Detailed view for EmuJ_000783100

Basic information

TDR Targets ID: 963051
Echinococcus multilocularis, ubiquitin
Source Database / ID:  GeneDB

pI: 6.8305 | Length (AA): 373 | MW (Da): 42246 | Paralog Number: 7

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00240   Ubiquitin family
PF11976   Ubiquitin-2 like Rad60 SUMO-like

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 371 5b83 (A) 14 297 29.00 0 1 0.954486 1.27
22 73 5tl7 (A) 101 152 42.00 0.00072 0.72 0.61611 0.07
90 156 1v86 (A) 32 93 37.00 0.44 0.72 0.492325 0.41
191 279 3vdz (A) 84 170 29.00 0 1 0.734706 -1.62

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126703)

Species Accession Gene Product
Arabidopsis thaliana AT1G65350   ubiquitin 13
Arabidopsis thaliana AT4G05050   ubiquitin 11
Arabidopsis thaliana AT3G09790   polyubiquitin 8
Arabidopsis thaliana AT4G05320   polyubiquitin 10
Arabidopsis thaliana AT5G03240   polyubiquitin 3
Arabidopsis thaliana AT2G35635   ubiquitin-like protein RUB2
Arabidopsis thaliana AT4G02890   polyubiquitin 14
Arabidopsis thaliana AT5G20620   ubiquitin 4
Babesia bovis BBOV_IV010030   polyubiquitin, putative
Brugia malayi Bm1_25395   ubiquitin
Brugia malayi Bm1_27905   polyubiquitin precursor
Candida albicans CaO19.6771   polyubiquitin involved in stress response system
Candida albicans CaO19.14063   polyubiquitin involved in stress response system
Caenorhabditis elegans CELE_F25B5.4   Protein UBQ-1, isoform C
Cryptosporidium hominis Chro.50123   ubiquitin B
Cryptosporidium parvum cgd5_2550   polyubiquitin with 3 Ub domains
Dictyostelium discoideum DDB_G0282295   hypothetical protein
Dictyostelium discoideum DDB_G0269458   hypothetical protein
Dictyostelium discoideum DDB_G0282369   hypothetical protein
Dictyostelium discoideum DDB_G0291928   hypothetical protein
Dictyostelium discoideum DDB_G0286907   hypothetical protein
Dictyostelium discoideum DDB_G0279721   hypothetical protein
Dictyostelium discoideum DDB_G0289449   hypothetical protein
Drosophila melanogaster Dmel_CG32744   Ubiquitin-5E
Drosophila melanogaster Dmel_CG11624   Ubiquitin-63E
Drosophila melanogaster Dmel_CG11700   CG11700 gene product from transcript CG11700-RB
Echinococcus granulosus EgrG_000783100   ubiquitin
Echinococcus granulosus EgrG_000782900   polyubiquitin
Echinococcus granulosus EgrG_001195600   ubiquitin
Echinococcus granulosus EgrG_000797400   polyubiquitin C
Echinococcus granulosus EgrG_001086700   UBiQuitin family member ubq 1
Echinococcus granulosus EgrG_001195700   polyubiquitin
Echinococcus granulosus EgrG_000516800   ubiquitin ribosomal protein L40
Echinococcus granulosus EgrG_000516500   polyubiquitin
Echinococcus granulosus EgrG_001168600   ubiquitin ribosomal protein L40
Entamoeba histolytica EHI_156660   ubiquitin, putative
Entamoeba histolytica EHI_178340   ubiquitin, putative
Entamoeba histolytica EHI_083270   ubiquitin, putative
Entamoeba histolytica EHI_083410   ubiquitin, putative
Entamoeba histolytica EHI_166800   ubiquitin, putative
Echinococcus multilocularis EmuJ_001086700   UBiQuitin family member (ubq 1)
Echinococcus multilocularis EmuJ_001168600   ubiquitin (ribosomal protein L40)
Echinococcus multilocularis EmuJ_000782900   polyubiquitin
Echinococcus multilocularis EmuJ_000516800   ubiquitin (ribosomal protein L40)
Echinococcus multilocularis EmuJ_000797400   polyubiquitin C
Echinococcus multilocularis EmuJ_000516500   polyubiquitin
Echinococcus multilocularis EmuJ_001195700   polyubiquitin
Echinococcus multilocularis EmuJ_000783100   ubiquitin
Giardia lamblia GL50803_7110   Ubiquitin
Homo sapiens ENSG00000170315   ubiquitin B
Homo sapiens ENSG00000150991   ubiquitin C
Leishmania braziliensis LbrM.26.2680   polyubiquitin, putative
Leishmania braziliensis LbrM.35.3760   polyubiquitin, putative
Leishmania donovani LdBPK_311930.1   ubiquitin-fusion protein
