pI: 9.3808 |
Length (AA): 439 |
MW (Da): 49079 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
26 | 419 | 3q5i (A) | 30 | 393 | 25.00 | 0 | 1 | 0.958994 | 0.42 |
41 | 396 | 1j1b (A) | 36 | 372 | 56.00 | 0 | 1 | 1.42243 | -0.58 |
55 | 438 | 3hx4 (A) | 49 | 396 | 29.00 | 0 | 1 | 0.964215 | 0.64 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126888)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G61160 | shaggy-related protein kinase beta |
Arabidopsis thaliana | AT2G30980 | Shaggy-related protein kinase zeta |
Arabidopsis thaliana | AT3G05840 | Shaggy-related protein kinase gamma |
Arabidopsis thaliana | AT1G57870 | shaggy-related protein kinase delta |
Arabidopsis thaliana | AT4G00720 | Shaggy-related protein kinase theta |
Arabidopsis thaliana | AT5G14640 | Shaggy-related protein kinase 13 |
Arabidopsis thaliana | AT1G09840 | Shaggy-related protein kinase kappa |
Arabidopsis thaliana | AT4G18710 | Shaggy-related protein kinase eta |
Arabidopsis thaliana | AT1G06390 | shaggy-related protein kinase iota |
Arabidopsis thaliana | AT5G26751 | Shaggy-related protein kinase alpha |
Babesia bovis | BBOV_III003600 | protein kinase domain containing protein |
Brugia malayi | Bm1_49835 | intracellular kinase |
Candida albicans | CaO19.8410 | second truncated form of RIM11 Serine/threonine protein kinase |
Candida albicans | CaO19.1594 | hypothetical protein |
Candida albicans | CaO19.1593 | Serine/threonine protein kinase required for induction of IME2 by Ime1p |
Candida albicans | CaO19.791 | second truncated form of RIM11 Serine/threonine protein kinase |
Caenorhabditis elegans | CELE_Y18D10A.5 | Protein GSK-3 |
Cryptosporidium hominis | Chro.40038 | hypothetical protein |
Cryptosporidium parvum | cgd4_240 | hypothetical protein |
Dictyostelium discoideum | DDB_G0270218 | GSK family protein kinase |
Dictyostelium discoideum | DDB_G0272110 | GSK family protein kinase |
Drosophila melanogaster | Dmel_CG2621 | shaggy |
Drosophila melanogaster | Dmel_CG31003 | gasket |
Echinococcus granulosus | EgrG_000980300 | glycogen synthase kinase 3 beta |
Echinococcus granulosus | EgrG_000352700 | protein kinase shaggy |
Entamoeba histolytica | EHI_003900 | protein kinase domain containing protein |
Entamoeba histolytica | EHI_121880 | protein kinase domain containing protein |
Entamoeba histolytica | EHI_148220 | protein kinase, putative |
Echinococcus multilocularis | EmuJ_000980300 | glycogen synthase kinase 3 beta |
Echinococcus multilocularis | EmuJ_000352700 | protein kinase shaggy |
Giardia lamblia | GL50803_9116 | Kinase, CMGC GSK |
Giardia lamblia | GL50803_17625 | Kinase, CMGC GSK |
Homo sapiens | ENSG00000105723 | glycogen synthase kinase 3 alpha |
Homo sapiens | ENSG00000082701 | glycogen synthase kinase 3 beta |
Leishmania braziliensis | LbrM.18.0290 | protein kinase, putative,glycogen synthase kinase, putative |
Leishmania donovani | LdBPK_180270.1 | glycogen synthase kinase 3, putative |
Leishmania infantum | LinJ.18.0270 | glycogen synthase kinase 3 |
Leishmania major | LmjF.18.0270 | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 |
Leishmania mexicana | LmxM.18.0270 | protein kinase, putative,glycogen synthase kinase, putative |
Loa Loa (eye worm) | LOAG_09639 | CMGC/GSK protein kinase |
Loa Loa (eye worm) | LOAG_03082 | CMGC/GSK protein kinase |
Mus musculus | ENSMUSG00000057177 | glycogen synthase kinase 3 alpha |
Mus musculus | ensembl-mmu:ENSMUSG00000022812 | glycogen synthase kinase 3 beta |
Neospora caninum | NCLIV_039940 | hypothetical protein |
Oryza sativa | 4334738 | Os03g0841800 |
Oryza sativa | 4338079 | Os05g0207500 |
Oryza sativa | 4327108 | Os01g0252100 |
Oryza sativa | 4349147 | Os10g0521700 |
Oryza sativa | 4337722 | Os05g0134000 |
Oryza sativa | 4341251 | Os06g0547900 |
Oryza sativa | 4328830 | Os02g0236200 |
Oryza sativa | 9268935 | Os03g0679300 |
Oryza sativa | 4326720 | Os01g0296100 |
Onchocerca volvulus | OVOC3893 |
|
Plasmodium berghei | PBANKA_0410400 | glycogen synthase kinase 3, putative |
