Detailed view for Sjp_0039610

Basic information

TDR Targets ID: 966222
Schistosoma japonicum, Alpha-1A adrenergic receptor, putative

Source Database / ID:  Wormbase Parasite  

pI: 9.2739 | Length (AA): 348 | MW (Da): 40004 | Paralog Number: 7

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 6

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00001   7 transmembrane receptor (rhodopsin family)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0004930   G-protein coupled receptor activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 347 2ziy (A) 5 338 19.00 0 0.17 1.0767 0.57
40 341 3pbl (A) 34 398 40.00 0 0.92 0.864617 0.34
120 149 1hll (A) 2 31 47.00 0 0.02 0.300155 2.49
297 328 5x33 (A) 253 286 22.00 0 0.01 -0.083081 3.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_150630)

Species Accession Gene Product
Schistosoma japonicum Sjp_0039600   Octopamine receptor, putative
Schistosoma japonicum Sjp_0107180   5-hydroxytryptamine receptor 4, putative
Schistosoma japonicum Sjp_0310780   Octopamine receptor, putative
Schistosoma japonicum Sjp_0206980   ko:K04145 dopamine receptor D2, putative
Schistosoma japonicum Sjp_0039610   Alpha-1A adrenergic receptor, putative
Schistosoma japonicum Sjp_0039580   Octopamine receptor 1, putative
Schistosoma japonicum Sjp_0039590   ko:K04145 dopamine receptor D2, putative
Schistosoma japonicum Sjp_0100900   Probable G-protein coupled receptor No18, putative
Schistosoma mansoni Smp_043270   biogenic amine receptor
Schistosoma mansoni Smp_043330   histamine h1 receptor
Schistosoma mansoni Smp_043260   histamine-responsive GPCR (AAF21638)
Schistosoma mansoni Smp_043340   biogenic amine (dopamine) receptor
Schistosoma mansoni Smp_043320   biogenic amine receptor
Schistosoma mansoni Smp_043300   biogenic amine (dopamine) receptor
Schistosoma mansoni Smp_043290   biogenic amine receptor
Schistosoma mansoni Smp_145520   adenoreceptor

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Gallus gallus Melatonin receptor 346 aa 22.8% 325 aa Compounds References
Bos taurus Adenosine receptor A3 317 aa 24.8% 323 aa Compounds References
Macaca mulatta Trace amine-associated receptor 1 338 aa 27.2% 342 aa Compounds References
Macaca fascicularis Melanin-concentrating hormone receptor 1 249 aa 22.8% 285 aa Compounds References
Rattus norvegicus Adenosine receptor 332 aa 21.7% 332 aa Compounds References
Sus scrofa Serotonin 1d (5-HT1d) receptor 291 aa 32.4% 296 aa Compounds References
Rattus norvegicus Melanocortin receptor 4 332 aa 24.2% 322 aa Compounds References
Rattus norvegicus Galanin receptor 1 346 aa 22.2% 325 aa Compounds References
Rattus norvegicus Bradykinin B1 receptor 337 aa 21.5% 382 aa Compounds References
Rattus norvegicus Adenosine A3 receptor 320 aa 24.9% 325 aa Compounds References
Gallus gallus Melatonin receptor 1B 289 aa 18.2% 302 aa Compounds References
Macaca fascicularis G-protein coupled receptor 119 335 aa 24.4% 312 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 1 332 aa 28.0% 321 aa Compounds References
Rattus norvegicus Gonadotropin-releasing hormone receptor 327 aa 19.7% 290 aa Compounds References
Rattus norvegicus Adenosine A1 receptor 326 aa 28.1% 295 aa Compounds References
Oryctolagus cuniculus Adenosine A3 receptor 319 aa 22.5% 306 aa Compounds References
Gallus gallus Adenosine A1 receptor 324 aa 27.5% 306 aa Compounds References
Canis lupus familiaris Uncharacterized protein 335 aa 24.2% 289 aa Compounds References
Rattus norvegicus Melanocortin receptor 3 323 aa 25.4% 335 aa Compounds References
Sus scrofa Serotonin 1b (5-HT1b) receptor 150 aa 28.7% 150 aa Compounds References
Rattus norvegicus Adenosine A2b receptor 332 aa 21.7% 332 aa Compounds References
Cavia porcellus Mu opioid receptor 98 aa 34.7% 98 aa Compounds References
Canis lupus familiaris Adenosine receptor A3 314 aa 23.8% 315 aa Compounds References

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0039610 (Schistosoma japonicum), Alpha-1A adrenergic receptor, putative
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