Detailed view for EmuJ_000171900

Basic information

TDR Targets ID: 963332
Echinococcus multilocularis, histone acetyltransferase myst4
Source Database / ID:  GeneDB

pI: 8.3765 | Length (AA): 1730 | MW (Da): 188568 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00628   PHD-finger
PF01853   MOZ/SAS family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016573   histone acetylation  
GO:0006355   regulation of transcription, DNA-dependent  
GO:0004402   histone acetyltransferase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
123 251 5b78 (A) 202 310 49.00 0 1 0.428166 0.41
210 251 2mny (A) 316 356 54.00 0.000005 0.98 0.620877 0.06
211 252 2puy (A) 492 533 50.00 0.0000032 1 0.686877 -0.78
635 931 5wci (A) 165 447 46.00 0 1 0.726876 -1.1
638 939 5j9u (E) 155 441 44.00 0 1 0.691767 -0.94
647 932 2rc4 (A) 507 779 59.00 0 1 0.808918 -0.49

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131853)

Species Accession Gene Product
Brugia malayi Bm1_08860   MOZ/SAS family protein
Drosophila melanogaster Dmel_CG11290   enoki mushroom
Echinococcus granulosus EgrG_000171900   histone acetyltransferase myst4
Echinococcus multilocularis EmuJ_000171900   histone acetyltransferase myst4
Homo sapiens ENSG00000083168   K(lysine) acetyltransferase 6A
Homo sapiens ENSG00000156650   K(lysine) acetyltransferase 6B
Loa Loa (eye worm) LOAG_06919   hypothetical protein
Mus musculus ENSMUSG00000021767   K(lysine) acetyltransferase 6B
Mus musculus ENSMUSG00000031540   K(lysine) acetyltransferase 6A
Schmidtea mediterranea mk4.002285.03   Putative myst histone acetyltransferase
Trichomonas vaginalis TVAG_285090   myst histone acetyltransferase, putative
Trichomonas vaginalis TVAG_408380   mst1, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000171900 (Echinococcus multilocularis), histone acetyltransferase myst4
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