pI: 9.4934 |
Length (AA): 276 |
MW (Da): 31936 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_129297)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G72590 | 3-oxo-5-alpha-steroid 4-dehydrogenase family protein |
Arabidopsis thaliana | AT2G16530 | putative polyprenol reductase 2 |
Candida albicans | CaO19.7841 | possible transmembrane steroid 5-alpha-reductase similar to S. cerevisiae DFG10 (YIL049W) |
Candida albicans | CaO19.209 | possible transmembrane steroid 5-alpha-reductase similar to S. cerevisiae DFG10 (YIL049W) |
Caenorhabditis elegans | CELE_B0024.13 | Protein B0024.13 |
Cryptosporidium hominis | Chro.50250 | similar to NC_001141 protein required for filamentous growth, cell polarity, and cellular elongation |
Cryptosporidium parvum | cgd5_1340 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0284423 | hypothetical protein |
Drosophila melanogaster | Dmel_CG7840 | CG7840 gene product from transcript CG7840-RA |
Echinococcus granulosus | EgrG_000674800 | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal |
Echinococcus multilocularis | EmuJ_000674800 | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal |
Homo sapiens | ENSG00000128039 | steroid 5 alpha-reductase 3 |
Loa Loa (eye worm) | LOAG_12238 | hypothetical protein |
Mus musculus | ENSMUSG00000029233 | steroid 5 alpha-reductase 3 |
Neospora caninum | NCLIV_035090 | 3-oxo-5-alpha-steroid 4-dehydrogenase family protein, related |
Oryza sativa | 4343281 | Os07g0493400 |
Oryza sativa | 4336740 | Os04g0576800 |
Onchocerca volvulus | OVOC11276 |
|
Plasmodium berghei | PBANKA_1319600 | polyprenol reductase, putative |
Plasmodium falciparum | PF3D7_1455900 | polyprenol reductase, putative |
Plasmodium knowlesi | PKNH_1225900 | polyprenol reductase, putative |
Plasmodium vivax | PVX_117670 | polyprenol reductase, putative |
Plasmodium yoelii | PY01579 | dfg10 protein |
Saccharomyces cerevisiae | YIL049W | Dfg10p |
Toxoplasma gondii | TGME49_272180 | 3-oxo-5-alpha-steroid 4-dehydrogenase |
Theileria parva | TP04_0208 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1319600 | Plasmodium berghei | Essential | plasmo |
TGME49_272180 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.