Detailed view for Sjp_0046610

Basic information

TDR Targets ID: 966426
Schistosoma japonicum, ko:K02353 dishevelled, putative
Source Database / ID:  Wormbase Parasite  

pI: 6.5501 | Length (AA): 1065 | MW (Da): 115133 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00595   PDZ domain (Also known as DHR or GLGF)
PF00610   Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PF00778   DIX domain
PF02377   Dishevelled specific domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0016055   Wnt receptor signaling pathway  
GO:0005515   protein binding  

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 80 4wip (A) 11 91 70.00 0 1 0.904826 -0.67
3 81 3pz8 (A) 3 84 75.00 0 1 0.906912 -0.4
222 330 3cc0 (A) 262 367 65.00 0 1 0.888334 -1.34
256 299 1kwa (A) 515 558 36.00 0.46 0.87 0.504919 -0.43
416 531 3ml6 (B) 422 1195 58.00 0 1 0.668733 -0.28
731 763 3bog (C) 3 67 99.99 0 0 1.02986 -0.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130104)

Species Accession Gene Product
Brugia malayi Bm1_23120   Domain found in Dishevelled, Egl-10, and Pleckstrin family protein
Caenorhabditis elegans CELE_C34F11.9   Protein DSH-1, isoform C
Drosophila melanogaster Dmel_CG18361   dishevelled
Echinococcus granulosus EgrG_000118000   segment polarity protein dishevelled
Echinococcus granulosus EgrG_000423700   segment polarity protein dishevelled
Echinococcus multilocularis EmuJ_000118000   segment polarity protein dishevelled
Echinococcus multilocularis EmuJ_000423700   segment polarity protein dishevelled
Homo sapiens ENSG00000004975   dishevelled segment polarity protein 2
Homo sapiens ENSG00000107404   dishevelled segment polarity protein 1
Homo sapiens ENSG00000161202   dishevelled segment polarity protein 3
Loa Loa (eye worm) LOAG_01675   hypothetical protein
Mus musculus ENSMUSG00000020888   dishevelled 2, dsh homolog (Drosophila)
Mus musculus ENSMUSG00000029071   dishevelled, dsh homolog 1 (Drosophila)
Mus musculus ENSMUSG00000003233   dishevelled 3, dsh homolog (Drosophila)
Onchocerca volvulus OVOC10923   Segment polarity protein dishevelled homolog
Schistosoma japonicum Sjp_0046610   ko:K02353 dishevelled, putative
Schistosoma japonicum Sjp_0059100   Segment polarity protein dishevelled homolog DVL-1, putative
Schistosoma japonicum Sjp_0119220   Segment polarity protein dishevelled homolog DVL-1, putative
Schistosoma japonicum Sjp_0128000   expressed protein
Schistosoma mansoni Smp_162410   dishevelled
Schistosoma mansoni Smp_020300   dishevelled
Schmidtea mediterranea mk4.003249.00   Dixin
Schmidtea mediterranea mk4.003249.01   Dvl-2

Essentiality

Sjp_0046610 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C34F11.9 Caenorhabditis elegans embryonic lethal wormbase
CELE_C34F11.9 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens dishevelled segment polarity protein 1 Compounds References
Homo sapiens dishevelled segment polarity protein 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Sjp_0046610 (Schistosoma japonicum), ko:K02353 dishevelled, putative
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