Detailed view for EmuJ_001028900

Basic information

TDR Targets ID: 963305
Echinococcus multilocularis, serine:threonine protein kinase 36
Source Database / ID:  GeneDB

pI: 7.5644 | Length (AA): 1469 | MW (Da): 161509 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005488   binding  
GO:0004672   protein kinase activity  
GO:0005524   ATP binding  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

Hedgehog signaling pathway - fly (KEGG)

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 255 2y7j (A) 22 292 34.00 0 1 0.631607 -1.05
2 399 3hzt (A) 74 489 25.00 0 1 0.535633 -0.11
4 200 5ebz (A) 15 221 38.00 0 1 0.395005 0.67
16 266 2x4f (A) 113 373 32.00 0 1 0.610565 -0.76
24 309 5ce3 (B) 152 460 21.00 0.000000045 1 0.30139 0.47
61 254 3aln (C) 159 367 37.00 0 1 0.0467626 1.09
437 1469 1u6g (C) 27 1116 12.00 0 1 0.736599 0.76
1231 1410 4rzp (A) 35 217 21.00 0.65 1 0.465232 -1.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130036)

Species Accession Gene Product
Arabidopsis thaliana AT1G50240   serine/threonine-protein kinase FUSED
Caenorhabditis elegans CELE_F32D8.1   Protein F32D8.1
Dictyostelium discoideum DDB_G0267962   ULK family protein kinase
Drosophila melanogaster Dmel_CG6551   fused
Echinococcus granulosus EgrG_001028900   serine:threonine protein kinase 36
Echinococcus multilocularis EmuJ_001028900   serine:threonine protein kinase 36
Giardia lamblia GL50803_17368   Kinase, ULK
Homo sapiens ENSG00000163482   serine/threonine kinase 36
Leishmania braziliensis LbrM.13.0260   mitogen-activated protein kinase kinase 2
Leishmania donovani LdBPK_130280.1   mitogen-activated protein kinase kinase 2
Leishmania infantum LinJ.13.0280   mitogen-activated protein kinase kinase 2
Leishmania major LmjF.13.0440   mitogen-activated protein kinase kinase 2
Leishmania mexicana LmxM.13.0440   mitogen-activated protein kinase kinase 2
Mus musculus ENSMUSG00000033276   serine/threonine kinase 36
Oryza sativa 4352122   Os12g0433500
Schistosoma japonicum Sjp_0026310   ko:K06228 fused,Serine/threonine protein kinase, putative
Schistosoma mansoni Smp_132260   serine/threonine protein kinase
Schmidtea mediterranea mk4.014854.00  
Schmidtea mediterranea mk4.020170.00   Fused-like protein
Schmidtea mediterranea mk4.020170.01   Serine/threonine-protein kinase 36
Schmidtea mediterranea mk4.009350.00  
Trypanosoma brucei gambiense Tbg972.11.5110   protein kinase, putative,serine/threonine protein kinase, putative
Trypanosoma brucei Tb927.11.4470   ULK family serine/threonine-protein kinase, putative
Trypanosoma congolense TcIL3000.11.4540   serine/threonine protein kinase, putative
Trypanosoma cruzi TcCLB.504089.54   ULK family serine/threonine-protein kinase, putative
Trypanosoma cruzi TcCLB.504001.6   ULK family serine/threonine-protein kinase, putative
Trichomonas vaginalis TVAG_196800   CAMK family protein kinase
Trichomonas vaginalis TVAG_368920   CAMK family protein kinase
Trichomonas vaginalis TVAG_462850   AGC family protein kinase

Essentiality

EmuJ_001028900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.2050 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.2050 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.2050 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.2050 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens serine/threonine kinase 36 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Patiria pectinifera Cdc2 300 aa 30.1% 289 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 30.4% 312 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 29.9% 291 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 29.5% 281 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 33.7% 306 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 27.6% 323 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 29.2% 291 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 35.7% 157 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0039 0.9485 0.9402
0.0033 1 1
0.0081 1 1
0.0066 0.3101 0.9479
0.0059 1 1
0.0004 0.5 0.5
0.0081 0.5 0.5
0.0039 0.5 0.5
0.0042 0.5 0.5
0.0067 0.5 0.5
0.0022 0.5 0.5
0.0036 0.5 0.5
0.0008 0.5 0.5
0.0026 0.5 0.5
0.0091 1 1
0.0012 0.5 0.5
0.0027 1 1
0.0069 0.3067 0.3067
0.0032 0.5 0.5
0.0061 0.6883 0.6883
0.0063 0.7244 0
0.0039 0.5 0.5
0.0092 1 1
0.0007 0.5 0.5
0.0003 0.5 0.5
0.0023 0.5 0.5
0.0011 1 1
0.0062 0.6935 0.7231
0.0029 0.5 0.5
0.0093 0.8828 0
0.0018 0.5 0.5
0.0037 1 1
0.0032 0.5 0.5
0.0059 1 1
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0007 0.5 0.5
0.0064 0.3377 0.9531
0.0059 1 1
0.0007 0.5 0.5
0.0033 0.5 0.5
0.0012 0.5 0.5
0.0098 0.3242 0.2282
0.0063 1 1
0.0056 1 1
0.0088 0.4477 0.4477
0.0016 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier EmuJ_001028900 (Echinococcus multilocularis), serine:threonine protein kinase 36
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