pI: 6.2297 |
Length (AA): 2195 |
MW (Da): 248109 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
35 | 192 | 5cwf (A) | 10 | 165 | 28.00 | 0.078 | 0.91 | 0.238282 | -0.24 |
106 | 2195 | 5dca (A) | 113 | 2163 | 37.00 | 0 | 1 | 1.29776 | 0.16 |
245 | 362 | 4rvq (A) | 0 | 410 | 31.00 | 0 | 1 | 0.545459 | -1.49 |
407 | 2193 | 4f92 (B) | 404 | 2125 | 66.00 | 0 | 1 | 1.59872 | -0.73 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126701)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G61140 | U5 small nuclear ribonucleoprotein helicase |
Arabidopsis thaliana | AT1G20960 | putative U5 small nuclear ribonucleoprotein helicase |
Arabidopsis thaliana | AT2G42270 | U5 small nuclear ribonucleoprotein helicase |
Babesia bovis | BBOV_III000950 | sec63 domain containing protein |
Babesia bovis | BBOV_I001530 | helicase, putative |
Brugia malayi | Bm1_28570 | Type III restriction enzyme, res subunit family protein |
Brugia malayi | Bm1_10275 | Type III restriction enzyme, res subunit family protein |
Brugia malayi | Bm1_43145 | U5 small nuclear ribonucleoprotein 200 kDa helicase, putative |
Candida albicans | CaO19.10610 | similar to S. cerevisiae BRR2 (YER172C) spliceosomal U5 snRNP RNA helicase |
Candida albicans | CaO19.11463 | similar to S. cerevisiae SLH1 (YGR271W) putative helicase implicated in translation regulation |
Candida albicans | CaO19.3098 | similar to S. cerevisiae BRR2 (YER172C) spliceosomal U5 snRNP RNA helicase |
Candida albicans | CaO19.3980 | similar to S. cerevisiae SLH1 (YGR271W) putative helicase implicated in translation regulation |
Caenorhabditis elegans | CELE_Y54E2A.4 | Protein Y54E2A.4 |
Caenorhabditis elegans | CELE_Y46G5A.4 | Protein SNRP-200 |
Cryptosporidium hominis | Chro.20293 | hypothetical protein |
Cryptosporidium hominis | Chro.50077 | hypothetical protein |
Cryptosporidium parvum | cgd5_2960 | U5snrp Brr2 SFII RNA helicase (sec63 and the second part of the RNA |
Cryptosporidium parvum | cgd2_2770 | U5 small nuclear ribonucleoprotein 200kDA helicase, Pre-mRNA splicing helicase BRR2 2 (RNA helicase plus Sec63 domain) |
Dictyostelium discoideum | DDB_G0270042 | DEAD/DEAH box helicase |
Dictyostelium discoideum | DDB_G0290389 | DEAD/DEAH box helicase |
Drosophila melanogaster | Dmel_CG5205 | CG5205 gene product from transcript CG5205-RA |
Drosophila melanogaster | Dmel_CG5931 | lethal (3) 72Ab |
Echinococcus granulosus | EgrG_001009800 | U5 small nuclear ribonucleoprotein 200 kDa |
Echinococcus granulosus | EgrG_001152700 | Activating signal cointegrator 1 complex subunit |
Entamoeba histolytica | EHI_131080 | DEAD/DEAH box helicase, putative |
Entamoeba histolytica | EHI_045170 | U5 snRNP-specific 200kd protein, putative |
Echinococcus multilocularis | EmuJ_001152700 | Activating signal cointegrator 1 complex subunit |
Echinococcus multilocularis | EmuJ_001009800 | U5 small nuclear ribonucleoprotein 200 kDa |
Giardia lamblia | GL50803_87022 | RNA helicase |
Giardia lamblia | GL50803_9352 | U5 small nuclear ribonucleoprotein 200 kDa helicase, putative |
Homo sapiens | ENSG00000112249 | activating signal cointegrator 1 complex subunit 3 |
Homo sapiens | ENSG00000144028 | small nuclear ribonucleoprotein 200kDa (U5) |
Leishmania braziliensis | LbrM.13.0320 | RNA helicase, putative |
Leishmania braziliensis | LbrM.17.0940 | ATP-dependent RNA helicase, putative |
Leishmania donovani | LdBPK_171020.1 | ATP-dependent RNA helicase, putative |
