Detailed view for EmuJ_000111600

Basic information

TDR Targets ID: 965286
Echinococcus multilocularis, solute carrier family 28
Source Database / ID:  GeneDB

pI: 7.8939 | Length (AA): 694 | MW (Da): 77219 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 12

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01773   Na+ dependent nucleoside transporter N-terminus
PF07662   Na+ dependent nucleoside transporter C-terminus

Gene Ontology

Mouse over links to read term descriptions.
GO:1901642   GO:nucleoside transmembrane transport  

GO:0016020   membrane  
GO:0005337   nucleoside transmembrane transporter activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
248 693 5l26 (A) 0 419 31.00 0 1 0.938051 -0.13
253 689 4pd6 (A) 5 415 34.00 0 1 0.907983 0.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127724)

Species Accession Gene Product
Candida albicans CaO19.11600   potential Na+-dependent nucleoside transporter
Candida albicans CaO19.4118   potential Na+-dependent nucleoside transporter
Caenorhabditis elegans CELE_F27E11.1   Protein F27E11.1
Caenorhabditis elegans CELE_F27E11.2   Protein F27E11.2, isoform A
Drosophila melanogaster Dmel_CG8083   CG8083 gene product from transcript CG8083-RA
Drosophila melanogaster Dmel_CG11778   Concentrative Nucleoside Transporter 1
Escherichia coli b2164   putative nucleoside transporter
Escherichia coli b2393   nucleoside (except guanosine) transporter
Escherichia coli b2161   nucleoside permease
Echinococcus granulosus EgrG_000127300   Na+ dependent nucleoside transporter
Echinococcus granulosus EgrG_000127200   concentrative Na nucleoside cotransporter
Echinococcus granulosus EgrG_000111600   solute carrier family 28
Echinococcus multilocularis EmuJ_000127200   concentrative Na+ nucleoside cotransporter
Echinococcus multilocularis EmuJ_000127300   sodium:nucleoside cotransporter 2
Echinococcus multilocularis EmuJ_000111600   solute carrier family 28
Homo sapiens ENSG00000156222   solute carrier family 28 (concentrative nucleoside transporter), member 1
Homo sapiens 9153   solute carrier family 28 (concentrative nucleoside transporter), member 2
Homo sapiens ENSG00000197506   solute carrier family 28 (concentrative nucleoside transporter), member 3
Mus musculus ENSMUSG00000079071   predicted gene 14085
Mus musculus ENSMUSG00000025726   solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
Mus musculus ENSMUSG00000021553   solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
Mus musculus ENSMUSG00000027219   solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
Schmidtea mediterranea mk4.003282.00  
Schmidtea mediterranea mk4.006256.01  
Schmidtea mediterranea mk4.008060.01  

