pI: 8.6287 |
Length (AA): 472 |
MW (Da): 51949 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
113 | 294 | 2ght (A) | 77 | 256 | 64.00 | 0 | 1 | 1.23289 | -1.23 |
306 | 418 | 4xhj (A) | 310 | 419 | 12.00 | 0 | 0 | 0.329007 | -0.2 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127075)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G45700 | haloacid dehalogenase-like hydrolase (HAD) superfamily protein |
Arabidopsis thaliana | AT1G29780 | Haloacid dehalogenase-like hydrolase (HAD) superfamily protein |
Arabidopsis thaliana | AT1G29770 | haloacid dehalogenase-like hydrolase |
Babesia bovis | BBOV_III004040 | Dullard-like phosphatase domain containing protein |
Brugia malayi | Bm1_47855 | Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 |
Candida albicans | CaO19.12861 | Plasma membrane Sodium Response 1 |
Candida albicans | CaO19.5406 | Plasma membrane Sodium Response 1 |
Caenorhabditis elegans | CELE_B0379.4 | Protein SCPL-1, isoform C |
Cryptosporidium hominis | Chro.20406 | hypothetical protein |
Cryptosporidium parvum | cgd2_3810 | hypothetical protein |
Dictyostelium discoideum | DDB_G0294376 | hypothetical protein |
Drosophila melanogaster | Dmel_CG8584 | CG8584 gene product from transcript CG8584-RA |
Drosophila melanogaster | Dmel_CG5830 | CG5830 gene product from transcript CG5830-RA |
Echinococcus granulosus | EgrG_001015050 | CTD small phosphatase protein like |
Echinococcus granulosus | EgrG_001046000 | Carboxy terminal domain RNA polymerase II |
Entamoeba histolytica | EHI_127190 | NLI interacting factor-like phosphatase domain-containing protein |
Echinococcus multilocularis | EmuJ_001015050 | |
Echinococcus multilocularis | EmuJ_001046000 | Carboxy terminal domain RNA polymerase II |
Giardia lamblia | GL50803_4063 | Nuclear LIM interactor-interacting factor 1 |
Homo sapiens | ENSG00000144579 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 |
Homo sapiens | ENSG00000144677 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like |
Homo sapiens | ENSG00000175215 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 |
Leishmania braziliensis | LbrM.25.1590 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_252110.1 | dullard-like phosphatase domain containing protein, putative |
Leishmania infantum | LinJ.25.2110 | hypothetical protein, conserved |
Leishmania major | LmjF.25.2030 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.25.2030 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_16239 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08577 | hypothetical protein |
Mus musculus | ENSMUSG00000026176 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 |
Mus musculus | ENSMUSG00000047409 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like |
Mus musculus | ENSMUSG00000078429 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 |
Neospora caninum | NCLIV_054710 | hypothetical protein |
Neospora caninum | NCLIV_018590 | hypothetical protein |
Oryza sativa | 4326854 | Os01g0665300 |
Oryza sativa | 4338072 | Os05g0205100 |
Plasmodium berghei | PBANKA_1403300 | NLI interacting factor-like phosphatase |
Plasmodium berghei | PBANKA_1115500 | NLI interacting factor-like phosphatase |
Plasmodium falciparum | PF3D7_0515900 | NLI interacting factor-like phosphatase, putative |
Plasmodium knowlesi | PKNH_1405000 | NLI interacting factor-like phosphatase, putative |
Plasmodium knowlesi | PKNH_1017300 | NLI interacting factor-like phosphatase, putative |
Plasmodium vivax | PVX_080450 | NLI interacting factor-like phosphatase, putative |
Plasmodium vivax | PVX_122077 | NLI interacting factor-like phosphatase, putative |
Plasmodium yoelii | PY00230 | NLI interacting factor, putative |
Plasmodium yoelii | PY00226 | NLI interacting factor, putative |
Saccharomyces cerevisiae | YLR019W | Psr2p |
Saccharomyces cerevisiae | YLL010C | Psr1p |
Schistosoma japonicum | Sjp_0083070 | ko:K01090 protein phosphatase [EC3.1.3.16], putative |
Schistosoma japonicum | Sjp_0200010 | CTD small phosphatase-like protein, putative |
Schistosoma mansoni | Smp_181170 | nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) |
Schistosoma mansoni | Smp_133240 | hypothetical protein |
Schistosoma mansoni | Smp_154650 | nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) |
Schmidtea mediterranea | mk4.002930.11 | |
Schmidtea mediterranea | mk4.003785.04 | |
Schmidtea mediterranea | mk4.000028.05 | |
Trypanosoma brucei gambiense | Tbg972.3.2050 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.3.2110 | Mitochondrial import inner membrane translocase subunit TIM50 |
Trypanosoma congolense | TcIL3000_0_10200 | TFIIF-stimulated CTD phosphatase, putative |
Trypanosoma congolense | TcIL3000_3_1220 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.507081.90 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_243990 | Dullard family phosphatase domain-containing protein |
Theileria parva | TP03_0026 | nuclear LIM interactor-interacting factor 1, putative |
Trichomonas vaginalis | TVAG_460790 | dullard protein, putative |
Trichomonas vaginalis | TVAG_225200 | nuclear lim interactor-interacting factor, putative |
Trichomonas vaginalis | TVAG_157570 | dullard protein, putative |
Trichomonas vaginalis | TVAG_053750 | nuclear lim interactor-interacting factor, putative |
Trichomonas vaginalis | TVAG_162430 | dullard protein, putative |
Trichomonas vaginalis | TVAG_084510 | nuclear lim interactor-interacting factor, putative |
Trichomonas vaginalis | TVAG_390460 | nuclear lim interactor-interacting factor, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.2110 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.2110 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.2110 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.3.2110 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1115500 | Plasmodium berghei | Slow | plasmo |
PBANKA_1403300 | Plasmodium berghei | Slow | plasmo |
TGME49_243990 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_243990 | Toxoplasma gondii | Probably non-essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 | Compounds | References |