Leishmania donovani | LdBPK_130390.1 | ATP-dependent RNA helicase, putative |
Leishmania infantum | LinJ.17.1030 | ATP-dependent RNA helicase, putative |
Leishmania infantum | LinJ.13.0390 | RNA helicase, putative |
Leishmania major | LmjF.17.0920 | ATP-dependent RNA helicase, putative |
Leishmania major | LmjF.13.0500 | RNA helicase, putative |
Leishmania mexicana | LmxM.17.0920 | ATP-dependent RNA helicase, putative |
Leishmania mexicana | LmxM.13.0500 | RNA helicase, putative |
Loa Loa (eye worm) | LOAG_11428 | ASCC3L1 protein |
Loa Loa (eye worm) | LOAG_05326 | U5 small nuclear ribonucleoprotein helicase |
Loa Loa (eye worm) | LOAG_01392 | hypothetical protein |
Mus musculus | ENSMUSG00000003660 | small nuclear ribonucleoprotein 200 (U5) |
Mus musculus | ENSMUSG00000038774 | activating signal cointegrator 1 complex subunit 3 |
Neospora caninum | NCLIV_049050 | RNA helicase-related protein required for pre- mRNA splicing (EC 3.6.1.-), related |
Neospora caninum | NCLIV_065940 | hypothetical protein |
Oryza sativa | 4332045 | Os03g0213400 |
Onchocerca volvulus | OVOC11367 | Activating signal cointegrator 1 complex subunit 3 homolog |
Plasmodium berghei | PBANKA_0522900 | pre-mRNA-splicing helicase BRR2, putative |
Plasmodium berghei | PBANKA_1303000 | DEAD/DEAH box helicase, putative |
Plasmodium falciparum | PF3D7_1439100 | DEAD/DEAH box helicase, putative |
Plasmodium falciparum | PF3D7_0422500 | pre-mRNA-splicing helicase BRR2, putative |
Plasmodium knowlesi | PKNH_0514400 | pre-mRNA-splicing helicase BRR2, putative |
Plasmodium knowlesi | PKNH_1243200 | DEAD/DEAH box helicase, putative |
Plasmodium vivax | PVX_090165 | pre-mRNA-splicing helicase BRR2, putative |
Plasmodium vivax | PVX_118535 | RNA helicase, putative |
Plasmodium yoelii | PY05116 | Unknown-related |
Plasmodium yoelii | PY04061 | Drosophila melanogaster CG5931 gene product-related |
Plasmodium yoelii | PY00412 | RNA helicase-related |
Saccharomyces cerevisiae | YGR271W | Slh1p |
Saccharomyces cerevisiae | YER172C | Brr2p |
Schistosoma japonicum | Sjp_0081280 | ko:K01529 ASCC3, HELIC1; activating signal cointegrator 1 complex subunit 3 [EC:3.6.1.-], putative |
Schistosoma japonicum | Sjp_0127560 | Activating signal cointegrator 1 complex subunit 3, putative |
Schistosoma japonicum | Sjp_0210030 | similar to U5 small nuclear ribonucleoprotein 200 kDa helicase, putative |
Schistosoma japonicum | Sjp_0090490 | Activating signal cointegrator 1 complex subunit 3, putative |
Schistosoma japonicum | Sjp_0062470 | expressed protein |
Schistosoma japonicum | Sjp_0210000 | ko:K01529 ASCC3L1; activating signal cointegrator 1 complex subunit 3-like 1 [EC:3.6.1.-], putative |
Schistosoma japonicum | Sjp_0124530 | Activating signal cointegrator 1 complex subunit 3, putative |
Schistosoma japonicum | Sjp_0209990 | similar to U5 small nuclear ribonucleoprotein 200 kDa helicase, putative |
Schistosoma japonicum | Sjp_0210010 | similar to U5 small nuclear ribonucleoprotein 200 kDa helicase, putative |
Schistosoma japonicum | Sjp_0210020 | similar to U5 small nuclear ribonucleoprotein 200 kDa helicase, putative |
Schistosoma mansoni | Smp_156920 | activating signal cointegrator 1 complex subunit 3 helc1 |
Schistosoma mansoni | Smp_105700 | U520 |
Schmidtea mediterranea | mk4.008198.03 | |
Schmidtea mediterranea | mk4.002682.00 | Activating signal cointegrator 1 complex subunit 3 |
Schmidtea mediterranea | mk4.002682.01 | |