Essentiality

EmuJ_000111600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2161 Escherichia coli non-essential goodall
b2164 Escherichia coli non-essential goodall
b2393 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens solute carrier family 28 (concentrative nucleoside transporter), member 3 Compounds References
Homo sapiens solute carrier family 28 (concentrative nucleoside transporter), member 2 Compounds References
Rattus norvegicus Sodium/nucleoside cotransporter 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0376 0.452 0.452
0.3545 1 1
0.0338 1 1
0.0355 0.2526 0.2524
0.0333 0.4723 0.7328
0.0336 0.4175 0.4169
0.0351 0.2589 0.2864
0.0367 0.4906 1
0.0318516 0.277126 0.293048
0.261 1 1
0.355 1 1
0.0504 0.51 0.51
0.0364 1 1
0.0504 0.5076 0.5076
0.0344 0.2601 0.4139
0.4319 1 1
0.0346 1 1
0.0335 1 1
0.2897 1 1
0.1225 1 1
0.0351 0.2612 0.2872
0.0338997 0.305913 1
0.0342 0.4167 0.4166
0.0339 1 1
0.0353 0.3502 0.3486
0.0353 1 1
0.0336 0.4169 0.4169
0.0336 0.3039 0.3039
0.0505 0.4695 0.4695
0.0318516 0.277126 0.293048
0.1559 0.6306 0.6306
0.0326513 1 1
0.0337 0.6254 0.557
0.0348 0.2526 0.2839
0.3761 1 1
0.0338 0.6574 0.6486
0.4046 0.6974 0.6974
0.0335 0.3616 0.3616
0.0337 0.4166 0.4166
0.0357 0.2645 0.3821
0.0356 1 1
0.0321735 1 1
0.0345 0.2708 0.2708
0.0347 0.4169 0.4169
0.0336 0.6537 0.6526
0.0415 1 1
0.0339 0.417 0.417
0.0351 0.7276 0.9899
0.1576 1 1
0.0345 0.2517 0.2517
0.0372 0.5388 0.5388
0.0338 0.2575 0.2778
0.0336 0.3039 0.3039
0.0341 0.4156 0.4156
0.0339 0.283 0.2806
0.0207 1 1
0.0167 0.7425 1
0.0344 0.341 0.4196
0.3362 1 1
0.2732 1 1
0.3659 1 1
0.0342 0.6561 0.6477
0.0347 0.415 0.415
0.0171 0.3268 0.3315
0.4046 0.6974 0.6974
0.1225 1 1
0.0346 0.2645 0.345
0.0168 0.9898 1
0.0341 0.4166 0.4166
0.2549 1 1
0.3966 1 1
0.4046 0.6974 0.6974
0.0344 0.3842 0.3842
0.4046 0.6974 0.6974
0.1567 1 1
0.122 0.8355 0.8355
0.0502 0.5717 0.5717
0.0341 0.4147 0.4147
0.037 0.6715 0.6715
0.0348 0.4162 0.4162
0.034 0.2536 0.2536
0.3843 1 1
0.0333 1 1
0.0846 0.3382 0.3382
0.17 1 1
0.1943 1 1
0.0338 0.4096 0.4096
0.0332 0.4159 0.4159
0.0396 0.2747 0.2747
0.0341 0.2664 0.2625
0.0326513 1 1
0.0342 0.415 0.415
0.0339 0.6544 0.6542
0.1752 0.5992 0.8099
0.3487 1 1
0.3855 1 1
0.0353 0.5147 0.5116
0.0338 0.6762 1
0.0341 0.4166 0.4166
0.2562 1 1
0.237 1 1
0.0333 0.9837 0.9837
0.1198 1 1
0.0351 0.4166 0.4166
0.1416 0.3387 1
0.0345 0.2708 0.2708
0.0333 1 1
0.0346324 0.315651 1
0.0346 0.3076 1
0.0358 0.2641 0.4138
0.036 0.6918 0.7091
0.0359 0.7382 0.9994
0.0333 0.6761 1
0.0207 1 1
0.0338 0.4141 0.4139
0.0336 0.3377 0.3376
0.0336879 0.299611 1
0.0348 1 1
0.0359 0.2601 0.2954
0.0859 1 1
0.0509 0.516 0.516
0.0333 0.6369 0.6353
0.0207 1 1
0.0338 0.3377 0.3377
0.0346 0.2533 0.3195
0.4046 0.6974 0.6974
0.0367 1 1
0.2562 1 1
0.0207 1 1
0.0343 0.4162 0.4162
0.0333 0.334 0.334
0.1352 1 1
0.0348 1 1
0.0354 0.2608 0.2912
0.3659 1 1
0.0343 0.3615 0.3615
0.0333 0.9208 0.9208
0.1704 1 1
0.1567 0.9865 0.9865
0.0333 0.4723 0.7328
0.1559 0.361 0.361
0.1559 0.361 0.361
0.0346 0.3611 0.3602
0.0347 0.4169 0.4169
0.3734 1 1
0.3387 1 1
0.0336 0.5926 0.5668
0.1559 0.361 0.361
0.0344 0.2864 0.3204
