Detailed view for EmuJ_000422300

Basic information

TDR Targets ID: 965873
Echinococcus multilocularis, hemicentin 1
Source Database / ID:  GeneDB

pI: 5.4439 | Length (AA): 2521 | MW (Da): 276888 | Paralog Number: 5

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00090   Thrombospondin type 1 domain
PF07474   G2F domain
PF07645   Calcium-binding EGF domain
PF07679   Immunoglobulin I-set domain
PF12662   Complement Clr-like EGF-like
PF13927   Immunoglobulin domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005509   calcium ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 26 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 66 5uv6 (A) 113 171 29.00 0.016 0.05 0.0121901 1.67
26 412 3kld (A) 24 391 29.00 0 1 0.128111 1.21
28 109 1u2h (A) 19 100 38.00 0.00026 1 0.474127 -0.66
47 112 3puc (A) 22 89 44.00 0.00026 1 0.54178 -0.9
130 714 5oj2 (A) 45 616 28.00 0 1 0.216651 1.51
140 217 5fm5 (O) 260 339 40.00 0.00089 0.99 0.49554 -0.9
330 908 3b43 (A) 1 565 29.00 0 1 0.325271 1.2
447 1171 3dmk (A) 24 762 26.00 0 1 0.352184 1.21
727 814 5xnp (A) 286 374 35.00 0.0002 0.98 0.528507 -1.1
742 1264 5t89 (X) 46 647 27.00 0.0000000000066 1 0.177057 1.46
964 1296 5d4k (A) 71 464 26.00 0.17 0.75 0.0226904 1.4
1003 1355 5ope (A) 67 439 29.00 0 1 0.321624 0.94
1017 1076 4c4k (O) 24 84 47.00 0.0036 1 0.5304 -0.71
1096 1351 4u7m (A) 495 770 30.00 0 1 0.305147 0.72
1185 1275 2cqv (A) 8 101 27.00 0.015 1 0.414697 -0.93
1185 1258 2lvc (A) 9 81 34.00 0.093 1 0.357953 -0.13
1200 1364 2iep (A) 43 210 35.00 0.0000000000066 1 0.42205 -0.01
1206 1344 2xy2 (A) 42 186 34.00 0.000000047 1 0.358737 0.32
1274 1352 2dm3 (A) 9 91 35.00 0.00007 0.69 0.353937 -0.08
1275 1362 3zyj (A) 354 443 31.00 0.53 1 0.399507 -0.69
1366 1471 1lsl (A) 418 523 53.00 0 1 0.604647 0.13
1481 1594 1lsl (A) 418 528 50.00 0 1 0.42502 -0.09
2027 2074 3f1s (B) 87 134 38.00 0.021 1 0.54464 -1
2029 2270 4xbm (B) 221 425 35.00 0.000000015 1 0.0165937 1.55
2037 2436 1n7d (A) 74 462 28.00 0.0000000007 0.75 -0.0437328 2.53
2115 2152 5cis (A) 118 157 55.00 0.018 0.66 0.560673 0.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126738)

