pI: 6.6461 |
Length (AA): 1278 |
MW (Da): 140012 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 199 | 5t89 (X) | 406 | 641 | 28.00 | 0.0099 | 0.14 | 0.0314121 | 1.66 |
19 | 528 | 3dmk (A) | 201 | 680 | 28.00 | 0 | 1 | 0.428761 | 1.38 |
131 | 212 | 3ncm (A) | 8 | 90 | 22.00 | 0 | 0.72 | 0.279463 | -0.85 |
132 | 203 | 1u2h (A) | 27 | 102 | 32.00 | 0.42 | 0.71 | 0.385038 | -0.5 |
136 | 213 | 5fm5 (O) | 257 | 337 | 37.00 | 0.42 | 0.99 | 0.469733 | -0.62 |
218 | 897 | 4yh7 (A) | 32 | 608 | 25.00 | 0.0000000000066 | 1 | 0.399781 | 1.8 |
220 | 301 | 1pew (A) | 4 | 108 | 29.00 | 0 | 1 | 0.207463 | -1.33 |
231 | 288 | 1gl4 (B) | 1785 | 1843 | 45.00 | 0.0091 | 1 | 0.546083 | -1.03 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128686)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_06225 | Immunoglobulin I-set domain containing protein |
Brugia malayi | Bm1_06230 | Immunoglobulin I-set domain containing protein |
Caenorhabditis elegans | CELE_ZK377.2 | Protein SAX-3, isoform A |
Drosophila melanogaster | Dmel_CG5481 | leak |
Drosophila melanogaster | Dmel_CG13521 | roundabout |
Drosophila melanogaster | Dmel_CG5423 | CG5423 gene product from transcript CG5423-RB |
Echinococcus granulosus | EgrG_000805500 | roundabout 2 |
Echinococcus granulosus | EgrG_000748500 | roundabout 2 |
Echinococcus granulosus | EgrG_000992700 | roundabout 2 |
Echinococcus multilocularis | EmuJ_000805500 | roundabout 2 |
Echinococcus multilocularis | EmuJ_000992700 | roundabout 2 |
Echinococcus multilocularis | EmuJ_000748500 | roundabout 2 |
Homo sapiens | ENSG00000154134 | roundabout, axon guidance receptor, homolog 3 (Drosophila) |
Homo sapiens | ENSG00000185008 | roundabout, axon guidance receptor, homolog 2 (Drosophila) |
Homo sapiens | ENSG00000169855 | roundabout, axon guidance receptor, homolog 1 (Drosophila) |
Loa Loa (eye worm) | LOAG_09203 | immunoglobulin I-set domain-containing protein |
Loa Loa (eye worm) | LOAG_07032 | immunoglobulin I-set domain-containing protein |
Mus musculus | ENSMUSG00000022883 | roundabout homolog 1 (Drosophila) |
Mus musculus | ENSMUSG00000052516 | roundabout homolog 2 (Drosophila) |
Mus musculus | ENSMUSG00000032128 | roundabout homolog 3 (Drosophila) |
Onchocerca volvulus | OVOC5391 |
|
Schistosoma japonicum | Sjp_0012540 | expressed protein |
Schistosoma japonicum | Sjp_0024780 | Roundabout homolog 2 precursor, putative |
Schistosoma japonicum | Sjp_0012550 | Roundabout homolog 2 precursor, putative |
Schistosoma japonicum | Sjp_0118600 | expressed protein |
Schistosoma japonicum | Sjp_0055180 | ko:K06754 roundabout, axon guidance receptor 2, putative |
Schistosoma japonicum | Sjp_0103280 | Roundabout homolog 2 precursor, putative |
Schistosoma mansoni | Smp_173100 | roundabout |
Schistosoma mansoni | Smp_024660 | cell adhesion molecule |
Schmidtea mediterranea | mk4.015944.00 | |
Schmidtea mediterranea | mk4.006497.00 | RoboA |
Schmidtea mediterranea | mk4.007418.00 | |
Schmidtea mediterranea | mk4.019809.00 | |
Schmidtea mediterranea | mk4.000335.02 | |
Schmidtea mediterranea | mk4.013350.00 | |
Schmidtea mediterranea | mk4.019809.01 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.