0.0346 0.2774 0.3042
0.0346 1 1
0.1531 1 1
0.0367 0.8689 0.8615
0.0505 1 1
0.0340473 0.297507 0.351303
0.0346 1 1
0.3587 1 1
0.2279 1 1
0.4046 0.6974 0.6974
0.4046 0.6974 0.6974
0.0175 0.5241 0.5241
0.0713 0.2861 0.2842
0.0339 0.6544 0.6542
0.0352 0.388 0.6217
0.0349 0.6204 0.6204
0.0385 0.2681 0.2675
0.0341 0.4147 0.4147
0.0351 0.2534 0.2858
0.0389 0.2754 0.2744
0.0339 0.4169 0.4169
0.0335 0.3325 0.3309
0.424 1 1
0.0351 0.2612 0.2872
0.4323 1 1
0.0361 0.5622 0.5598
0.0345 1 1
0.0338 1 1
0.1389 1 1
0.0352 0.388 0.6217
0.0334 0.4127 0.4126
0.2651 1 1
0.0337 0.4166 0.4166
0.173 1 1
0.0338997 0.305913 1
0.0348 0.3494 0.3489
0.4194 1 1
0.0367 1 1
0.1198 1 1
0.0396 0.2764 0.2764
0.0345 0.6798 0.6915
0.035 0.562 0.5615
0.0357 0.2645 0.3796
0.0339 0.62 0.62
0.3659 1 1
0.0352 0.2644 0.2815
0.0341 0.6691 0.6834
0.0343 0.4166 0.4166
0.0359 0.2681 0.4148
0.1559 0.361 0.361
0.0339 1 1
0.0675 0.2711 0.2711
0.0341 0.4147 0.4147
0.0335 0.4039 0.6233
0.034 0.415 0.415
0.3387 1 1
0.0207 1 1
0.3487 1 1
0.0344 0.2601 0.4139
0.0403 0.2735 0.2735
0.0386 0.2743 0.2743
0.3487 1 1
0.0355 1 1
0.1235 1 1
0.1747 1 1
0.0339 0.4167 0.4166
0.1257 1 1
0.0344 0.341 0.4196
0.0357 0.3426 0.4892
0.0353 0.3491 0.3491
0.0521 1 1
0.4262 1 1
0.034 0.3739 0.3739
0.0348 0.4141 0.4139
0.0333 0.4167 0.4166
0.0407 0.2703 0.2703
0.122732 1 1
0.0344 0.2641 0.4144
0.1752 0.5992 0.8099
0.0334 0.3371 0.337
0.3855 1 1
0.1215 1 1
0.0351 0.2589 0.2864
0.1588 0.981 0.981
0.0367 0.8772 0.9022
0.0335 0.8991 1
0.0354 0.4166 0.4166
0.0389 0.2766 0.2766
0.0341 0.4169 0.4169
0.0346 0.4149 0.4147
0.0348 0.265 0.4155
0.3855 1 1
0.0351 1 1
0.1198 1 1
0.0365 0.3405 0.377
0.4189 1 1
0.0343 0.4162 0.4162
0.0335 0.4039 0.6233
0.034 0.415 0.415
0.3855 1 1
0.0338 0.4169 0.4169
0.0339 0.4326 1
0.0333 1 1
0.0207 1 1
0.3387 1 1
0.0343 0.3203 0.3203
0.0337 0.3009 1
0.0361 1 1
0.0361 1 1
0.0355 0.4156 0.4156
0.1202 1 1
0.1239 1 1
0.1288 1 1
0.0358 0.5241 0.5241
0.0332 0.4159 0.4159
0.0335 0.4039 0.6233
0.0396 0.2747 0.2747
0.0207 1 1
0.0207 1 1
0.2551 1 1
0.0332 0.398 0.398
0.0318516 0.277126 0.293048
0.1581 0.9828 0.9828
0.0352 0.4514 0.4926
0.1352 1 1
0.0348 0.2526 0.2839
0.0340961 1 1
0.3298 1 1
0.0361 1 1
0.0346324 0.315651 1
0.3917 1 1
0.4093 1 1
0.0318516 0.277126 0.293048
0.0346 0.2645 0.345
0.3362 1 1
0.0719 0.2543 0.2522
0.0336 0.378 0.378
0.0389 0.2681 0.2681
0.0326315 1 1
0.0346 0.7678 0.7678
0.0396 0.2747 0.2747
0.0207 1 1
0.034 0.2555 0.2555
0.0341 0.3185 0.4418
0.0379 0.4529 0.4529
0.0335 0.4039 0.6233
0.0343 0.4149 0.4147
0.4206 1 1
0.0345 0.2708 0.2708
0.0341 0.4179 0.4179
0.035 0.2543 0.2543
0.034 0.5296 0.5292
0.3843 1 1
0.0343 0.4169 0.4169
0.0338 0.3101 0.6195
0.0333 0.4176 0.4169
0.0332 0.398 0.398
0.0333 0.4167 0.4166
0.1559 0.6306 0.6306
0.3545 1 1
0.0855 1 1
0.0354 0.2608 0.2912
0.385 1 1
0.0326513 1 1
0.0348 0.2534 0.3228
0.0357 0.3426 0.4892
0.04 0.2758 0.2749
0.0346 0.2645 0.345
0.0367 1 1
0.0367 0.4527 0.4527
0.0357 0.3453 0.4949

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EmuJ_000111600 (Echinococcus multilocularis), solute carrier family 28
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