Detailed view for EmuJ_000911900

Basic information

TDR Targets ID: 963056
Echinococcus multilocularis, phospholipid transporting ATPase VA
Source Database / ID:  GeneDB

pI: 7.6283 | Length (AA): 1523 | MW (Da): 171202 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00702   haloacid dehalogenase-like hydrolase
PF13246   Cation transport ATPase (P-type)
PF16212   Phospholipid-translocating P-type ATPase C-terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0005524   ATP binding  
GO:0004012   phospholipid-translocating ATPase activity  
GO:0000287   magnesium ion binding  
GO:0000166   nucleotide binding  
GO:0015914   phospholipid transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
894 931 4bbj (A) 551 588 39.00 0.11 1 0.534251 -0.29
1078 1108 5is2 (A) 337 367 42.00 0.82 0.36 0.536655 -0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128792)

Species Accession Gene Product
Candida albicans CaO19.2680   Drs2 family of the P-type ATPase superfamily
Candida albicans CaO19.10195   Drs2 family of the P-type ATPase superfamily
Caenorhabditis elegans CELE_W09D10.2   Protein TAT-3
Cryptosporidium hominis Chro.70206   adenosinetriphosphatase 2
Drosophila melanogaster Dmel_CG4301   CG4301 gene product from transcript CG4301-RC
Drosophila melanogaster Dmel_CG33298   CG33298 gene product from transcript CG33298-RB
Echinococcus granulosus EgrG_000911800   phospholipid transporting atpase
Echinococcus granulosus EgrG_000911900   phospholipid transporting ATPase VA
Entamoeba histolytica EHI_140130   phospholipid-transporting P-type ATPase, putative
Echinococcus multilocularis EmuJ_000912000   phospholipid transporting ATPase VB
Echinococcus multilocularis EmuJ_000911800   phospholipid transporting atpase
Echinococcus multilocularis EmuJ_000911900   phospholipid transporting ATPase VA
Homo sapiens ENSG00000118322   ATPase, class V, type 10B
Homo sapiens 57194   ATPase, class V, type 10A
Homo sapiens ENSG00000145246   ATPase, class V, type 10D
Mus musculus ENSMUSG00000025324   ATPase, class V, type 10A
Mus musculus ENSMUSG00000055415   ATPase, class V, type 10B
Mus musculus ENSMUSG00000046808   ATPase, class V, type 10D
Saccharomyces cerevisiae YMR162C   aminophospholipid-translocating P4-type ATPase DNF3
Schistosoma japonicum Sjp_0107900   Probable phospholipid-transporting ATPase VD, putative
Schistosoma japonicum Sjp_0110280   Probable phospholipid-transporting ATPase VB, putative
Schistosoma japonicum Sjp_0055810   Probable phospholipid-transporting ATPase VD, putative
Schistosoma japonicum Sjp_0084380   ko:K01530 phospholipid-translocating ATPase [EC3.6.3.1], putative
Schistosoma mansoni Smp_181230   phospholipid-transporting atpase
Schmidtea mediterranea mk4.001225.16  
Schmidtea mediterranea mk4.004081.02  
Schmidtea mediterranea mk4.005632.01  
Schmidtea mediterranea mk4.000005.39  
Schmidtea mediterranea mk4.001225.14   Phospholipid-transporting atpase
Schmidtea mediterranea mk4.000005.37  
Schmidtea mediterranea mk4.000512.02  
Schmidtea mediterranea mk4.001225.13  
Schmidtea mediterranea mk4.000005.40   Phospholipid-transporting atpase
Schmidtea mediterranea mk4.000005.36  
Schmidtea mediterranea mk4.000005.32   Phospholipid-transporting atpase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000911900 (Echinococcus multilocularis), phospholipid transporting ATPase VA
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