pI: 9.336 |
Length (AA): 514 |
MW (Da): 56759 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
14 | 301 | 5mf6 (A) | 14 | 297 | 42.00 | 0 | 1 | 1.06511 | -0.22 |
33 | 235 | 1yc5 (A) | 2 | 209 | 32.00 | 0 | 1 | 0.661242 | -0.01 |
37 | 255 | 1m2k (A) | 5 | 222 | 29.00 | 0 | 1 | 0.62637 | 0.05 |
48 | 134 | 4v1c (K) | 141 | 249 | 48.00 | 0.0017 | 0.92 | 0.257961 | 0.55 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_130121)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G55760 | sirtuin 1 |
Babesia bovis | BBOV_I003070 | transcriptional regulator, Sir2 family domain containing protein |
Brugia malayi | Bm1_16975 | transcriptional regulator, Sir2 family protein |
Caenorhabditis elegans | CELE_C06A5.11 | Protein SIR-2.4 |
Drosophila melanogaster | Dmel_CG6284 | CG6284 gene product from transcript CG6284-RB |
Echinococcus granulosus | EgrG_000908100 | NAD dependent deacetylase sirtuin 6 |
Echinococcus granulosus | EgrG_000908200 | alpha 12 mannosyltransferase Smp3 |
Echinococcus multilocularis | EmuJ_000908100 | NAD dependent deacetylase sirtuin 6 |
Echinococcus multilocularis | EmuJ_000908200 | alpha 1,2 mannosyltransferase Smp3 |
Homo sapiens | ENSG00000077463 | sirtuin 6 |
Loa Loa (eye worm) | LOAG_07562 | transcriptional regulator |
Mus musculus | ENSMUSG00000034748 | sirtuin 6 |
Neospora caninum | NCLIV_038820 | Sir2 domain-containing protein, putative |
Oryza sativa | 4335342 | Os04g0271000 |
Plasmodium berghei | PBANKA_1315100 | transcriptional regulatory protein sir2b |
Plasmodium falciparum | PF3D7_1451400 | transcriptional regulatory protein sir2b |
Plasmodium knowlesi | PKNH_1230700 | transcriptional regulatory protein sir2b, putative |
Plasmodium vivax | PVX_117910 | hypothetical protein, conserved |
Plasmodium yoelii | PY01626 | sir2-like protein |
Schistosoma japonicum | Sjp_0080320 | expressed protein |
Schistosoma japonicum | Sjp_0307950 | expressed protein |
Schistosoma japonicum | Sjp_0129710 | expressed protein |
Schistosoma japonicum | Sjp_0307780 | expressed protein |
Schistosoma japonicum | Sjp_0219540 | expressed protein |
Schistosoma japonicum | Sjp_0028930 | ko:K00775 NAD(P)-arginine ADP-ribosyltransferase [EC2.4.2.31], putative |
Schistosoma mansoni | Smp_134630 | chromatin regulatory protein sir2 |
Schmidtea mediterranea | mk4.000591.01 | NAD-dependent protein deacetylase sirtuin-6 |
Toxoplasma gondii | TGME49_267360 | histone deacetylase SIR2-like |
Theileria parva | TP01_0527 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1315100 | Plasmodium berghei | Dispensable | plasmo |
TGME49_267360 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_267360 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.