Leishmania infantum LinJ.09.0950   polyubiquitin
Leishmania infantum LinJ.36.3690   polyubiquitin, putative
Leishmania major LmjF.36.3530   polyubiquitin, putative
Leishmania mexicana LmxM.09.0891   polyubiquitin, putative
Loa Loa (eye worm) LOAG_06978   ubiquitin C II
Loa Loa (eye worm) LOAG_04428   polyubiquitin 1
Mus musculus ENSMUSG00000008348   ubiquitin C
Mus musculus 22187   ubiquitin B
Neospora caninum NCLIV_060800   Ubiquitin, related
Oryza sativa 4337080   Os04g0628100
Oryza sativa 4341814   Os06g0673500
Oryza sativa 4328390   Os02g0161900
Oryza sativa 4347232   Os09g0452700
Oryza sativa 9266345   Os05g0457400
Oryza sativa 9272016   Os05g0504766
Oryza sativa 4343261   Os07g0489500
Oryza sativa 4341860   Os06g0681400
Onchocerca volvulus OVOC12681  
Onchocerca volvulus OVOC12741  
Plasmodium berghei PBANKA_0610300   polyubiquitin, putative
Plasmodium falciparum PF3D7_1211800   polyubiquitin
Plasmodium knowlesi PKNH_1311900   ubiquitin, putative
Plasmodium vivax PVX_084620   polyubiquitin 5, putative
Plasmodium yoelii PY03971   Unknown protein
Saccharomyces cerevisiae YLL039C   ubiquitin
Schistosoma japonicum Sjp_0031660   ko:K08770 ubiquitin C, putative
Schistosoma japonicum Sjp_0212180   ko:K08770 ubiquitin C, putative
Schistosoma mansoni Smp_009580   ubiquitin (ribosomal protein L40)
Schistosoma mansoni Smp_046690   ubiquitin (ribosomal protein L40)
Schistosoma mansoni Smp_147210   ubiquitin (ribosomal protein L40)
Schmidtea mediterranea mk4.007135.01  
Schmidtea mediterranea mk4.002808.04  
Schmidtea mediterranea mk4.002174.07  
Trypanosoma brucei Tb11.01.1680.v5   polyubiquitin, putative
Trypanosoma brucei Tb927.11.13003   ubiquitin-60S ribosomal protein L40
Trypanosoma brucei Tb927.11.9920   polyubiquitin, putative
Trypanosoma brucei Tb927.11.13007   ubiquitin-60S ribosomal protein L40
Trypanosoma brucei Tb11.v5.0537   polyubiquitin, putative
Trypanosoma congolense TcIL3000.11.10410   polyubiquitin, putative
Toxoplasma gondii TGME49_219820   polyubiquitin UbC, putative
Toxoplasma gondii TGME49_223125   ubiquitin family protein
Theileria parva TP01_0721   ubiquitin, putative
Trichomonas vaginalis TVAG_120450   ubiquitin, putative
Trichomonas vaginalis TVAG_069570   ubiquitin 1, putative
Trichomonas vaginalis TVAG_441950   ubiquitin, putative
Trichomonas vaginalis TVAG_441960   ubiquitin, putative
Trichomonas vaginalis TVAG_184170   ubiquitin 1, putative
Trichomonas vaginalis TVAG_110540   ubiquitin, putative
Trichomonas vaginalis TVAG_174180   ubiquitin, putative
Trichomonas vaginalis TVAG_264700   ubiquitin, putative
Trichomonas vaginalis TVAG_120440   ubiquitin, putative
Trichomonas vaginalis TVAG_184150   ubiquitin, putative
Trichomonas vaginalis TVAG_120290   ubiquitin, putative
Trichomonas vaginalis TVAG_159980   ubiquitin, putative

Essentiality

EmuJ_000783100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.1680 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.1680 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.1680 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.1680 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F25B5.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_F25B5.4 Caenorhabditis elegans larval arrest wormbase
CELE_F25B5.4 Caenorhabditis elegans larval lethal wormbase
CELE_F25B5.4 Caenorhabditis elegans sterile wormbase
PBANKA_0610300 Plasmodium berghei Essential plasmo
TGME49_219820 Toxoplasma gondii Probably essential sidik
TGME49_223125 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0036 0.3285 0.3285
0.0037 0.2503 0.2503
0.0031 0.4927 0.4927
0.0037 0.2574 0.2574
0.0035 0.3325 0.3325
0.0036 0.3285 0.3285

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000783100 (Echinococcus multilocularis), ubiquitin
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