Species Accession Gene Product
Brugia malayi Bm1_26690   Prion-like-
Brugia malayi Bm1_54260   Prion-like-
Brugia malayi Bm1_02325   Immunoglobulin I-set domain containing protein
Brugia malayi Bm1_17625   muscle M-line assembly protein unc-89
Brugia malayi Bm1_39425   protein unc-22
Brugia malayi Bm1_55550   kettin
Brugia malayi Bm1_12515   Immunoglobulin I-set domain containing protein
Caenorhabditis elegans CELE_F54E2.4   Protein F54E2.4
Caenorhabditis elegans CELE_C09D1.1   Protein UNC-89, isoform B
Caenorhabditis elegans CELE_F15G9.4   Protein HIM-4, isoform D
Caenorhabditis elegans CELE_F54E2.3   Protein KETN-1, isoform C
Caenorhabditis elegans CELE_ZK617.1   Protein UNC-22, isoform F
Caenorhabditis elegans CELE_F15G9.4a   Protein HIM-4, isoform C
Dictyostelium discoideum DDB_G0294611   hypothetical protein
Drosophila melanogaster Dmel_CG1915   sallimus
Drosophila melanogaster Dmel_CG42768   Muscle-specific protein 300 kDa
Drosophila melanogaster Dmel_CG32019   bent
Drosophila melanogaster Dmel_CG33519   CG33519 gene product from transcript CG33519-RH
Echinococcus granulosus EgrG_000597700   titin
Echinococcus granulosus EgrG_000952600   titin
Echinococcus granulosus EgrG_000422350   hemicentin 1
Echinococcus granulosus EgrG_000226000   titin
Echinococcus multilocularis EmuJ_000422400   hemicentin 1
Echinococcus multilocularis EmuJ_000597700   titin
Echinococcus multilocularis EmuJ_000226000   titin
Echinococcus multilocularis EmuJ_000952600  
Echinococcus multilocularis EmuJ_000039200   titin
Echinococcus multilocularis EmuJ_000422300   hemicentin 1
Homo sapiens 101930376   hemicentin-2-like
Homo sapiens ENSG00000143341   hemicentin 1
Homo sapiens ENSG00000124006   obscurin-like 1
Homo sapiens ENSG00000155657   titin
Homo sapiens ENSG00000148357   hemicentin 2
Homo sapiens ENSG00000072195   SPEG complex locus
Homo sapiens ENSG00000154358   obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Homo sapiens ENSG00000072195   CAVP-target protein-like
Homo sapiens 101929220   WAS/WASL-interacting protein family member 1-like
Loa Loa (eye worm) LOAG_01020   hypothetical protein
Loa Loa (eye worm) LOAG_04436   hypothetical protein
Loa Loa (eye worm) LOAG_01021   hypothetical protein
Loa Loa (eye worm) LOAG_15451   hypothetical protein
Loa Loa (eye worm) LOAG_04544   hypothetical protein
Loa Loa (eye worm) LOAG_01925   CAMK/MLCK protein kinase
Loa Loa (eye worm) LOAG_05722   hypothetical protein
Loa Loa (eye worm) LOAG_15557   hypothetical protein
Loa Loa (eye worm) LOAG_02065   hypothetical protein
Loa Loa (eye worm) LOAG_09000   projectin
Loa Loa (eye worm) LOAG_04438   hypothetical protein
Loa Loa (eye worm) LOAG_07554   hypothetical protein
Loa Loa (eye worm) LOAG_07292   hypothetical protein
Loa Loa (eye worm) LOAG_04081   hypothetical protein
Loa Loa (eye worm) LOAG_02063   hypothetical protein
Loa Loa (eye worm) LOAG_02064   hypothetical protein
Mus musculus ENSMUSG00000061462   obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Mus musculus ENSMUSG00000055632   hemicentin 2
Mus musculus ENSMUSG00000066842   hemicentin 1
Mus musculus 102641264   titin-like
Mus musculus ENSMUSG00000051747   titin
Mus musculus ENSMUSG00000026211   obscurin-like 1
Mus musculus ENSMUSG00000026207   SPEG complex locus
Neospora caninum NCLIV_040610   Virulent strain associated lipoprotein, related
Onchocerca volvulus OVOC3498   Putative titin
Onchocerca volvulus OVOC7179  
Schistosoma japonicum Sjp_0109770   IPR013098,Immunoglobulin I-set,domain-containing
Schistosoma japonicum Sjp_0134570   IPR000215,Proteinase inhibitor I4, serpin,domain-containing
Schistosoma japonicum Sjp_0208700   ko:K00907 myosin-light-chain kinase [EC2.7.11.18], putative
Schistosoma japonicum Sjp_0098070   Titin, putative
Schistosoma japonicum Sjp_0115810   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0056280   ko:K06841 semaphorin 5, putative
Schistosoma japonicum Sjp_0094680   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0011210   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0097290   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0308120   IPR007110,Immunoglobulin-like,domain-containing
Schistosoma japonicum Sjp_0097890   ko:K00907 myosin-light-chain kinase [EC2.7.11.18], putative
Schistosoma japonicum Sjp_0094690   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0104450   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0088120   IPR013098,Immunoglobulin I-set;IPR003599,Immunoglobulin subtype;IPR007110,Immunoglobulin-like,domain-containing
Schistosoma mansoni Smp_126240   titin
Schistosoma mansoni Smp_157010   titin
Schistosoma mansoni Smp_105020   titin
Schistosoma mansoni Smp_157020   hemicentin
Schistosoma mansoni Smp_163920   titin
Schmidtea mediterranea mk4.000677.06  
Schmidtea mediterranea mk4.003018.00  
Schmidtea mediterranea mk4.000643.04  
Schmidtea mediterranea mk4.001029.10  
Schmidtea mediterranea mk4.000677.07  
Schmidtea mediterranea mk4.030799.00  
Schmidtea mediterranea mk4.000677.05  
Schmidtea mediterranea mk4.000643.06  
Schmidtea mediterranea mk4.000677.08   Twitchin
Schmidtea mediterranea mk4.001095.04  
Schmidtea mediterranea mk4.001029.07   Putative titin
Schmidtea mediterranea mk4.000677.04  
Schmidtea mediterranea mk4.007460.00  
Schmidtea mediterranea mk4.000677.03  
Schmidtea mediterranea mk4.001029.09  
Schmidtea mediterranea mk4.008079.00  
Schmidtea mediterranea mk4.000643.03  
Schmidtea mediterranea mk4.020649.02  
Schmidtea mediterranea mk4.001519.04  
Schmidtea mediterranea mk4.007626.00   Kettin/titin-related protein
Schmidtea mediterranea mk4.001252.09  
Schmidtea mediterranea mk4.003939.00  
Schmidtea mediterranea mk4.006111.00  
Schmidtea mediterranea mk4.001519.01   Putative titin
Schmidtea mediterranea mk4.014446.03  
Schmidtea mediterranea mk4.001029.11  
Schmidtea mediterranea mk4.000643.05   Putative titin

Essentiality

EmuJ_000422300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F54E2.3 Caenorhabditis elegans slow growth wormbase
CELE_ZK617.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZK617.1 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Homo sapiens High affinity immunoglobulin gamma Fc receptor I 374 aa 20.9% 325 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.004 0.2952 0.2941
0.0089 0.2929 0.2929
0.0164 0.4559 0.4559
0.004 0.3126 0.3126
0.014 0.2924 0.2805
0.0041 0.5218 0.1703
0.0045 0.5246 0.2306
0.0104 0.302 0.302
0.0058 0.2927 0.2927
0.0121 0.4307 0.4307
0.0094 0.3413 0.3413

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier EmuJ_000422300 (Echinococcus multilocularis), hemicentin 1
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