pI: 7.2662 |
Length (AA): 159 |
MW (Da): 17017 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
24 | 148 | 3lvl (A) | 2 | 126 | 77.00 | 0 | 1 | 1.79426 | -1.44 |
31 | 154 | 1wfz (A) | 5 | 128 | 80.00 | 0 | 1 | 1.77527 | -1.09 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127020)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G22220 | iron-sulfur cluster assembly protein 1 |
Arabidopsis thaliana | AT4G04080 | Iron-sulfur cluster assembly protein 3 |
Arabidopsis thaliana | AT3G01020 | iron-sulfur cluster assembly protein 2 |
Babesia bovis | BBOV_IV004050 | iron sulfur cluster assembly protein nifU-like, putative |
Brugia malayi | Bm1_36610 | NifU-like protein |
Candida albicans | CaO19.13901 | Iron-sulfur cluster nifU-like protein similar to S. cerevisiae ISU1 (YPL135W) mitochondrial iron-sulfur cluster assembly scaffol |
Candida albicans | CaO19.6548 | Iron-sulfur cluster nifU-like protein similar to S. cerevisiae ISU1 (YPL135W) mitochondrial iron-sulfur cluster assembly scaffol |
Candida albicans | CaO19_6548 | hypothetical protein |
Caenorhabditis elegans | CELE_Y45F10D.4 | Protein Y45F10D.4 |
Cryptosporidium hominis | Chro.60135 | IscU-like protein |
Cryptosporidium parvum | cgd6_1050 | IscU-like NifU protein, iron-sulfur protein |
Chlamydia trachomatis | CT_720 | NifU-like protein |
Dictyostelium discoideum | DDB_G0283003 | hypothetical protein |
Drosophila melanogaster | Dmel_CG9836 | CG9836 gene product from transcript CG9836-RA |
Escherichia coli | b2529 | iron-sulfur cluster assembly scaffold protein |
Echinococcus granulosus | EgrG_000483700 | iron sulfur cluster assembly enzyme ISCU |
Entamoeba histolytica | EHI_049620 | Fe-S cluster assembly protein NifU, putative |
Echinococcus multilocularis | EmuJ_000483700 | iron sulfur cluster assembly enzyme ISCU |
Giardia lamblia | GL50803_15196 | NifU-like protein |
Homo sapiens | ENSG00000136003 | iron-sulfur cluster assembly enzyme |
Leishmania braziliensis | LbrM.34.3580 | iron-sulfur cluster assembly protein, putative |
Leishmania donovani | LdBPK_353670.1 | iron-sulfur cluster assembly protein, putative |
Leishmania infantum | LinJ.35.3670 | iron-sulfur cluster assembly protein, putative |
Leishmania major | LmjF.35.3620 | iron-sulfur cluster assembly protein, putative |
Leishmania mexicana | LmxM.34.3620 | iron-sulfur cluster assembly protein, putative |
Loa Loa (eye worm) | LOAG_08352 | hypothetical protein |
Mycobacterium leprae | ML0597 | Possible nitrogen fixation related protein |
Mus musculus | ENSMUSG00000025825 | IscU iron-sulfur cluster scaffold homolog (E. coli) |
Mycobacterium tuberculosis | Rv1465 | Possible nitrogen fixation related protein |
Mycobacterium ulcerans | MUL_1866 | nitrogen fixation-like protein |
Neospora caninum | NCLIV_051300 | Nifu-pending protein, related |
Oryza sativa | 4339646 | Os05g0568100 |
Oryza sativa | 4327858 | Os01g0662600 |
Plasmodium berghei | PBANKA_1318200 | iron sulfur cluster assembly protein, putative |
Plasmodium falciparum | PF3D7_1454500 | iron sulfur cluster assembly protein, putative |
Plasmodium knowlesi | PKNH_1227600 | iron sulfur cluster assembly protein, putative |
Plasmodium vivax | PVX_117755 | nifU protein, putative |
Plasmodium yoelii | PY00856 | NifU-like N terminal domain, putative |
Saccharomyces cerevisiae | YOR226C | putative iron-binding protein ISU2 |
Saccharomyces cerevisiae | YPL135W | iron-binding protein ISU1 |
Schistosoma japonicum | Sjp_0006260 | ko:K04488 nitrogen fixation protein NifU and related proteins, putative |
Schistosoma mansoni | Smp_077090 | nitrogen fixation protein nifu |
Schmidtea mediterranea | mk4.000914.06 | Iron-sulfur cluster assembly enzyme ISCU, mitochondrial |
Schmidtea mediterranea | mk4.000455.02 | Putative nitrogen fixation protein nifu |
Trypanosoma brucei gambiense | Tbg972.9.6980 | iron-sulfur cluster assembly protein, putative |
Trypanosoma brucei | Tb927.9.11720 | Iron-sulfur cluster assembly protein |
Trypanosoma congolense | TcIL3000_9_4750 | Iron-sulfur cluster assembly protein |
Trypanosoma cruzi | TcCLB.510667.70 | iron-sulfur cluster assembly protein, putative |
Trypanosoma cruzi | TcCLB.507009.90 | iron-sulfur cluster assembly protein, putative |
Toxoplasma gondii | TGME49_237560 | iron-sulfur cluster protein ISCU |
Treponema pallidum | TP0615 | nitrogen fixation protein (nifU) |
Theileria parva | TP01_0192 | NifU protein, putative |
Trichomonas vaginalis | TVAG_432650 | nitrogen fixation protein nifu, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0756 | scaffold protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.211.2830 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.2830 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.2830 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.211.2830 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2529 | Escherichia coli | essential | goodall |
CELE_Y45F10D.4 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_Y45F10D.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y45F10D.4 | Caenorhabditis elegans | larval arrest | wormbase |
PBANKA_1318200 | Plasmodium berghei | Essential | plasmo |
TGME49_237560 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.