Detailed view for EmuJ_000433900

Basic information

TDR Targets ID: 962627
Echinococcus multilocularis, serine:threonine protein kinase RIO1
Source Database / ID:  GeneDB

pI: 8.9245 | Length (AA): 470 | MW (Da): 54054 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01163   RIO1 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004674   protein serine/threonine kinase activity  

Metabolic Pathways

Ribosome biogenesis in eukaryotes (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
32 277 1zth (A) 6 243 37.00 0 1 0.936104 -0.69
61 334 4otp (A) 163 430 50.00 0 1 0.888679 0.48

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127476)

Species Accession Gene Product
Arabidopsis thaliana AT2G24990   serine/threonine-protein kinase Rio1
Arabidopsis thaliana AT5G37350   Serine/threonine-protein kinase Rio1
Babesia bovis BBOV_IV008960   serine/threonine protein kinase, putative
Brugia malayi Bm1_49315   RIO1 family protein
Candida albicans CaO19.2320   chromosome condensation/seggregation
Candida albicans CaO19.9856   chromosome condensation/seggregation
Caenorhabditis elegans CELE_M01B12.5   Protein RIOK-1, isoform B
Cryptosporidium hominis Chro.50179   extragenic suppressor of the bimD6 mutation-related
Cryptosporidium parvum cgd5_2000   protein with RIO domain within N-terminal region
Dictyostelium discoideum DDB_G0280431   RIO family protein kinase
Drosophila melanogaster Dmel_CG11660   RIO kinase 1
Echinococcus granulosus EgrG_000433900   serine:threonine protein kinase RIO1
Entamoeba histolytica EHI_050990   RIO1 family protein
Echinococcus multilocularis EmuJ_000433900   serine:threonine protein kinase RIO1
Giardia lamblia GL50803_17449   RIO1-like protein
Homo sapiens ENSG00000124784   RIO kinase 1
Leishmania braziliensis LbrM.29.0250   hypothetical protein, conserved
Leishmania donovani LdBPK_290250.1   RIO1 family, putative
Leishmania infantum LinJ.29.0250   hypothetical protein, conserved
Leishmania major LmjF.29.0240   hypothetical protein, conserved
Leishmania mexicana LmxM.08_29.0240   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_00084   atypical/RIO/RIO1 protein kinase
Mus musculus ENSMUSG00000021428   RIO kinase 1 (yeast)
Neospora caninum NCLIV_011910   Testis cDNA clone: QtsA-11516, similar to human RIO kinase 3 (yeast) (RIOK3), transcript variant 1,, related
Oryza sativa 4342459   Os07g0162300
Plasmodium berghei PBANKA_1445600   serine/threonine protein kinase RIO1, putative
Plasmodium falciparum PF3D7_1230900   serine/threonine protein kinase RIO1, putative
Plasmodium knowlesi PKNH_1450300   serine/threonine protein kinase RIO1, putative
Plasmodium vivax PVX_124185   serine/threonine protein kinase RIO1, putative
Plasmodium yoelii PY01572   extragenic suppressor of the bimD6 mutation-related
Saccharomyces cerevisiae YOR119C   Rio1p
Schistosoma japonicum Sjp_0090620   ko:K07178 RIO kinase 1, putative
Schistosoma japonicum Sjp_0090610   ko:K07178 RIO kinase 1, putative
Schistosoma mansoni Smp_022140   serine/threonine-protein kinase rio1 (rio kinase 1)
Schmidtea mediterranea mk4.001217.01   Serine/threonine-protein kinase RIO1
Trypanosoma brucei gambiense Tbg972.3.6100   hypothetical protein, conserved
Trypanosoma brucei Tb927.3.5400   serine/threonine protein kinase RIO1, putative
Trypanosoma congolense TcIL3000_3_3340   RIO1 family, putative
Trypanosoma cruzi TcCLB.508409.150   serine/threonine protein kinase RIO1, putative
Toxoplasma gondii TGME49_210830   RIO1 family protein
Theileria parva TP01_0880   hypothetical protein
Trichomonas vaginalis TVAG_283340   RIO family atypical protein kinase

Essentiality

EmuJ_000433900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.5400 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.5400 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.5400 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.5400 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_M01B12.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_M01B12.5 Caenorhabditis elegans larval arrest wormbase
CELE_M01B12.5 Caenorhabditis elegans larval lethal wormbase
CELE_M01B12.5 Caenorhabditis elegans slow growth wormbase
CELE_M01B12.5 Caenorhabditis elegans sterile wormbase
YOR119C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1445600 Plasmodium berghei Slow plasmo
TGME49_210830 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens RIO kinase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EmuJ_000433900 (Echinococcus multilocularis), serine:threonine protein kinase RIO1
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