0412100 |
Oryza sativa | 4331740 | Os03g0166800 |
Plasmodium berghei | PBANKA_1234300 | carbon catabolite repressor protein 4, putative |
Plasmodium falciparum | PF3D7_0519500 | carbon catabolite repressor protein 4, putative |
Plasmodium knowlesi | PKNH_1013600 | carbon catabolite repressor protein 4, putative |
Plasmodium vivax | PVX_080270 | hypothetical protein, conserved |
Plasmodium yoelii | PY04723 | Arabidopsis thaliana At3g58560/F14P22_150-related |
Saccharomyces cerevisiae | YAL021C | Ccr4p |
Schistosoma japonicum | Sjp_0107760 | CCR4-NOT transcription complex subunit 6-like, putative |
Schistosoma japonicum | Sjp_0079730 | ko:K01175 CCR4-NOT transcription complex, subunit 6-like [EC:3.1.-.-], putative |
Schistosoma mansoni | Smp_172270 | carbon catabolite repressor protein |
Schmidtea mediterranea | mk4.000014.06 | Not6 |
Toxoplasma gondii | TGME49_259560 | endonuclease/exonuclease/phosphatase family protein |
Trichomonas vaginalis | TVAG_404050 | carbon catabolite repressor protein, putative |
Trichomonas vaginalis | TVAG_064670 | carbon catabolite repressor protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1234300 | Plasmodium berghei | Dispensable | plasmo |
TGME49_259560 | Toxoplasma gondii | Essentiality uncertain | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.