Detailed view for EmuJ_000583800

Basic information

TDR Targets ID: 965740
Echinococcus multilocularis, aldehyde dehydrogenase family 3 member B1
Source Database / ID:  GeneDB

pI: 8.0213 | Length (AA): 336 | MW (Da): 37612 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00171   Aldehyde dehydrogenase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016620   oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor  
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 310 5ucd (A) 127 432 35.00 0 1 1.35882 -0.17
1 332 5myp (A) 135 481 37.00 0 1 1.3884 0.01
3 332 4qgk (A) 121 447 39.00 0 1 1.45144 0.02
3 328 1ad3 (A) 123 445 39.00 0 1 1.44544 -0.06

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127094)

Species Accession Gene Product
Arabidopsis thaliana AT1G44170   aldehyde dehydrogenase 3H1
Arabidopsis thaliana AT4G34240   aldehyde dehydrogenase 3I1
Brugia malayi Bm1_51685   Aldehyde dehydrogenase protein 4
Candida albicans CaO19_6518   hypothetical protein
Candida albicans CaO19.13487   similar to aldehyde dehydrogenases
Candida albicans CaO19.6518   similar to aldehyde dehydrogenases
Candida albicans CaO19.13871   similar to aldehyde dehydrogenases
Candida albicans CaO19.6066   similar to aldehyde dehydrogenases
Caenorhabditis elegans CELE_T08B1.3   Protein ALH-5
Caenorhabditis elegans CELE_T05H4.13   Protein ALH-4, isoform C
Dictyostelium discoideum DDB_G0292270   aldehyde dehydrogenase
Drosophila melanogaster Dmel_CG11140   Aldehyde dehydrogenase type III
Echinococcus granulosus EgrG_001100700   ras gtp binding protein rho1
Echinococcus granulosus EgrG_000583800   aldehyde dehydrogenase family 3 member B1
Echinococcus granulosus EgrG_000608100   Fatty aldehyde dehydrogenase
Entamoeba histolytica EHI_042140   aldehyde dehydrogenase 1, putative
Echinococcus multilocularis EmuJ_000583800   aldehyde dehydrogenase family 3 member B1
Echinococcus multilocularis EmuJ_001100700   ras gtp binding protein rho1
Echinococcus multilocularis EmuJ_000608100   Fatty aldehyde dehydrogenase
Homo sapiens ENSG00000108602   aldehyde dehydrogenase 3 family, member A1
Homo sapiens ENSG00000132746   aldehyde dehydrogenase 3 family, member B2
Homo sapiens ENSG00000072210   aldehyde dehydrogenase 3 family, member A2
Homo sapiens ENSG00000006534   aldehyde dehydrogenase 3 family, member B1
Loa Loa (eye worm) LOAG_07638   aldehyde dehydrogenase 4
Mycobacterium leprae ML2639c   PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT
Mus musculus ENSMUSG00000019102   aldehyde dehydrogenase family 3, subfamily A1
Mus musculus ENSMUSG00000075296   aldehyde dehydrogenase 3 family, member B2
Mus musculus ENSMUSG00000010025   aldehyde dehydrogenase family 3, subfamily A2
Mus musculus 102643082   aldehyde dehydrogenase family 3 member B1-like
Mus musculus 73458   RIKEN cDNA 1700055N04 gene
Mus musculus ENSMUSG00000024885   aldehyde dehydrogenase 3 family, member B1
Mycobacterium tuberculosis Rv0147   Probable aldehyde dehydrogenase (NAD+) dependent
Mycobacterium ulcerans MUL_4760   aldehyde dehydrogenase (NAD+) dependent
Oryza sativa 4349966   Os11g0186200
Onchocerca volvulus OVOC6843   Aldehyde dehydrogenase homolog
Saccharomyces cerevisiae YMR110C   Hfd1p
Schistosoma japonicum Sjp_0057270   ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative
Schistosoma japonicum Sjp_0207190   Rho-related GTP-binding protein RhoC precursor, putative
Schistosoma mansoni Smp_172730   aldehyde dehydrogenase
Schmidtea mediterranea mk4.002506.03   Putative aldehyde dehydrogenase
Schmidtea mediterranea mk4.046047.00  
Trypanosoma brucei gambiense Tbg972.6.2840   aldehyde dehydrogenase family, putative
Trypanosoma brucei Tb927.6.3050   aldehyde dehydrogenase family, putative
Trypanosoma congolense TcIL3000_6_2570   aldehyde dehydrogenase family, putative
Trypanosoma congolense TcIL3000_0_08790   aldehyde dehydrogenase family, putative
Trypanosoma cruzi TcCLB.507023.120   aldehyde dehydrogenase family, putative
Trypanosoma cruzi TcCLB.511751.120   aldehyde dehydrogenase family, putative
Trichomonas vaginalis TVAG_346790   succinate semialdehyde dehydrogenase, putative

Essentiality

EmuJ_000583800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu148 Mycobacterium tuberculosis non-essential nmpdr
Tb927.6.3050 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.3050 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.3050 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.6.3050 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T05H4.13 Caenorhabditis elegans adult lethal wormbase
CELE_T05H4.13 Caenorhabditis elegans embryonic lethal wormbase
CELE_T05H4.13 Caenorhabditis elegans larval lethal wormbase
CELE_T05H4.13 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens aldehyde dehydrogenase 3 family, member A1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0154 0.5743 0.8739
0.0232 0.3384 0.3384
0.003 1 1
0.0164 1 1
0.0128 0.4896 1
0.0232 0.3384 0.3384
0.0154 0.5743 0.8739
0.02 1 1
0.0161 0.3569 0.9627
0.0128 0.4896 1
0.0029 0.5903 0.5815
0.0232 0.3384 0.3384
0.0025 1 1
0.003 0.3003 0.3003
0.003 0.3003 0.3003
0.0232 0.3384 0.3384
0.0232 0.3384 0.3384
0.0232 0.3384 0.3384

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EmuJ_000583800 (Echinococcus multilocularis), aldehyde dehydrogenase family 3 member B1
Title for this comment
Comment