Plasmodium falciparum | PF3D7_0312400 | glycogen synthase kinase 3 |
Plasmodium knowlesi | PKNH_0829800 | glycogen synthase kinase 3, putative |
Plasmodium vivax | PVX_119725 | glycogen synthase kinase 3, putative |
Plasmodium yoelii | PY01719 | Protein kinase domain, putative |
Saccharomyces cerevisiae | YDL079C | Mrk1p |
Saccharomyces cerevisiae | YMR139W | Rim11p |
Schistosoma japonicum | Sjp_0026020 | ko:K08822 glycogen synthase kinase 3 alpha, putative |
Schistosoma mansoni | Smp_008260 | glycogen synthase kinase 3-related (gsk3) (cmgc group III) |
Schmidtea mediterranea | mk4.029485.00 | |
Schmidtea mediterranea | mk4.020670.01 | Putative glycogen synthase kinase 3-related |
Schmidtea mediterranea | mk4.007751.00 | Putative glycogen synthase kinase 3-related |
Schmidtea mediterranea | mk4.007159.01 | Glycogen synthase kinase 3 |
Schmidtea mediterranea | mk4.028540.00 | Putative glycogen synthase kinase 3-related |
Schmidtea mediterranea | mk4.004470.03 | Putative glycogen synthase kinase 3-related |
Schmidtea mediterranea | mk4.019543.00 | |
Schmidtea mediterranea | mk4.000777.01 | |
Schmidtea mediterranea | mk4.036542.00 | |
Schmidtea mediterranea | mk4.012060.00 | Glycogen synthase kinase 3 |
Trypanosoma brucei gambiense | Tbg972.10.16930 | protein kinase, putative,glycogen synthase kinase, putative |
Trypanosoma brucei | Tb11.v5.0718 | protein kinase, putative |
Trypanosoma congolense | TcIL3000_10_11890 | protein kinase, putative |
Trypanosoma cruzi | TcCLB.507993.80 | glycogen synthase kinase 3, putative |
Toxoplasma gondii | TGME49_265330 | cell-cycle-associated protein kinase GSK, putative |
Theileria parva | TP03_0047 | glycogen synthase kinase, putative |
Trichomonas vaginalis | TVAG_046830 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_214690 | CMGC family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.13780 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.13780 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.13780 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.13780 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y18D10A.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y18D10A.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y18D10A.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y18D10A.5 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0410400 | Plasmodium berghei | Dispensable | plasmo |
TGME49_265330 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 alpha | Compounds | References |
Sus scrofa | Glycogen synthase kinase-3 | Compounds | References |
Mus musculus | glycogen synthase kinase 3 alpha | Compounds | References |
Rattus norvegicus | Glycogen synthase kinase-3 beta | Compounds | References |
Mus musculus | glycogen synthase kinase 3 beta | Compounds | References |
Plasmodium falciparum | glycogen synthase kinase 3 | Compounds | References |
Homo sapiens | glycogen synthase kinase 3 beta | Compounds | References |
Sus scrofa | Glycogen synthase kinase 3 beta | Compounds | References |
Dictyostelium discoideum | GSK family protein kinase | Compounds | References |
Bos taurus | Glycogen synthase kinase-3 beta splice variant X1 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 35.0% | 317 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 30.3% | 317 aa | Compounds | References |
Rattus norvegicus | Jak1 protein | 210 aa | 25.6% | 223 aa | Compounds | References |
Oryctolagus cuniculus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 24.6% | 284 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 32.7% | 315 aa | Compounds | References |
Rattus norvegicus | MAP kinase p38 alpha | 360 aa | 32.2% | 317 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 32.6% | 187 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 29.9% | 318 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 8 | 411 aa | 31.8% | 337 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 29.9% | 321 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 1 | 358 aa | 31.3% | 351 aa | Compounds | References |