Schmidtea mediterranea | mk4.018964.01 | |
Schmidtea mediterranea | mk4.043664.00 | Activating signal cointegrator 1 complex subunit 3 |
Schmidtea mediterranea | mk4.002244.00 | Putative U5 small nuclear ribonucleoprotein 200 kDa helicase |
Schmidtea mediterranea | mk4.002128.07 | |
Schmidtea mediterranea | mk4.018964.00 | |
Schmidtea mediterranea | mk4.004025.05 | |
Schmidtea mediterranea | mk4.013237.00 | Activating signal cointegrator 1 complex subunit 3 |
Trypanosoma brucei gambiense | Tbg972.11.5010 | ATP-dependent RNA helicase, putative,DEAD/DEAH box RNA helicase, putative |
Trypanosoma brucei gambiense | Tbg972.5.3230 | ATP-dependent RNA helicase, putative |
Trypanosoma brucei | Tb927.11.4380 | ATP-dependent RNA helicase, putative |
Trypanosoma brucei | Tb927.5.2290 | ATP-dependent RNA helicase, putative |
Trypanosoma congolense | TcIL3000.11.4440 | ATP-dependent RNA helicase, putative |
Trypanosoma cruzi | TcCLB.507663.50 | ATP-dependent RNA helicase, putative |
Trypanosoma cruzi | TcCLB.511315.9 | ATP-dependent RNA helicase, putative |
Trypanosoma cruzi | TcCLB.511755.60 | ATP-dependent RNA helicase, putative |
Trypanosoma cruzi | TcCLB.511313.40 | ATP-dependent RNA helicase, putative |
Toxoplasma gondii | TGME49_249810 | activating signal cointegrator 1 complex subunit 3, putative |
Toxoplasma gondii | TGME49_223390 | activating signal cointegrator 1 complex subunit 3 family 1 ASCC3L1, putative |
Theileria parva | TP03_0747 | ATP-dependent RNA helicase, putative |
Theileria parva | TP01_0582 | RNA helicase, putative |
Trichomonas vaginalis | TVAG_122950 | helicase, putative |
Trichomonas vaginalis | TVAG_485440 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_485450 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_552720 | activating signal cointegrator 1 complex subunit 3, helc1, putative |
Trichomonas vaginalis | TVAG_227750 | Antiviral helicase SLH1, putative |
Trichomonas vaginalis | TVAG_571910 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_584230 | activating signal cointegrator 1 complex subunit 3, helc1, putative |
Trichomonas vaginalis | TVAG_190620 | Antiviral helicase SLH1, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.2290 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.2290 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.2290 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.2290 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.02.1930 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.1930 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.1930 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.1930 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y46G5A.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y46G5A.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y46G5A.4 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y46G5A.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y46G5A.4 | Caenorhabditis elegans | sterile | wormbase |
YER172C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0522900 | Plasmodium berghei | Essential | plasmo |
PBANKA_1303000 | Plasmodium berghei | Dispensable | plasmo |
TGME49_223390 | Toxoplasma gondii | Probably essential | sidik |
TGME49_249810 | Toxoplasma gondii | Probably essential | sidik |
TGME49_223390 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_249810 | Toxoplasma gondii | Essentiality uncertain | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.